Dermal Nitrite Application Enhances Global Nitric Oxide Availability: New Therapeutic Potential for Immunomodulation?
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Dermal nitrite administration potently inhibits Th2-derived cytokine IL-13 levels in bronchial alveolar lavage fluid.
“dermal nitrite administration potently inhibited Th2-derived cytokine, IL-13 levels, in bronchial alveolar lavage fluid.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [247]
Topical administration of 10 mg/kg−1 nitrite markedly increases nitrite, nitrate, RXNO, and NO-heme species in most tissue compartments sparing the kidney [nitrite], brain [nitrate, RXNO, NO-heme], and plasma [RXNO, NO-heme].
“This study reported that topical administration of 10 mg/kg−1 nitrite, markedly increased nitrite, nitrate, RXNO, and NO-heme species in most tissue compartments sparing the kidney [nitrite], brain [nitrate, RXNO, NO-heme], and plasma [RXNO, NO-heme], where no change of the bracketed NO metabolites occurred.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [247]
A 45-60% drop in T cells occurs shortly after dermal nitrite application.
“It was observed that a 45–60% drop in T cells occurred shortly after dermal nitrite application.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [247]
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References 33 · Cited by 8
- Authors
- Garcia-Saura, M. F., Fernandez, B. O., McAllister, B. P., Whitlock, D. R., Cruikshank, W. W., & Feelisch, M.
- Affiliations
- Boston University (US)
- Massachusetts Historical Society (US)
- Corresponding author
- Feelisch, Martin
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 130
- Issue
- 2
- Pages
- 608-611
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2003178167
- Cited by
- 8
- References
- 33
- Citations by year
- 2018: 1 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- National Institutes of Health
- Medical Research Council
- National Heart, Lung, and Blood Institute (HL-07224, T32HL007224, HL-69029, R01HL069029)
- National Institute on Drug Abuse (DA020644, R21DA020644)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- nitric oxide bioavailability, N-nitroso compounds, immunomodulation, topical drug delivery, skin blood flow, wound healing, antimicrobial activity, nitric oxide synthase inhibition, nitric oxide donors
- MeSH terms
- Animals, Asthma, Humans, Hydrogen-Ion Concentration, Mice, Transgenic, Models, Biological, Nitric Oxide, Nitrites, Risk, Skin, Mice, Immunomodulation
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