The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation
Tarighat, S S, Santhanam, R, Frankhouser, D, Radomska, H S, Lai, H, Anghelina, M, Wang, H, Huang, X, Alinari, L, Walker, A, Caligiuri, M A, Croce, C M, Li, L, Garzon, R, Li, C, Baiocchi, R A, Marcucci, G·2016·Leukemia
Cited by (171)
Items 101–171 of 171
- TAF1 inhibitor Bay-299 induces cell death in acute myeloid leukemiaLixin Zhou, Qi Yao, Le Ma, Hui Li, Jieping Chen · 2021 · Translational Cancer Research
- PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphomaFiona Brown-Burke, Inah Hwang, Shelby L. Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Wing Keung Chan, Alexander Prouty, Ji-Hyun Chung, Yang Zhang et al. · 2023 · Blood Advances
- Cell metabolic profiling of colorectal cancer via 1H NMRSuyin Ge, Qingqing Zhang, Yizhen Tian, Luyang Hao, Jingru Duan, Baolai Zhang · 2020 · Clinica Chimica Acta
- circFAM193B interaction with PRMT6 regulates AML leukemia stem cells chemoresistance through altering the oxidative metabolism and lipid peroxidationXinyu Yang, Jinting Liu, Wancheng Liu, Hanyang Wu, Yihong Wei, Xiaodong Guo, Hexiao Jia, Can Can, Dongmei Wang, Xiang Hu et al. · 2024 · Leukemia
- FLT3 overexpression in acute leukaemias: New insights into the search for molecular mechanismsCaroline P. Poubel, Marcela Braga Mansur, Mariana Boroni, Mariana Emerenciano · 2019 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Therapeutic targeting of chromatin alterations in leukemia and solid tumorsFlorian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna M. Thomas, Michael W.M. Kühn, Michael Lübbert · 2025 · International Journal of Cancer
- An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesisJustin Ching Ting Loke, Peter Geon Kim, Thuy T. P. Nguyen, Meaghan Boileau, Marie E. McConkey, Aidan Miller, Wesley Shin, Christopher A. Hergott, Maria Ericsson, Anja E. H. Nordstrom et al. · 2025 · Blood
- The evolving landscape of epigenetic target molecules and therapies in myeloid cancers: focus on acute myeloid leukemia and myeloproliferative neoplasmsMichael W.M. Kühn, Naveen Pemmaraju, Florian Heinrich Heidel · 2025 · Leukemia
- Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for TherapyMichael Maher, Jeannine Diesch, Marguerite-Marie Le Pannérer, Marcus Buschbeck · 2021 · Cancers
- PRMTs and miRNAs: functional cooperation in cancer and beyondJiamin Jin, Matthew Martin, Antja-Voy Hartley, Tao Lu · 2019 · Cell Cycle
- Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabineLi‐Juan Tang, Guokang Sun, Ting‐juan Zhang, Dehong Wu, Jing‐dong Zhou, Bei-bei Ma, Zi‐jun Xu, Xiang-mei Wen, Qin Chen, Dong‐ming Yao et al. · 2019 · Cancer Cell International
- In silico approach of novel HPPD/PDS dual target inhibitors by pharmacophore, AILDE and molecular dockingJuan Shi, Hai‐Feng Cao, Chao‐Fan Wang, Shuang Gao, Jia-Yu Wang, Lixia Zhao, Fei Ye, Ying Fu · 2023 · Journal of the Taiwan Institute of Chemical Engineers
- SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progressionZhenyu Zhou, Zheng Chen, Qianlei Zhou, Shiyu Meng, Juanyi Shi, Sintim Mui, Hai Jiang, Jianhong Lin, Gui He, Wenbin Li et al. · 2024 · Cancer Science
- Targeting PRMT5 in cancer: Mechanistic insights and clinical progressJoohyun Lee, Jiye Kim, Inah Hwang · 2025 · Biomedicine & Pharmacotherapy
- Inflammation in cancer cachexia: still the central tenet or just another player?Noemi Iaia, Chiara Noviello, Maurizio Muscaritoli, Paola Costelli · 2025 · American Journal of Physiology-Cell Physiology
- Mechanisms of Histone ModificationsLudovica Vanzan, Athéna Sklias, Zdenko Herceg, Rabih Murr · 2017 · Elsevier eBooks
- Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemiasFrancesca Pirini, Anna Ferrari, Mouna Jandoubi, Irene Azzali, Davide Angeli, Rossana Mondrone, Chiara Bracci, Francesca Ruggieri, Giovanni Martinelli, Giorgia Simonetti · 2025 · Cell Death Discovery
- Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunitiesYoonae Jeong, Yena Cho, Yong Kee Kim · 2026 · Journal of Biomedical Science
- Research Progress on Small-molecule Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5) for Treating CancerChaohua Guo, Lintao Wu, Xumei Zheng, Lin Zhao, Xiaojia Hou, Zhijun Wang, Chun Han · 2023 · Current Topics in Medicinal Chemistry
- Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A reviewSaı̈d Sif, Majdi Al-Alawneh · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphomaShelby L. Sloan, Kyle A. Renaldo, Mackenzie Long, Ji-Hyun Chung, Lindsay E. Courtney, Konstantin Shilo, Youssef Youssef, Sarah Y. Schlotter, Fiona Brown-Burke, Brett G. Klamer et al. · 2021 · PLoS ONE
- PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARαXinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong‐Hu Zhu, Xiaofeng Zheng · 2022 · Cellular and Molecular Life Sciences
- The Role of Chromatin-Associated Proteins in CancerKristian Helin, Saverio Minucci · 2016 · Annual Review of Cancer Biology
- Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2low Adult T-Cell Leukemia/LymphomaTomonaga Ichikawa, Akira Suekane, Shingo Nakahata, Hidekatsu Iha, Kazuya Shimoda, Takashi Murakami, Kazuhiro Morishita · 2024 · International Journal of Molecular Sciences
- PRMT5: A Promising Synthetical Lethal Target for MTAP-Deleted CancersBang Li, Jin-Qi Yu, Zhenjiao Yang, Yuanxiang Wang · 2025 · Journal of Medicinal Chemistry
- The role of protein arginine methyltransferases in kidney diseasesChunyun Zhang, Shougang Zhuang · 2020 · Clinical Science
- Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML CellsYanni Sun, Yanni Ma, Xiaoqing Jia, Qi Yao, Jieping Chen, Hui Li · 2022 · Current Medical Science
- The role and application of transcriptional repressors in cancer treatmentMiso Park, Keon Wook Kang, Ji Won Kim · 2023 · Archives of Pharmacal Research
- Analysis of the error surface of the XOR network with two hidden nodesLen Hamey · 1996
- PRMT5-FOXM1 axis activates β-catenin/IL8 signaling to drive angiogenesis of gastric cancerXinyu Liu, Chenxiao Tu, Hongwei Yang, Bowen Tang, Yanwei Ye, Huanan Wang · 2025 · Cellular Signalling
- Excessive fatty acids activate PRMT5 / MDM2 /Drosha pathway to regulate miRNA biogenesis and lipid metabolismAijun Hou, Xiaoding Xu, Yu Zhang, Hongxiu He, Yihan Feng, Wenhui Fan, Rongrong Tan, Likun Gong, Jing Chen · 2024 · Liver International
- Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapyJohanna Rausch, Evelyn Ullrich, Michael W.M. Kühn · 2023 · Frontiers in Immunology
- A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathwayShuhong Dong, Ruiying Yang, Yingwen Wang, Xingqi Fang, Xiang Han, Meng Gu, Shi‐Wu Chen, Baolai Zhang · 2025 · Biochemical Pharmacology
- Targeting the epigenome and tumor heterogeneity: advances in immunotherapy for chemoresistant metastatic colorectal cancerYu J Cao, Narasimha Murthy Beeraka, Sergey K. Efetov, Zheng Liu, Akmalbek A. Otabekov, Basappa Basappa, Wensheng Wang, Dan Ma · 2025 · Frontiers in Immunology
- Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 InhibitorsTyler M. Brown, Mengtong Cao, Yujun George Zheng · 2022 · Molecules
- Dysregulated YY1/PRMT5 axis promotes the progression and metastasis of laryngeal cancer by targeting Hippo pathwayNan Wang, Di Wu, Long Qian, Yue Yan, Xiaoqi Chen, Zheng Zhao, Honghong Yan, Xinrui Zhang, Meilan Xu, Wuguo Deng et al. · 2020 · Journal of Cellular and Molecular Medicine
- Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluationsQian Zhang, Lun Zhang, Jia Jin, Yaohua Fan, Xiaoguang Wang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Chenxi Cao, Fei Ye · 2022 · Journal of Molecular Modeling
- Dysregulation of arginine methylation in tumorigenesisLi Xiao, Yaqiong Song, Weiwei Mu, Xiaoli Hou, Te Ba, Shaoping Ji · 2024 · Frontiers in Molecular Biosciences
- Purification and Identification of Natural Inhibitors of Protein Arginine Methyltransferases from PlantsZhengxin Wang, Ling Xiong, Quanbo Xiong · 2022 · Molecular and Cellular Biology
- The methylation induced by protein arginine methyltransferase 5 promotes tumorigenesis and progression of lung cancerPengyu Jing, Nianlin Xie, Ximing Zhu, Haizhou Dang, Zhongping Gu · 2018 · Journal of Thoracic Disease
- Alterations of histone modifications in cancerMaha Mohamed Saber-Ayad, Wafaa S.H. Ramadan, Raafat El‐Awady · 2023 · Elsevier eBooks
- Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparumHui Min, Amuza Byaruhanga Lucky, Jesper J. Madsen, Anongruk Chim-Ong, Xiaolian Li, Liwang Cui, Jun Miao · 2024 · Antimicrobial Agents and Chemotherapy
- Drug discovery targeting protein arginine methyltransferase 5 (PRMT5): an updateZhouyang Gu, Weijia Kong, Xing Liu, Lang Hu, Yucheng Zhou, Zhenchu Liang, Minyue Zhang, Dongyin Chen, Fei Li, Weilin Chen · 2025 · Bioorganic & Medicinal Chemistry
- Novel Drugs Targeting the EpigenomeZhuo Chen, Honglin Li · 2017 · Current Pharmacology Reports
- The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized MedicineQing Yan · 2022 · Methods in molecular biology
- PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback LoopFan Yang, Ping Song, Zhaofeng Xiao, Renyi Su, Xin Fang, Yichao Wu, Xiao Xu, Kai Wang · 2025 · MedComm
- Carcinogenesis and Prognostic Utility of Arginine Methylation-Related Genes in Hepatocellular CancerWaleed M Ali, Weirui Xiao, Henry Hoang, Vincent J. Cali, Andre Kajdacsy‐Balla · 2023 · Current Issues in Molecular Biology
- A synergistic interaction between PRMT5 and LSD1 inhibitors in AMLNesteene Joy Param, Elisa Arceci, Francesco Fiorentino, Luca Pignata, Denis Torre, Nayeli Gutiérrez, Jia Yi Fong, Pierre-Alexis Vincent Goy, Yuyuan Han, Chiara Lambona et al. · 2026 · Science Advances
- 13q12.2 deletions and FLT3 overexpression in acute leukemiasCaroline P. Poubel, Mariana Boroni, Mariana Emerenciano · 2021 · Blood Advances
- PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosisFiona Brown-Burke, Rachel Saadey, Hsiaoyin Charlene Mao, Paola Marra, Eric Brooks, Alexa Wandtke, Ian Hout, Sydney Leon, Archisha Sharma, Aneeq Yasin et al. · 2025 · Blood Advances
- Cotargeting of Androgen Synthesis and Androgen Receptor Expression as a Novel Treatment for Castration-Resistant Prostate CancerChang‐Deng Hu, Xuehong Deng, Elena Beketova, Jake L. Owens, Jonathan Malola · 2017
- PRMT InhibitorsMatthijs J. van Haren, Nathaniel I. Martin · 2019 · Topics in medicinal chemistry
- The Polymerase Associated Factor Complex-Protein Arginine Methyltransferase Axis: A Mechanism of Acute LeukemiaJustin Serio · 2017 · Deep Blue (University of Michigan)
- Characterizing the Role of Protein Arginine Methyltransferase 5 in Colon CancerJudy Truong · 2018 · TSpace (University of Toronto)
- Identification of PRMT5 Inhibitors with Novel Scaffold Structures through Virtual Screening and Biological EvaluationsLun Zhang, Chenxi Cao, Jia Jin, Yaohua Fan, Xiaoguang Wang, Qian Zhang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Fei Ye · 2021 · Research Square
- Faculty Opinions recommendation of PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes.Scott A. Ness · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Analysis and synthesis of cellular decision making: modeling epigenetic regulation in cell fate networks and designing a distributed synthetic counter circuitTianchi Chen · 2022 · Digital Repository Service (Northeastern University)
- Emerging epigenetic therapies: protein arginine methyltransferase inhibitorsHannah Pook, Siim Pauklin · 2023 · Elsevier eBooks
- PRMT5 inhibitors for lower-risk myelodysplasia: Is there anywhere to move?Andrej Terzic, David J. Curtis · 2023 · Leukemia Research
- RECENT ADVANCES IN TARGETING THE PRMT5/MTA COMPLEXChristopher R. Smith, Matthew A. Marx · 2023 · Medicinal chemistry reviews
- PRMT5 Inhibition Enhances Therapeutic Efficacy of Cisplatin via Mediating miR‐29b‐3p‐Mcl‐1 Expression in Lung AdenocarcinomaHaichao Li, Jiangjiang Fan, Weiwei Shen, Yong Zhang, Ximing Zhu, Pei Li, Zhongping Gu, Pengyu Jing · 2025 · Cell Biology International
- PRMT5:MEP50 Are Mediators of Treatment‐Induced Neuroendocrine Differentiation in Prostate CancerHye Seung Nam, Andrew Michael Asberry, Xuehong Deng, Sheng Liu, Jiaoti Huang, Chang‐Deng Hu, Jun Wan, Michael K. Wendt · 2025 · The Prostate
- The role of PRMT5-mediated methylation of steroid receptor in breast CancerThuy Ha Pham · 2022 · theses.fr (ABES)
- CARM1 disrupts interactions between ALIX and its partners through arginine methylation and promotes cytokinetic abscissionSolène Huard · 2024 · theses.fr (ABES)
- PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinomaHao Jiang, Jin-Hua Yan, Wen-Jing Tang, Bin Shen, Shuai Mo, Yang Wang, De-Hua Hu, Zhixiong Dong, Shu-Bing Zhang · 2026 · World Journal of Gastroenterology
- Epigenetic alterations in Myeloid MalignanciesBruno António Cardoso · 2026 · Advances in experimental medicine and biology
- Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancerMeigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng · 2026 · Molecular Oncology
- BindingDB Entry 50002756: Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50012961: A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50021155: Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50019870: Targeting Arginine Methyltransferase PRMT5 for Cancer Therapy: Updated Progress and Novel Strategies.BindingDB · 2024 · UC San Diego