The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Contribution of bone microenvironment to leukemogenesis and leukemia progression
Open accessAbstract
Tumor microenvironment has a major role in cancer progression and resistance to treatment. The bone marrow (BM) is a dynamic network of growth factors, cytokines and stromal cells, providing a permissive environment for leukemogenesis and progression. Both BM stroma and leukemic blasts promote angiogenesis, which is increased in acute lymphoblastic leukemia and acute myeloid leukemia. Growth factors like vascular endothelial growth factor (VEGF), basic fibroblast growth factor and angiopoietins are the main proangiogenic mediators in acute leukemia. Autocrine proleukemic loops have been described for VEGF and angiopoietin in hematopoietic cells. Interactions of stromal cells and extracellular matrix with leukemic blasts can also generate antiapoptotic signals that contribute to neoplastic progression and persistence of treatment-resistant minimal residual disease. High expression of CXC chemokine ligand 4 (CXCR4) by leukemic blasts and activation of the CXCR4–CXCL12 axis is involved in leukemia progression and disruption of normal hematopoiesis. Leukemia-associated bone microenvironment markers could be used as prognostic or predictive indicators of disease progression and/or treatment outcome. Studies related to bone microenvironment would likely provide a better understanding of the treatment resistance associated with leukemia therapy and design of new treatments.
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Cites
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CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
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RNA Trafficking by Acute Myelogenous Leukemia Exosomes
Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A. M., Goloviznina, N. A., Roberts, C. T., & Kurre, P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2184 · Cited by 259
Bruce, A., Evans, R., Mezan, R., Shi, L., Moses, B. S., Martin, K. H., Gibson, L. F., & Yang, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140506 · Cited by 112
Abraham, M., Klein, S., Bulvik, B., Wald, H., Weiss, I. D., Olam, D., Weiss, L., Beider, K., Eizenberg, O., Wald, O., et al. (2017) · Leukemia · doi:10.1038/leu.2017.82 · Cited by 104
Metadata
- Authors
- Ayala, F., Dewar, R., Kieran, M., & Kalluri, R.
- Venue
- Leukemia
- Published
- 2009-09-03
- Volume
- 23
- Issue
- 12
- Pages
- 2233-2241
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W1980952112
- Cited by
- 273
- References
- 82
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
