The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis
Open accessAbstract
Macrophages are important cells of the innate immune system, and their study is essential to gain greater understanding of the inflammatory nature of psoriasis. We used immunohistochemistry and double-label immunofluorescence to characterize CD163+ macrophages in psoriasis. Dermal macrophages were increased in psoriasis compared to normal skin and were identified by CD163, RFD7, CD68, LAMP2, Stabilin-1, and MARCO. CD163+ macrophages expressed C-lectins CD206/MMR and CD209/DC-SIGN, as well as co-stimulatory molecules CD86 and CD40. They did not express mature DC markers CD208/DC-LAMP, CD205/DEC205 or CD83. Microarray analysis of in vitro derived macrophages treated with IFNγ showed that many of the genes upregulated in macrophages were found in psoriasis, including STAT1, CXCL9, Mx1 and HLA-DR. CD163+ macrophages produced inflammatory molecules IL-23p19 and IL-12/23p40 as well as TNF and iNOS. These data demonstrate that CD163 is a superior marker of macrophages, and identifies a subpopulation of “classically activated” macrophages in psoriasis. We conclude that macrophages are likely to be contributing to the pathogenic inflammation in psoriasis, a prototypical Th1 and Th17 disease, by releasing key inflammatory products.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Cited by
Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,650
Self-citationThe role of macrophage phenotype in vascularization of tissue engineering scaffolds
Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin
Esaki, H., Brunner, P. M., Renert-Yuval, Y., Czarnowicki, T., Huynh, T., Tran, G., Lyon, S., Rodriguez, G., Immaneni, S., Johnson, D. B., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.013 · Cited by 428
Self-citationThe Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
Inflammatory dendritic cells in mice and humans
Segura, E., & Amigorena, S. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.06.001 · Cited by 300
Metadata
- Authors
- Fuentes-Duculan, J., Suárez-Fariñas, M., Zaba, L. C., Nograles, K. E., Pierson, K. C., Mitsui, H., Pensabene, C. A., Kzhyshkowska, J., Krueger, J. G., & Lowes, M. A.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 130
- Issue
- 10
- Pages
- 2412-2422
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1991658642
- Cited by
- 282
- References
- 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fuentes-Duculan, J., Suárez-Fariñas, M., Zaba, L. C., Nograles, K. E., Pierson, K. C., Mitsui, H., Pensabene, C. A., Kzhyshkowska, J., Krueger, J. G., & Lowes, M. A. (2010). A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis. Journal of Investigative Dermatology. https://doi.org/10.1038/jid.2010.165
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
