Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
Open accessAbstract
Obesity and vitamin D deficiency have both been linked to augmented activity of the tissue renin-angiotensin system (RAS). We investigated whether obesity status influenced the relationship between 25-hydroxyvitamin D (25(OH)D) and vascular RAS activity. The levels of 25(OH)D were measured in hypertensive obese (n=39) and non-obese (n=58) Caucasian individuals. RAS activity was assessed by plasma renin activity, and evaluation of the vascular sensitivity to angiotensin II (AngII) using the mean arterial pressure (MAP) response to an infusion of AngII. Among obese subjects, 25(OH)D was an independent positive predictor of the MAP response to AngII (β=0.70, r=0.41, P<0.01); lower 25(OH)D concentrations were associated with a blunted MAP response to AngII. In contrast, 25(OH)D did not significantly predict the vascular sensitivity to AngII in non-obese subjects (β=0.10, r=0.07, P=0.62). A multivariable-adjusted interaction model confirmed that the positive relationship between 25(OH)D and the vascular sensitivity to AngII strengthened with obesity (P-interaction=0.03). These findings demonstrate a positive association between 25(OH)D and the vascular sensitivity to AngII in obese hypertensives, and further suggest that vascular RAS activity may progressively increase when 25(OH)D deficiency occurs in obesity. Future studies to evaluate the effect of vitamin D supplementation on vascular RAS activity in obesity are needed.
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Vitamin D deficiency blunts tissue-responsiveness to exogenous angiotensin II by inducing a state of high tissue-RAAS activity.
“We previously showed that vitamin D deficiency blunts tissue-responsiveness to exogenous AngII by inducing a state of high tissue-RAAS activity4,6,31; this blunted sensitivity to AngII could be corrected by lowering the tissue-RAAS with an ACE inhibitor or vitamin D3 therapy4,33.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [6]
When integrated with Study 1, an incremental relationship between the RAAS and PTH was observed, modulated by angiotensin II dose, ACE inhibition, and vitamin D status.
“When integrated with the findings from Study 1 (Figure 1a–c), an incremental relationship between the RAAS and PTH was observed, which was modulated by AngII dose, as well as by ACE inhibition and vitamin D status (both of which sensitize the tissue responsiveness to AngII infusion)4,6,31–33.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [6]
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References 50 · Cited by 52
- Authors
- Vaidya, A., Forman, J. P., & Williams, J. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Vaidya, A
- Venue
- Journal of Human Hypertension
- Published
- 2010-12-02
- Volume
- 25
- Issue
- 11
- Pages
- 672-678
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- PMC
- PMC3146961
- OpenAlex
- W2064281552
- Cited by
- 52
- References
- 50
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 5
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Human Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1k23hl004236-01)
- National Heart, Lung, and Blood Institute (K23HL084236, F32HL104776, Z01HL004236, K23 HL04236-03, K08HL079929)
- National Center for Research Resources (M01 RR 02635, UL1RR025758, M01RR002635)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- vitamin D, 25-hydroxyvitamin D, obesity, hypertension, angiotensin II, vascular sensitivity, renin-angiotensin system, plasma renin activity, vitamin D deficiency, Caucasian adults
- MeSH terms
- Angiotensin II, Blood Pressure, Female, France, Humans, Hypertension, Infusions, Parenteral, Male, Middle Aged, Obesity, Renin, Renin-Angiotensin System, Retrospective Studies, Risk Factors, United States, Vitamin D, Vitamin D Deficiency, Biomarkers, Chi-Square Distribution, Risk Assessment, White People
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