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Cited by 43Smoking Behavior and CessationChronic Kidney Disease and DiabetesChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Smoking increases the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease

Open access
Nakamura, Koshi, Nakagawa, Hideaki, Murakami, Yoshitaka, Kitamura, Akihiko, Kiyama, Masahiko, Sakata, Kiyomi, Tsuji, Ichiro, Miura, Katsuyuki, Ueshima, Hirotsugu, Okamura, Tomonori·2015·Kidney International
DOI 10.1038/ki.2015.212
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Abstract

Little is known about the magnitude and nature of the combined effect of chronic kidney disease (CKD) and smoking on cardiovascular diseases. We studied this in a Japanese population using a pooled analysis of 15,468 men and 19,154 women aged 40-89 years enrolled in 8 cohort studies. The risk of mortality from all-causes and cardiovascular disease was compared in 6 gender-specific categories of baseline CKD status (non-CKD or CKD) and smoking habits (lifelong never smoked, former smokers, or currently smoking). CKD was defined as a decreased level of estimated glomerular filtration rate (under 60 ml/min per 1.73 m(2)) and/or dipstick proteinuria. Hazard ratios were estimated for each category, relative to never smokers without CKD. During the follow-up period (mean 14.8 years), there were 6771 deaths, 1975 of which were due to cardiovascular diseases. In both men and women, current or former smokers with CKD had the first or second highest crude mortality rates from all-cause and cardiovascular diseases among the 6 categories. After adjustment for age and other major cardiovascular risk factors, the hazard ratios in male and female current smokers with CKD were 2.26 (95% confidence interval, 1.95-2.63) and 1.78 (1.36-2.32) for all-causes, and 2.66 (2.04-3.47) and 1.71 (1.10-2.67) for cardiovascular diseases, respectively. Thus, coexistence of CKD and smoking may markedly increase the risk of all-cause and cardiovascular mortality.

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  • A prospective cohort study comparing the cardiovascular risk of current or former smokers versus never smokers in diabetic patients with CKD reported a higher incidence of cardiovascular events among current or prior smokers.

    “A prospective cohort study comparing the cardiovascular risk of current or former smokers versus never smokers in diabetic patients with CKD reported a higher incidence of cardiovascular events among current or prior smokers.”

    From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [187]

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Metadata

Authors
Nakamura, K., Nakagawa, H., Murakami, Y., Kitamura, A., Kiyama, M., Sakata, K., Tsuji, I., Miura, K., Ueshima, H., & Okamura, T.
Affiliations
  • Kanazawa Medical University (JP)
  • Toho University (JP)
  • The University of Osaka (JP)
  • Osaka Center for Cancer and Cardiovascular Disease Prevention (JP)
  • Iwate Medical University (JP)
  • Tohoku University (JP)
  • Shiga University of Medical Science (JP)
  • Keio University (JP)
Corresponding author
Nakamura, Koshi
ORCID
Venue
Kidney International
Publisher
Elsevier BV
Published
2015-11
Volume
88
Issue
5
Pages
1144-1152
ISSN
0085-2538 (ISSN-L)
DOI
10.1038/ki.2015.212
OpenAlex
W1906273428
Cited by
43
References
1
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 1
FWCI
3.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
chronic kidney disease, smoking, cardiovascular mortality, all-cause mortality, cardiovascular disease, estimated glomerular filtration rate, proteinuria, former smokers, current smokers, sex differences, pooled cohort analysis
MeSH terms
Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Cause of Death, Female, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Smoking, Comorbidity, Prevalence, Renal Insufficiency, Chronic

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