The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

Cited by (171)

Items 101–171 of 171

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    Xinyu Yang, Jinting Liu, Wancheng Liu, Hanyang Wu, Yihong Wei, Xiaodong Guo, Hexiao Jia, Can Can, Dongmei Wang, Xiang Hu et al. · 2024 · Leukemia
  5. FLT3 overexpression in acute leukaemias: New insights into the search for molecular mechanisms
    Caroline P. Poubel, Marcela Braga Mansur, Mariana Boroni, Mariana Emerenciano · 2019 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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    Justin Ching Ting Loke, Peter Geon Kim, Thuy T. P. Nguyen, Meaghan Boileau, Marie E. McConkey, Aidan Miller, Wesley Shin, Christopher A. Hergott, Maria Ericsson, Anja E. H. Nordstrom et al. · 2025 · Blood
  8. The evolving landscape of epigenetic target molecules and therapies in myeloid cancers: focus on acute myeloid leukemia and myeloproliferative neoplasms
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  9. Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy
    Michael Maher, Jeannine Diesch, Marguerite-Marie Le Pannérer, Marcus Buschbeck · 2021 · Cancers
  10. PRMTs and miRNAs: functional cooperation in cancer and beyond
    Jiamin Jin, Matthew Martin, Antja-Voy Hartley, Tao Lu · 2019 · Cell Cycle
  11. Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine
    Li‐Juan Tang, Guokang Sun, Ting‐juan Zhang, Dehong Wu, Jing‐dong Zhou, Bei-bei Ma, Zi‐jun Xu, Xiang-mei Wen, Qin Chen, Dong‐ming Yao et al. · 2019 · Cancer Cell International
  12. In silico approach of novel HPPD/PDS dual target inhibitors by pharmacophore, AILDE and molecular docking
    Juan Shi, Hai‐Feng Cao, Chao‐Fan Wang, Shuang Gao, Jia-Yu Wang, Lixia Zhao, Fei Ye, Ying Fu · 2023 · Journal of the Taiwan Institute of Chemical Engineers
  13. SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression
    Zhenyu Zhou, Zheng Chen, Qianlei Zhou, Shiyu Meng, Juanyi Shi, Sintim Mui, Hai Jiang, Jianhong Lin, Gui He, Wenbin Li et al. · 2024 · Cancer Science
  14. Targeting PRMT5 in cancer: Mechanistic insights and clinical progress
    Joohyun Lee, Jiye Kim, Inah Hwang · 2025 · Biomedicine & Pharmacotherapy
  15. Inflammation in cancer cachexia: still the central tenet or just another player?
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  16. Mechanisms of Histone Modifications
    Ludovica Vanzan, Athéna Sklias, Zdenko Herceg, Rabih Murr · 2017 · Elsevier eBooks
  17. Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias
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  18. Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities
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  19. Research Progress on Small-molecule Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5) for Treating Cancer
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  20. Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review
    Saı̈d Sif, Majdi Al-Alawneh · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  21. Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma
    Shelby L. Sloan, Kyle A. Renaldo, Mackenzie Long, Ji-Hyun Chung, Lindsay E. Courtney, Konstantin Shilo, Youssef Youssef, Sarah Y. Schlotter, Fiona Brown-Burke, Brett G. Klamer et al. · 2021 · PLoS ONE
  22. PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα
    Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong‐Hu Zhu, Xiaofeng Zheng · 2022 · Cellular and Molecular Life Sciences
  23. The Role of Chromatin-Associated Proteins in Cancer
    Kristian Helin, Saverio Minucci · 2016 · Annual Review of Cancer Biology
  24. Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2low Adult T-Cell Leukemia/Lymphoma
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  25. PRMT5: A Promising Synthetical Lethal Target for MTAP-Deleted Cancers
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  26. The role of protein arginine methyltransferases in kidney diseases
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  29. Analysis of the error surface of the XOR network with two hidden nodes
    Len Hamey · 1996
  30. PRMT5-FOXM1 axis activates β-catenin/IL8 signaling to drive angiogenesis of gastric cancer
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  31. Excessive fatty acids activate PRMT5 / MDM2 /Drosha pathway to regulate miRNA biogenesis and lipid metabolism
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  32. Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy
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  33. A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathway
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  34. Targeting the epigenome and tumor heterogeneity: advances in immunotherapy for chemoresistant metastatic colorectal cancer
    Yu J Cao, Narasimha Murthy Beeraka, Sergey K. Efetov, Zheng Liu, Akmalbek A. Otabekov, Basappa Basappa, Wensheng Wang, Dan Ma · 2025 · Frontiers in Immunology
  35. Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors
    Tyler M. Brown, Mengtong Cao, Yujun George Zheng · 2022 · Molecules
  36. Dysregulated YY1/PRMT5 axis promotes the progression and metastasis of laryngeal cancer by targeting Hippo pathway
    Nan Wang, Di Wu, Long Qian, Yue Yan, Xiaoqi Chen, Zheng Zhao, Honghong Yan, Xinrui Zhang, Meilan Xu, Wuguo Deng et al. · 2020 · Journal of Cellular and Molecular Medicine
  37. Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations
    Qian Zhang, Lun Zhang, Jia Jin, Yaohua Fan, Xiaoguang Wang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Chenxi Cao, Fei Ye · 2022 · Journal of Molecular Modeling
  38. Dysregulation of arginine methylation in tumorigenesis
    Li Xiao, Yaqiong Song, Weiwei Mu, Xiaoli Hou, Te Ba, Shaoping Ji · 2024 · Frontiers in Molecular Biosciences
  39. Purification and Identification of Natural Inhibitors of Protein Arginine Methyltransferases from Plants
    Zhengxin Wang, Ling Xiong, Quanbo Xiong · 2022 · Molecular and Cellular Biology
  40. The methylation induced by protein arginine methyltransferase 5 promotes tumorigenesis and progression of lung cancer
    Pengyu Jing, Nianlin Xie, Ximing Zhu, Haizhou Dang, Zhongping Gu · 2018 · Journal of Thoracic Disease
  41. Alterations of histone modifications in cancer
    Maha Mohamed Saber-Ayad, Wafaa S.H. Ramadan, Raafat El‐Awady · 2023 · Elsevier eBooks
  42. Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to Plasmodium falciparum
    Hui Min, Amuza Byaruhanga Lucky, Jesper J. Madsen, Anongruk Chim-Ong, Xiaolian Li, Liwang Cui, Jun Miao · 2024 · Antimicrobial Agents and Chemotherapy
  43. Drug discovery targeting protein arginine methyltransferase 5 (PRMT5): an update
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  44. Novel Drugs Targeting the Epigenome
    Zhuo Chen, Honglin Li · 2017 · Current Pharmacology Reports
  45. The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine
    Qing Yan · 2022 · Methods in molecular biology
  46. PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop
    Fan Yang, Ping Song, Zhaofeng Xiao, Renyi Su, Xin Fang, Yichao Wu, Xiao Xu, Kai Wang · 2025 · MedComm
  47. Carcinogenesis and Prognostic Utility of Arginine Methylation-Related Genes in Hepatocellular Cancer
    Waleed M Ali, Weirui Xiao, Henry Hoang, Vincent J. Cali, Andre Kajdacsy‐Balla · 2023 · Current Issues in Molecular Biology
  48. A synergistic interaction between PRMT5 and LSD1 inhibitors in AML
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  49. 13q12.2 deletions and FLT3 overexpression in acute leukemias
    Caroline P. Poubel, Mariana Boroni, Mariana Emerenciano · 2021 · Blood Advances
  50. PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis
    Fiona Brown-Burke, Rachel Saadey, Hsiaoyin Charlene Mao, Paola Marra, Eric Brooks, Alexa Wandtke, Ian Hout, Sydney Leon, Archisha Sharma, Aneeq Yasin et al. · 2025 · Blood Advances
  51. Cotargeting of Androgen Synthesis and Androgen Receptor Expression as a Novel Treatment for Castration-Resistant Prostate Cancer
    Chang‐Deng Hu, Xuehong Deng, Elena Beketova, Jake L. Owens, Jonathan Malola · 2017
  52. PRMT Inhibitors
    Matthijs J. van Haren, Nathaniel I. Martin · 2019 · Topics in medicinal chemistry
  53. The Polymerase Associated Factor Complex-Protein Arginine Methyltransferase Axis: A Mechanism of Acute Leukemia
    Justin Serio · 2017 · Deep Blue (University of Michigan)
  54. Characterizing the Role of Protein Arginine Methyltransferase 5 in Colon Cancer
    Judy Truong · 2018 · TSpace (University of Toronto)
  55. Identification of PRMT5 Inhibitors with Novel Scaffold Structures through Virtual Screening and Biological Evaluations
    Lun Zhang, Chenxi Cao, Jia Jin, Yaohua Fan, Xiaoguang Wang, Qian Zhang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Fei Ye · 2021 · Research Square
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  62. PRMT5:MEP50 Are Mediators of Treatment‐Induced Neuroendocrine Differentiation in Prostate Cancer
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  65. PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinoma
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    BindingDB · 2020 · UC San Diego
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