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Cited by 160Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesSpondyloarthritis Studies and Treatments

Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques

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Johnson-Huang, Leanne M., Suárez-Fariñas, Mayte, Sullivan-Whalen, Mary, Gilleaudeau, Patricia, Krueger, James G., Lowes, Michelle A.·2010·Journal of Investigative Dermatology
DOI 10.1038/jid.2010.166PMC PMC2955161
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Abstract

Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n=8) or nonresponsive (n=6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in nonresponsive plaques. NB-UVB decreased the numbers of CD11c(+) DCs, specifically CD1c(-)CD11c(+) "inflammatory" DCs, and their products, IL-20, inducible nitric oxide synthase, IL-12/23p40, and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNAs, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://www.nature.com/jid/journalclub.

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  • In T cells, UVB can eliminate the mRNA of IL-12 and decrease interferon-gamma producing T-cells by over 50%.

    “In T cells, UVB can eliminate the mRNA of IL-12 and decrease interferon-gamma (IFN-) producing T-cells by over 50% [71,72].”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [72]

    The Results section (‘IL-17 and IL-22 were reduced in normalized plaques’; page unavailable) reports an average 85% decrease in IFN-γ after NB-UVB irradiation of PBMCs used as a surrogate source of T cells. The Results section (‘Decreased dendritic cell cytokines in normalized plaques’; page unavailable) reports reduced IL-12/23p40 mRNA in responsive skin plaques, not elimination of IL-12 mRNA in T cells. The paper also does not quantify a decrease in the number of IFN-γ-producing T cells. (LLM, conf=0.86)

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  1. Aufiero BM Talwar H Young C Krishnan M Hatfield JS Lee HK 2006 Narrow-band UVB induces apoptosis in human keratinocytes J Photochem Photobiol B 82 132 139 16309917
  2. Baadsgaard O Salvo B Mannie A Dass B Fox DA Cooper KD 1990 In vivo ultraviolet-exposed human epidermal cells activate T suppressor cell pathways that involve CD4+CD45RA+ suppressor-inducer T cells J Immunol 145 2854 2861 1976706
  3. Bard JD Gelebart P Anand M Amin HM Lai R 2008 Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma Leukemia 22 1595 1603 18509351 PMC3429118
  4. Berg D Otley CC 2002 Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management J Am Acad Dermatol 47 1 17 quiz 18–20 12077575
  5. Blauvelt A 2008 T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis J Invest Dermatol 128 1064 1067 18408745 PMC2885349
  6. Boniface K Bernard FX Garcia M Gurney AL Lecron JC Morel F 2005 IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes J Immunol 174 3695 3702 15749908
  7. Bruls WA Slaper H van der Leun JC Berrens L 1984 Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths Photochem Photobiol 40 485 494 6505037
  8. Carrascosa JM Tapia G Bielsa I Fuente MJ Ferrandiz C 2007 Effects of narrowband UV-B on pharmacodynamic markers of response to therapy: an immunohistochemical study over sequential samples J Cutan Pathol 34 769 776 17880582
  9. Chamian F Lowes MA Lin SL Lee E Kikuchi T Gilleaudeau P 2005 Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris Proc Natl Acad Sci U S A 102 2075 2080 15671179 PMC545584
  10. Di Cesare A Di Meglio P Nestle FO 2009 The IL-23/Th17 axis in the immunopathogenesis of psoriasis J Invest Dermatol 129 1339 1350 19322214
  11. Erkin G Ugur Y Gurer CK Asan E Korkusuz P Sahin S 2007 Effect of PUVA, narrow-band UVB and cyclosporin on inflammatory cells of the psoriatic plaque J Cutan Pathol 34 213 219 17302604
  12. Goettsch W Hurks HM Garssen J Mommaas AM Slob W Hoekman J 1998 Comparative immunotoxicology of ultraviolet B exposure I. Effects of in vitro and in situ ultraviolet B exposure on the functional activity and morphology of Langerhans cells in the skin of different species Br J Dermatol 139 230 238 9767236
  13. Guttman-Yassky E Lowes MA Fuentes-Duculan J Zaba LC Cardinale I Nograles KE 2008 Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis J Immunol 181 7420 7427 18981165 PMC3470474
  14. Haider AS Lowes MA Suarez-Farinas M Zaba LC Cardinale I Khatcherian A 2008 Identification of Cellular Pathways of “Type 1,” Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis J Immunol 180 1913 1920 18209089
  15. Harper EG Guo C Rizzo H Lillis JV Kurtz SE Skorcheva I 2009 Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis J Invest Dermatol PMC2892172 19295614
  16. Hearn RM Kerr AC Rahim KF Ferguson J Dawe RS 2008 Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy Br J Dermatol 159 931 935 18834483
  17. Krueger JG Wolfe JT Nabeya RT Vallat VP Gilleaudeau P Heftler NS 1995 Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells J Exp Med 182 2057 2068 7500051 PMC2192269
  18. Lebwohl M 2003 Psoriasis Lancet 361 1197 1204 12686053
  19. Lowes M Chamian F Abello MV Fuentes-Duculan J Lin SL Nussbaum R 2005a Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) Proc Natl Acad Sci USA 102 19057 19062 16380428 PMC1323218
  20. Lowes MA Kikuchi T Fuentes-Duculan J Cardinale I Zaba LC Haider AS 2008 Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells J Invest Dermatol 128 1207 1211 18200064
  21. Lowes MA Turton JA Krueger JG Barnetson RS 2005b Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series BMC Dermatol 5 9 16109173 PMC1208875
  22. Maeda A Schneider SW Kojima M Beissert S Schwarz T Schwarz A 2006 Enhanced photocarcinogenesis in interleukin-12-deficient mice Cancer Res 66 2962 2969 16540644
  23. Mahmoud BH Hexsel CL Hamzavi IH Lim HW 2008 Effects of visible light on the skin Photochem Photobiol 84 450 462 18248499
  24. Murphy GM Norris PG Young AR Corbett MF Hawk JL 1993 Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells Br J Dermatol 129 674 677 7506927
  25. Nestle FO Kaplan DH Barker J 2009 Psoriasis N Engl J Med 361 496 509 19641206
  26. Nograles KE Zaba LC Guttman-Yassky E Fuentes-Duculan J Suarez-Farinas M Cardinale I 2008 Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways Br J Dermatol 159 1086 1091 18684158 PMC2724264
  27. Noonan FP De Fabo EC Morrison H 1988 Cis-urocanic acid, a product formed by ultraviolet B irradiation of the skin, initiates an antigen presentation defect in splenic dendritic cells in vivo J Invest Dermatol 90 92 99 2448393
  28. Ozawa M Ferenczi K Kikuchi T Cardinale I Austin LM Coven TR 1999 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions J Exp Med 189 711 718 9989986 PMC2192929
  29. Patel RV Clark LN Lebwohl M Weinberg JM 2009 Treatments for psoriasis and the risk of malignancy J Am Acad Dermatol 60 1001 1017 19344980
  30. Pene J Chevalier S Preisser L Venereau E Guilleux MH Ghannam S 2008 Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes J Immunol 180 7423 7430 18490742
  31. Piskin G Koomen CW Picavet D Bos JD Teunissen MB 2003 Ultraviolet-B irradiation decreases IFN-gamma and increases IL-4 expression in psoriatic lesional skin in situ and in cultured dermal T cells derived from these lesions Exp Dermatol 12 172 180 12702146
  32. Piskin G Sylva-Steenland RM Bos JD Teunissen MB 2004a T cells in psoriatic lesional skin that survive conventional therapy with NB-UVB radiation display reduced IFN-gamma expression Arch Dermatol Res 295 509 516 15024577
  33. Piskin G Tursen U Sylva-Steenland RM Bos JD Teunissen MB 2004b Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23 Exp Dermatol 13 764 772 15560760
  34. Sa SM Valdez PA Wu J Jung K Zhong F Hall L 2007 The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis J Immunol 178 2229 2240 17277128
  35. Sigmundsdottir H Johnston A Gudjonsson JE Valdimarsson H 2005 Narrowband-UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells Arch Dermatol Res 297 39 42 15889264
  36. Simon JC Tigelaar RE Bergstresser PR Edelbaum D Cruz PD Jr 1991 Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells J Immunol 146 485 491 1670944
  37. Tjioe M Smits T van de Kerkhof PC Gerritsen MJ 2003 The differential effect of broad band vs narrow band UVB with respect to photodamage and cutaneous inflammation Exp Dermatol 12 729 733 14714551
  38. Walters IB Burack LH Coven TR Gilleaudeau P Krueger JG 1999 Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris J Am Acad Dermatol 40 893 900 10365919
  39. Walters IB Ozawa M Cardinale I Gilleaudeau P Trepicchio WL Bliss J 2003 Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level Arch Dermatol 139 155 161 12588221
  40. Weischer M Blum A Eberhard F Rocken M Berneburg M 2004 No evidence for increased skin cancer risk in psoriasis patients treated with broadband or narrowband UVB phototherapy: a first retrospective study Acta Derm Venereol 84 370 374 15370703
  41. Wittkowski KM Lee E Nussbaum R Chamian FN Krueger JG 2004 Combining several ordinal measures in clinical studies Stat Med 23 1579 1592 15122738
  42. Yones SS Palmer RA Garibaldinos TT Hawk JL 2006 Randomized double-blind trial of the treatment of chronic plaque psoriasis: efficacy of psoralen-UV-A therapy vs narrowband UV-B therapy Arch Dermatol 142 836 842 16847198
  43. Zaba L Cardinale I Gilleaudeau P Sullivan-Whalen M Suárez-Fariñas M Fuentes-Duculan J 2007a Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses J Exp Med 204 3183 3194 18039949 PMC2150965
  44. Zaba LC Fuentes-Duculan J Eungdamrong NJ Abello MV Novitskaya I Pierson KC 2009a Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells J Invest Dermatol 129 79 88 18633443 PMC2701224
  45. Zaba LC Fuentes-Duculan J Steinman RM Krueger JG Lowes MA 2007b Normal human dermis contains distinct populations of CD11cBDCA-1 dendritic cells and CD163FXIIIA macrophages J Clin Invest 117 2517 2525 17786242 PMC1957542
  46. Zaba LC Krueger JG Lowes MA 2009b Resident and “inflammatory” dendritic cells in human skin J Invest Dermatol 129 302 308 18685620 PMC2746703
  47. Zhang W Chen Y Wei H Zheng C Sun R Zhang J 2008 Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts Clin Cancer Res 14 6432 6439 18927282

Cited by

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Authors
Johnson-Huang, L. M., Suárez-Fariñas, M., Sullivan-Whalen, M., Gilleaudeau, P., Krueger, J. G., & Lowes, M. A.
Affiliations
Rockefeller University (US)
Corresponding author
Lowes, Michelle A.
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2010-11
Volume
130
Issue
11
Pages
2654-2663
ISSN
0022-202X (ISSN-L)
DOI
10.1038/jid.2010.166
PMC
PMC2955161
OpenAlex
W1999459135
Cited by
160
References
0
Citations by year
2026: 5 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 6 · 2016: 18 · 2015: 10 · 2014: 14 · 2013: 17 · 2012: 12
FWCI
6.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (P50HL054469)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23AR052404)
  • National Center for Research Resources (UL1RR024143)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Keywords
psoriasis, IL-23/IL-17 axis, IL-17, IL-22, IL-20, IL-12/23p40, IL-23p19, myeloid dendritic cells, CD11c+ dendritic cells, inducible nitric oxide synthase, T cells, psoriatic inflammation, treatment response
MeSH terms
Adult, Biopsy, Dendritic Cells, Humans, Interferon-gamma, Psoriasis, Skin, T-Lymphocytes, Ultraviolet Therapy, Gene Expression, Interleukin-17, Interleukin-23

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