Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans
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Items 101–183 of 183
- Long‐term safety and efficacy of the sodium–glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon‐like peptide‐1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52‐week open‐label, multicenter, post‐marketing clinical studyYasuo Terauchi, Hisataka Fujiwara, Yuji Kurihara, Hideki Suganami, Masahiro Tamura, Masayuki Senda, Ryoji Gunji, Kohei Kaku · 2019 · Journal of Diabetes Investigation
- Empagliflozin for the treatment of type 2 diabetes mellitus: An overview of safety and efficacy based on P hase 3 trials 艾格列净治疗2型糖尿病:基于3期试验的安全性与有效性概述GEORGE E. DAILEY · 2015 · Journal of Diabetes
- In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidneyToshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito et al. · 2024 · Molecular Therapy — Nucleic Acids
- Sodium-glucose cotransporter (SGLT) 2 inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk for development of type 2 diabetes mellitusBianca Hemmingsen, Jesper Krogh, Maria‐Inti Metzendorf, Bernd Richter · 2016 · Cochrane Database of Systematic Reviews
- Sodium-glucose cotransporter 2 inhibitors as the first universal treatment of chronic kidney diseaseUsama A. Sharaf El Din, Mona Mansour Salem, Dina Ossama Abdulazim · 2021 · Nefrología
- Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume RetentionToshimi Imai, Tetsu Akimoto, Chiharu Ito, Takahiro Masuda, Daisuke Nagata · 2015 · Drug Target Insights
- Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic ratsLijuan Wang, Liji Huang, Nan Li, Junjun Miao, Wei Liu, Jiangyi Yu · 2019 · Cellular and Molecular Biology
- Anti-Obesity Pharmacotherapy and the Potential for Preventing Progression from Prediabetes to Type 2 DiabetesAlan J. Garber · 2015 · Endocrine Practice
- Adverse Liver and Renal Outcomes After Initiating SGLT ‐2i and GLP ‐ 1RA Therapy Among Patients With Diabetes and MASLDArunkumar Krishnan, Carolin Victoria Schneider, Diptasree Mukherjee, Tinsay A. Woreta, Saleh A. Alqahtani · 2025 · Journal of Diabetes
- Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus: Results of 24‐month interim analysis of a long‐term post‐marketing study (J‐STEP/LT)Kazunori Utsunomiya, Seigo Kakiuchi, Masayuki Senda, Shoko Fujii, Yuji Kurihara, Ryoji Gunji, Ryusuke Koshida, Hiroyuki Kameda, Masahiro Tamura, Kohei Kaku · 2020 · Journal of Diabetes Investigation
- Emerging horizons: clinical applications and multifaceted benefits of SGLT-2 inhibitors beyond diabetesQing Feng, Moya Wu, Zizhao Mai · 2025 · Frontiers in Cardiovascular Medicine
- Repurposing metabolic drugs as anti-inflammatory agentsAndrew E. Hogan, Cian Davis, Benjamin Jenkins, Nicholas Jones, Donal Brendan O'Shea · 2025 · Trends in Endocrinology and Metabolism
- Targeting Neurodegeneration with SGLT2is: From Molecular Mechanisms to Clinical ImplicationsHamideh Asadinejad, Soroush Taherkhani, Sakine Mosaei Golboos, Yaser Azizi, Ali Mohammadkhanizadeh · 2025 · Molecular Neurobiology
- Japanese study of tofogliflozin with type 2 diabetes mellitus patients in an observational study of the elderly (J‐ STEP / EL ): A 12‐week interim analysisKazunori Utsunomiya, Naoki Shimmoto, Masayuki Senda, Yuji Kurihara, Ryoji Gunji, Hiroyuki Kameda, Masahiro Tamura, Hanako Mihara, Kohei Kaku · 2016 · Journal of Diabetes Investigation
- Sodium–glucose cotransporter 2 inhibitors in horses—Magic bullet or latest fad?Tania Sundra, Guy D. Lester, Gabriele Rossi, David I. Rendle · 2023 · Equine Veterinary Journal
- Circulating complement‐1q tumor necrosis factor‐α‐related protein isoform 5 levels are low in type 2 diabetes patients and reduced by dapagliflozinCheng Zhang, Yong Luo, Rui Liu, Xiaoqiang Li, Mengliu Yang, Yu Zhang, Ling Li, Huaming Mou, Lian Guo, Jing Li et al. · 2019 · Journal of Diabetes Investigation
- Toxicology of Medications for Diabetes MellitusKevin T. Baumgartner, Jason M. Devgun · 2021 · Critical Care Clinics
- Retrospective review of SGLT2 inhibitor exposures reported to 13 poison centersScott E. Schaeffer, Carol DesLauriers, Henry A. Spiller, Alfred Aleguas, Salvador Baeza, Mark L. Ryan · 2017 · Clinical Toxicology
- A practical approach to hyperinsulinaemia in horses with equine metabolic syndromeTania Sundra, Gabriele Rossi, David I. Rendle, Guy D. Lester · 2024 · Equine Veterinary Education
- Sodium-glucose cotransporter 2 inhibitors and cardiorenal outcomes in kidney transplantationGauranga Mahalwar, Roy O. Mathew, Janani Rangaswami · 2023 · Current Opinion in Nephrology & Hypertension
- Horse owner experiences and observations with the use of SGLT2i for the management of equine metabolic syndrome and hyperinsulinaemia‐associated laminitisTania Sundra, Erin A. Kelty, Gabriele Rossi, Guy D. Lester, David I. Rendle · 2024 · Equine Veterinary Education
- New avenues for the pharmacological management of type 2 diabetes: An updateThomas Cuny, Bruno Guerci, Bertrand Cariou · 2012 · Annales d Endocrinologie
- Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metforminChing-Lun Chien, Yen‐Chou Chen, Daniel C. Malone, Yueh-Lung Peng, Yu Ko · 2020 · Current Medical Research and Opinion
- Safety of sodium–glucose c otransporter 2 inhibitors in Asian type 2 diabetes populationsJaime A. Davidson, Norlela Sukor, Fen‐Lee Hew, Mafauzy Mohamed, Zanariah Binti Hussein · 2022 · Journal of Diabetes Investigation
- Pharmacological Treatments for Type 2 DiabetesRoberto Pontarolo, Andréia Cristina Conegero Sanches, Astrid Wiens, Cássio Marques Perlin, Fernanda S. Tonin, Helena Hiemisch Lobo Borba, Luana Lenzi, Suelem Tavares da Silva Penteado · 2015 · InTech eBooks
- A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitisMelody Anne de Laat, Martin N. Sillence · 2020 · Animal Production Science
- Comparison betweeen dapagliflozin add-on therapy and insulin dose escalation in patients with uncontrolled type 2 diabetes treated with insulin: DVI studyYujin Shin, Haeri Choi, Soo Kyung Lim · 2021 · Diabetes Research and Clinical Practice
- Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozinJonathan A. Phillips, Mitchell E. Taub, Matthew S. Bogdanffy, Jing Yuan, Brian Knight, James D. Smith, Warren W. Ku · 2022 · Journal of Applied Toxicology
- Sodium-glucose cotransporter 2 inhibitors as the first universal treatment of chronic kidney diseaseUsama A. Sharaf El Din, Mona Mansour Salem, Dina Ossama Abdulazim · 2022 · Nefrología (English Edition)
- Do sodium‐glucose co‐transporter‐2 inhibitors increase plasma glucagon by direct actions on the alpha cell? And does the increase matter for the associated increase in endogenous glucose production?Rune E. Kuhre, Carolyn Fiona Deacon, Nicolai J. Wewer Albrechtsen, Jens Juul Holst · 2021 · Diabetes Obesity and Metabolism
- Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 DiabetesShivani Sharma, Amit Mittal, Shubham Kumar, Anu Mittal · 2021 · Current Diabetes Reviews
- Design, Syntheses, and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium‐Dependent Glucose Cotransporter 2 InhibitorsTony K. M. Shing, Wai‐Lung Ng, Judy Yuet‐Wa Chan, Clara Bik‐San Lau · 2013 · Angewandte Chemie
- The Association between Urinary Glucose and Renal Uric Acid Excretion in Non-diabetic Patients with Stage 1-2 Chronic Kidney DiseaseXinhui Feng, Yuqi Zheng, Haochen Guan, Xun Clare Zhou, Ying Xu, Xiaoli Zhang, Chensheng Fu, Jing Xiao, Zhibin Ye · 2020 · Endocrine Research
- Glucosuric, renal and haemodynamic effects of licogliflozin, a dual inhibitor of sodium‐glucose co‐transporter‐1 and sodium‐glucose co‐transporter‐2, in patients with chronic kidney disease: A randomized trialYanling He, Alok S. Pachori, Ping Chen, Shenglin Ma, Anisha E. Mendonza, Ahmed Amer, Thomas C Marbury, Markus Hinder · 2021 · Diabetes Obesity and Metabolism
- SGLT2 inhibitors and AMPK crosstalk in diabetes mellitus: mechanistic insights and therapeutic applicationsKiavash Hushmandi, Navvabeh Salarizadeh, Behzad Einollahi, Morteza Izadi, Pardis Doosti, Mohammad Javad Behzadnia, William C. Cho, Tooba Yousefi, Seyedeh Mahdieh Khoshnazar, Mina Alimohammadi et al. · 2026 · Journal of Diabetes & Metabolic Disorders
- Intensifying Treatment Beyond Monotherapy in Type 2 Diabetes Mellitus: Where Do Newer Therapies Fit?Alexander Kühn, Jean Park, Adline Ghazi, Vanita R. Aroda · 2017 · Current Cardiology Reports
- Knowledge domain and emerging trends in empagliflozin for heart failure: A bibliometric and visualized analysisXuesong Zhang, Ying Zhang, Yuanhui Hu · 2022 · Frontiers in Cardiovascular Medicine
- Design, Synthesis and in vivo Evaluation of Novel C‐Aryl Glucosides as Potent Sodium‐Dependent Glucose Cotransporters Inhibitors for the Treatment of DiabetesZheng Li, Xuekun Wang, Xue Jun Xu, Qianqian Qiu, Lei Jiao, Wenlong Huang, Hai Qian · 2015 · Chemical Biology & Drug Design
- A novel SGLT2 inhibitor, SU-011, improves glycaemic control in rodents without the risk of hypoglycaemia and weight gainFei Huang, Fuwei Dai, Jianhua Bi, Lanxiang Hao, Chunlei Wang, Ke Xu, Yanmei Liu, Xingbo Cheng · 2019 · Journal of Pharmacy and Pharmacology
- Sodium-glucose cotransporter (SGLT) 2 inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk for development of type 2 diabetes mellitusBianca Hemmingsen, Jesper Krogh, Maria‐Inti Metzendorf, Bernd Richter · 2016 · Cochrane Database of Systematic Reviews
- Effects of SGLT2 inhibition on insulin use in CKD and type 2 diabetes: insights from the CREDENCE trialBryony Beal, Luke Buizen, Emily K. Yeung, Lauren Heath, Lauren Houston, David Z.I. Cherney, Meg Jardine, Carol A. Pollock, Clare Gabrielle Arnott, Sradha S. Kotwal et al. · 2025 · Nephrology Dialysis Transplantation
- Plant-derived Natural Products in Neurological and Psychiatric Disorders: Mechanisms of Action and Synergistic Roles with ProbioticsMustafa M Shokr, Abdelghafar Mohamed Abu-Elsaoud, Seham M. Al Raish · 2026 · Molecular Neurobiology
- Study Design and Protocol for a Randomized Controlled Trial of Enavogliflozin to Evaluate Cardiorenal Outcomes in Type 2 Diabetes (ENVELOP)Nam Hoon Kim, Soo Kyung Lim, In‐Kyung Jeong, Eun‐Jung Rhee, Jun Sung Moon, Ohk‐Hyun Ryu, Hyuk‐Sang Kwon, Jong Chul Won, Sang Soo Kim, Sang Yong Kim et al. · 2025 · Diabetes & Metabolism Journal
- Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelinesOscar L. Morey‐Vargas, Mona Gossmann, Jeffrey M. Ketz, Basem Abdelmalak · 2025 · Cleveland Clinic Journal of Medicine
- Comparison of the efficacy and safety of 10-mg empagliflozin every day versus every other day in Japanese patients with Type 2 Diabetes Mellitus: a pilot trialFumiaki Obata, Kenji Tani, Harutaka Yamaguchi, Ryo Tabata, Hiroyasu Bando, Issei Imoto · 2017 · The Journal of Medical Investigation
- Sodium-Glucose Cotransporter-2 Inhibitors: Risks vs. Rewards When Caring for Older AdultsErica Wilson, Aminah Jones, Nicole Brandt · 2022 · Journal of Gerontological Nursing
- A Comparison of the Efficacy of Dapagliflozin Metformin Versus Sitagliptin Metformin: in Newly Diagnosed Type 2 DiabetesAfra Ishtiaque, Shahreen Mehmood Khan, Salman Azhar, Mehreen Mehmood, Saira Shahnawaz · 2022
- In Vitro Cytotoxic, Genotoxic, Embryotoxic and Oxidative Damage Potentials by EmpagliflozinKenan Çadırcı, Hasan Türkez, Özlem Özdemir Tozlu, Ömer Erkan Yapça, Muharrem Bayrak, Buğrahan Emsen, Adil Mardinoğlu · 2024 · Biology Bulletin
- Pharmacokinetics and Safety of Fixed‐Dose Versus Separate Enavogliflozin/Gemigliptin Combinations, and Food Effect on Enavogliflozin in Healthy Korean SubjectsYoung‐Sim Choi, JaeJin Na, Seo Yeong Park, Jae Min Cho, Yoonhye Jeong, Jun Gi Hwang · 2025 · Clinical and Translational Science
- Identification of New Small-Molecule SGLT2 Inhibitors: In-Silico Approach to Therapeutics for Diabetes-Related ComplicationsAshanul Haque, Khalaf M. Alenezi, Md. Jahoor Alam, Safia Tazyeen · 2025 · ACS Omega
- Exploring the Therapeutic Potential of Sodium–Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis in Patients with Type 2 Diabetes: A Narrative ReviewSulthan Al Rashid, Arun Suriyan, Mohamed Bilal Azam, Rajkapoor Balasubramanian, Naina Mohamed Pakkir Maideen, Kumarappan Chidambaram, Palanisamy Amirthalingam · 2026 · Hormone and Metabolic Research
- Effects of sodium-glucose cotransporter 2 inhibitors on body weight and metabolic parameters in obese patients with and without type 2 diabetes: a systematized narrative reviewDjordje Baletic, Nataša Božić, M. Paut Kusturica, Ljiljana Tomić, Violeta Ilić Todorović, Sara Vasović, Aleksandar Rašković · 2026 · Current Medical Research and Opinion
- Nutritional and Metabolic Management of the Diabetic Patient with Chronic Kidney Disease and Chronic Renal FailureMark E. Williams, Robert C. Stanton · 2012 · Elsevier eBooks
- Inhibitory kotransportera glukozowo- -sodowego 2 (SGLT2): nowa grupa doustnych leków przeciwcukrzycowychBlazej Przybyslawski, Piotr Karbowiak, Jacek Rzeszotarski, L Walasek · 2013 · Via Medica Journals
- An Emerging Protagonist: Sodium Glucose Co-transporters (SGLTs) as a Burgeoning Target for the Treatment of Diabetes MellitusDanish Ahmed, Manju Sharma, Vikas Kumar, Pankaj S Yadav · 2012 · Journal of Diabetes & Metabolism
- The Effects of Sodium-Glucose Co-Transporter-2 Inhibitors (SGLT-2-i) on Fatty Liver, Steato-Hepatitis, Liver Fibrosis, and Hepatocellular Carcinoma-A ReviewHyder Osman Mirghani, Thomas Antony Thaniyath, Fakhralddin Abbas Elfakki · 2019 · Biology and Medicine
- The Impact of SGLT2i Therapy on the Onset and Prognosis of Heart Failure in Patients with Type 2 DiabetesBogdan Timar, Adina Braha, Lucica Grigorică, Laura Gaiţă, Romulus Zorin Timar · 2020 · Timişoara Medical Journal
- Pharmacological Treatments for Type 2 DiabetesRoberto Pontarolo, Andria Cristina Conegero Sanches, Astrid Wiens, Helena Hiemisch Lobo Borba, Luana Lenzi, Suelem Tavares da Silva Penteado · 2013 · InTech eBooks
- Dapagliflozin as add-on to Metformin; Network Meta-Analysis and Budget Impact AnalysisEdoardo Mannucci, Enrico Torre, Patrizia Berto · 2015 · Global & Regional Health Technology Assessment
- Kidneys function in glucose homeostasis regulation and its therapeutic implicationsEwa Otto-Buczkowska, Krzysztof Tucholski · 2013 · Family Medicine & Primary Care Review
- SGLT2 inhibitors: New medicines for addressing unmet therapeutic needs in type 2 diabetesRobert Geoffrey Moses, Stephen Colagiuri, Carol A. Pollock · 2014 · Australasian Medical Journal
- Long-term mono- or dual-combination empagliflozin treatment for adults with type 2 diabetes mellitusBernd Richter, Elizabeth Bandeira-Echtler, Maria‐Inti Metzendorf, Bianca Hemmingsen · 2018 · Cochrane Database of Systematic Reviews
- Clinical Considerations When Introducing Sodium-Glucose Co-Transporter 2 Inhibition in Patients With Heart FailureMayu Yazaki, Takeru Nabeta, Takayuki Inomata, Kenji Maemura, Takumi Ooki, Teppei Fujita, Yuichiro Iida, Yuki Ikeda, Shunsuke Ishii, Takashi Naruke et al. · 2019 · Circulation Reports
- A translational viewpoint explaining its potential salutary effectsAnne E. de Leeuw, Rudolf A. de Boer · 2016 · European Heart Journal - Cardiovascular Pharmacotherapy
- Hormonal Actions and Interactions in Proximal Tubule Cells Associated with the Development of Chronic Kidney DiseaseAkihiko Saito, Michihiro Hosojima, Hiroyoshi Sato · 2011 · InTech eBooks
- Use of a sodium–glucose cotransporter 2 inhibitor in a patient with chronic kidney diseaseMichelle Lam, Adrian Coleman · 2016 · Journal of Renal Nursing
- Empaglifozin and the reduction of risk of death in a high cardiovascular risk populationÍtalo Cordeiro Moreira, Gabriel Pereira Bernardo, D'ávila Suyane Belém de Lima, Cecília Brenda Rocha Carneiro, Débora Laésia Saraiva Ribeiro, Mariana Carleial Feijó de Sá, Maria Jaionara de Macedo, Priscila Passos Campelo Moreira, Vanessa Lacerda Araújo, José Nunes de Alencar et al. · 2016 · International Archives of Medicine
- ORAL HYPOGLYCAEMIC AGENTS IN THE MANAGEMENT OF TYPE II DIABETES MELLITUSDurgaprasad Mallappa Kabade, Anand Koppad, Ameet Vasanthrao Khatawkar, Savitri Durgaprasad Kabade, Afaq Ahmed · 2016 · Journal of Evidence Based Medicine and Healthcare
- What Next After Metformin? Guidelines and Indian ContextChandalia Hb · 2017 · Current Research in Diabetes & Obesity Journal
- Equine Insulin Dysregulation and Laminitis: Developing a Framework for Testing Treatment and Preventive StrategiesAlexandra Meier · 2019 · Queensland University of Technology
- Discordance between fasting plasma glucose and A1c in the diagnosis and management of diabetesVeerasak Sarinnapakorn, Chaicharn Deerochanawong, Sathit Niramitmahapanya, Navaporn Napartivaumnuay, Thitinan Treesaranuwattana · 2021 · World Journal of Advanced Research and Reviews
- Nutritional and metabolic management of the diabetic patient with chronic kidney disease and chronic renal failureMark E. Williams, Robert C. Stanton · 2021 · Elsevier eBooks
- Reno Protective Effect of Sodium Glucose Cotransporter-2 Inhibitor (Dapagliflozin) in Type 2 Diabetic PatientsRasha O. Abdelmoniem, Marwa S. Shaalan, M. Shawky, Walla M. lbrahim, Ayman Elbadawy · 2022 · The Egyptian Journal of Hospital Medicine
- Time to completely eradicate diabetic nephropathyUsama A. Sharaf El Din, Mona Mansour Salem, Dina Ossama Abdulazim · 2023 · Diabetic Nephropathy
- Estudo do efeito cardioprotetor da Empagliflozina no infarto agudo do miocárdio em ratos Wistar com diabetes induzida por estreptozotocinaBruno Durante da Silva · 2023
- Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in RatsYuqing Zhao, Yali Yuan, Shu Yan, Chongzhuang Tang, Yong Gan, Shiyan Guo, Xingxing Diao · 2025 · Biomedical Chromatography
- Cardiorenometabolic medicine as a new subspecialty in the light of novel pharmaceuticals with dual or triple benefitsSanja Medenica, Vladimir Prelević, Nikola Zanković, Viviana Maggio, Manfredi Rizzo · 2026 · Expert Opinion on Drug Safety
- Cardiovascular protection by SGLT2 inhibitors: an integrative review of mechanistic networks, clinical evidence, and safety considerationsZi Wang, Yijin Wang, Wangning Shangguan, Tao Li · 2026 · Frontiers in Cardiovascular Medicine
- Canagliflozin treatment of a horse with hyperinsulinemia, including pharmacokinetic analysis of different dosing protocols: a case reportCecily Burbidge, Katelyn White, Kate Armstrong, Brielle V. Rosa · 2026 · Frontiers in Veterinary Science
- Plantago ovata (Psyllium Husk) Ameliorates Streptozotocin-Induced Diabetes in Rats via Modulating Oxidative Stress and the Expression of PPAR-γ, Nrf2, and TNF-αSachin T Jose · 2026
- A Thorough Analysis of Analytical Techniques for Determining Dapagliflozin and Teneligliptin Hydrobromide Hydrate in Single and Combination Dosage FormsKalyani Sanjaykumar Patil, Javesh K. Patil, J. K. Patil · 2026 · Asian Journal of Pharmaceutical Research
- BindingDB Entry 50040597: Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.BindingDB · 2013 · UC San Diego
- Cardiac Electrophysiological Impact of Sodium Glucose Cotransporter 2 Inhibitors: A Comprehensive ReviewVishnu Ashok, Ven Gee Lim, S.M. Zubair Rahim, Hardip Sandhu, Michael S. Dodd, G. André Ng, Derek W. Renshaw, Helen L. Maddock, Faizel Osman · 2026 · Circulation Arrhythmia and Electrophysiology