Vitamin D analogs 17, 20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity
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Short side chain secosteroids and their 5,7-diene precursors have anti-fibrotic activities, defined by inhibition of TGF-β1-induced collagen protein production and hyaluronan synthesis, with similar potency to 1,25(OH)2D3.
“Secosteroids with a short side chain and their corresponding 5,7-diene precursors, had anti-fibrotic activities as defined by inhibition of TGF-β1 induced collagen protein production and hyaluronan synthesis, with a similar potency to 1,25(OH)2D3.”
From The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions (2014) · cites this paper as [85]
17,20S(OH)2pD and 17,20R(OH)2pD are non-calcemic in mice up to the highest dose tested of 3 μg/kg.
“we tested 17,20S(OH)2pD and 17,20R(OH)2pD in mice and have found that they are non-calcemic up to the highest dose tested of 3 μg/kg [85].”
From The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions (2014) · cites this paper as [85]
Pharmacologically administered 20(OH)D3 has antifibrotic activity in vitro and in vivo in bleomycin-induced scleroderma.
“Pharmacologically administered 20(OH) D3 shows antifibrotic activities both in vitro [57,117,118] and in vivo in bleomycin induced scleroderma [118].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [117]
In vitro studies with exogenously added compounds show that novel CYP11A1-derived secosteroids and Δ7-steroids have anti-proliferative, pro-differentiation, and anti-inflammatory effects on cultured skin cells, depending on the compound's structure and the cell lineage.
“Importantly, in vitro studies with exogenously added compounds reveal that novel CYP11A1-derived secosteroids and Δ7steroids exerts anti-proliferative, pro-differentiation, and anti-inflammatory effects on cultured skin cells, which are dependent on the structure of the compound and the cell lineage [57,104,112,114–119].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [117]
They show in vitro anti-proliferative effects against melanoma cells, melanocytes, keratinocytes and fibroblasts and anti-fibrotic activities.
“they show in vitro anti-proliferative effects against melanoma cells, melanocytes, keratinocytes and fibroblasts as well as anti-fibrotic activities [189, 191, 192, 194, 196, 197]”
From The serum vitamin D metabolome: what we know and what is still to discover (2019) · cites this paper as [196]
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References 14 · Cited by 51
- Authors
- Slominski, A. T., Li, W., Bhattacharya, S. K., Smith, R. A., Johnson, P. L., Chen, J., Nelson, K. E., Tuckey, R. C., Miller, D., Jiao, Y., Gu, W., & Postlethwaite, A. E.
- Affiliations
- University of Tennessee Health Science Center (US)
- Christian Brothers University (US)
- The University of Western Australia (AU)
- Corresponding author
- Slominski, Andrzej T.
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 131
- Issue
- 5
- Pages
- 1167-1169
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC3078214
- OpenAlex
- W2048531918
- Cited by
- 51
- References
- 14
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 8 · 2012: 6
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion, other-oa)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01A052190)
- U.S. Department of Veterans Affairs
- National Institutes of Health
- American Electric Power
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- vitamin D analogs, 7-dehydrocholesterol, steroidogenic pathway, antifibrotic activity, systemic sclerosis
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Calcium, Cells, Cultured, Cholecalciferol, Female, Fibroblast Growth Factors, Fibroblasts, Fibrosis, Humans, Mice, Inbred C57BL, Phosphates, Vitamin D, Bone Density, Dermis, Mice
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