Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration
Open accessAbstract
Ubiquinone is an endogenous quinone with pharmacological actions mainly related to its antioxidant properties. Here we report that ubiquinone protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. In control cultures at 9 days of maturation in vitro (DIV), a 30-min exposure to 100 μ M glutamate induced neuronal degeneration, as reflected by the great percentage (>90%) of cells labeled with propidium iodide 24 h after the exposure. Glutamate-induced neuronal death was dramatically reduced in cultures treated daily with ubiquinone since the second DIV. In these cultures, glutamate failed to induce a “delayed” increase in the influx of 45 Ca 2+ , an established parameter of excitotoxicity. Similarly, repeated addition of ubiquinone attenuated in a concentration-dependent manner the age-dependent degeneration of granule cells that is due to the toxic action of the endogenous glutamate progressively released into the medium. These results suggest that ubiquinone may be a useful drug in the therapy of acute and chronic neurodegenerative diseases related to hyperactivity of excitatory amino acid neurotransmission.
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References 31 · Cited by 98
Research works printed but not linked: 2
- J Cereb Blood Flow Metab, Vol. 12, No.4, 1992
- Packer L, Kagan V, Serbinova E (1991) Participation of ubiqui nones in membrane antioxidation: Direct radical scavenging or tocopherol recycling. In: Biomedical and Clinical Aspects of Coenzyme Q, Vol. 6 (Folkers K, Littarro GP, Yamagami T, eds), Amsterdam, Elsevier Science Publishers, pp 115- 123
- Authors
- Favit, A., Nicoletti, F., Scapagnini, U., & Canonico, P. L.
- Affiliations
- University of Catania (IT)
- University of Pavia (IT)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1992-07
- Volume
- 12
- Issue
- 4
- Pages
- 638-645
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2019431280
- Cited by
- 98
- References
- 31
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- coenzyme Q10, neuroprotection, excitotoxicity, glutamate excitotoxicity, cerebellar granule cells, neurodegeneration, calcium influx, age-dependent degeneration, excitatory amino acid neurotransmission, neurodegenerative diseases, antioxidants
- MeSH terms
- Animals, Calcium, Cells, Cultured, Cerebellum, Glutamates, Nervous System Diseases, Neurons, Neurotoxins, Ubiquinone, Receptors, N-Methyl-D-Aspartate, Cell Death, Glutamic Acid, Rats
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