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Identification of a urine metabolomic signature in patients with advanced-stage chronic kidney disease
Open accessAbstract
The prevalence of chronic kidney disease (CKD) is increasing and frequently progresses to end-stage renal disease. There is an urgent demand to discover novel markers of disease that allow monitoring disease progression and, eventually, response to treatment. To identify such markers, and as a proof of principle, we determined if a metabolite signature corresponding to CKD can be found in urine. In the discovery stage, we analyzed the urine metabolome by NMR of 15 patients with CKD and compared that with the metabolome of 15 healthy individuals and found a classification pattern clearly indicative of CKD. A validation cohort of urine samples from an additional 16 patients with CKD and 15 controls was then analyzed by (Selected Reaction Monitoring) liquid chromatography-triple quadrupole mass spectrometry and indicated that a group of seven urinary metabolites differed between CKD and non-CKD urine samples. This profile consisted of 5-oxoproline, glutamate, guanidoacetate, α-phenylacetylglutamine, taurine, citrate, and trimethylamine N-oxide. Thus, we identified a panel of urine metabolites differentially present in urine that may help identify and monitor patients with CKD.
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“Metabolomic analysis of urine from 31 patients identified a group of seven metabolites that differed between chronic kidney disease (CKD) and non-CKD urine samples; TMAO concentrations in plasma were higher in CKD (92).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [92]
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Metadata
- Authors
- Posada-Ayala, M., Zubiri, I., Martin-Lorenzo, M., Sanz-Maroto, A., Molero, D., Gonzalez-Calero, L., Fernandez-Fernandez, B., de la Cuesta, F., Laborde, C. M., Barderas, M. G., Ortiz, A., Vivanco, F., & Alvarez-Llamas, G.
- Affiliations
- Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ES)
- Universidad Complutense de Madrid (ES)
- Servicio de Salud de Castilla La Mancha (ES)
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 85
- Issue
- 1
- Pages
- 103-111
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2053835433
- Cited by
- 167
- References
- 22
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 13 · 2022: 14 · 2021: 11 · 2020: 24 · 2019: 15 · 2018: 14 · 2017: 15 · 2016: 16 · 2015: 10 · 2014: 10
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Hispana (submittedVersion)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chronic kidney disease, urine metabolomics, metabolomic signatures, biomarkers, disease progression monitoring, pyroglutamic acid, glutamate, taurine, citrate, trimethylamine N-oxide, NMR metabolomics, multiple reaction monitoring
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Kidney Failure, Chronic, Male, Middle Aged, Mass Spectrometry, Cohort Studies, Biomarkers, Case-Control Studies, Metabolome
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