Side effects of pain and analgesia in animal experimentation
Open accessAbstract
This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory rodents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Specific pain management procedures can introduce variability, affecting experimental data.
“Untreated pain can affect the animals’ biology and add variability to the experiment; however, specific pain management procedures can also introduce variability, affecting experimental data [212,213].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [212]
Untreated pain can affect the animals' biology and add variability to the experiment.
“Untreated pain can affect the animals’ biology and add variability to the experiment; however, specific pain management procedures can also introduce variability, affecting experimental data [212,213].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [212]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802 · see citing works
Carbone, L., & Austin, J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155001 · Cited by 191 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Arras,M.,Rettich,A.,Cinelli,P.,Kasermann,H.P.&Burki,K.Assessment ofpost-laparotomypaininlaboratorymicebytelemetricrecordingof heartrateandheartratevariability.BMC Vet. Res.3,16(2007).
- Jirkof,P.et al.Burrowingbehaviorasanindicatorofpost-laparotomy paininmice.Front. Behav. Neurosci.4,165(2010).
- Mogil,J.S.Thegeneticmediationofindividualdifferencesinsensitivityto painanditsinhibition.Proc. Natl. Acad. Sci. USA96,7744-7751(1999).
- Rivat,C.&Ballantyne,J.Thedarksideofopioidsinpainmanagement: basicscienceexplainsclinicalobservation.PAIN Rep.1,e570(2016).
- Bimonte,S.et al.Morphinepromotestumorangiogenesisandincreases breastcancerprogression.Biomed Res. Int.2015,161508(2015).
- vanderSchier,R.,Roozekrans,M.,vanvelzen,M.,Dahan,A.&Niesters, M.Opioid-inducedrespiratorydepression:reversalbynon-opioiddrugs. F1000Prime Rep.6,79(2014).
Cited by
Sorted by citations
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000411 · Cited by 2,677 · see citing works
- Authors
- Jirkof, P.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Jirkof, Paulin
- ORCID
- Jirkof, Paulin
- Venue
- Lab Animal
- Published
- 2017-04
- Volume
- 46
- Issue
- 4
- Pages
- 123-128
- ISSN
- 0093-7355 (ISSN-L)
- 1548-4475
- OpenAlex
- W2600795801
- Cited by
- 124
- References
- 2
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 11 · 2023: 25 · 2022: 23 · 2021: 11 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Lab Animal (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- analgesia, opioids, nonsteroidal anti-inflammatory drugs, antipyretics, laboratory rodents, animal welfare
- MeSH terms
- Analgesia, Analgesics, Analgesics, Opioid, Animals, Anti-Inflammatory Agents, Non-Steroidal, Pain, Rodentia, Antipyretics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
