The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity
Open accessAbstract
Secretory IgA (SIgA) antibodies represent the first line of antigen-specific immune defense protecting the mucosal surfaces against environmental pathogens and antigens, and maintaining homeostasis with the commensal microbiota. The polymeric immunoglobulin receptor (pIgR) has the dual role of transporting locally produced dimeric IgA across mucosal epithelia, and serving as the precursor of secretory component, a glycoprotein that enhances the immune functions of SIgA. The complex regulation of pIgR expression and transcytosis by host and microbial factors is finely tuned to optimize the role of SIgA in mucosal immunity. Disruption of this regulatory network in disease states similar to inflammatory bowel disease can result in profound consequences for mucosal homeostasis and systemic sequelae. Future research into the function and regulation of pIgR and SIgA may offer new insights into the prevention and treatment of infectious and inflammatory diseases that originate at mucosal surfaces.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Johansson, M. E. V., Larsson, J. M. H., & Hansson, G. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006451107 · Cited by 1,452
Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
Mantis, N. J., Rol, N., & Corthésy, B. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.41 · Cited by 1,283
The immune geography of IgA induction and function
Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2008) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,028
Self-citationReversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses
Hapfelmeier, S., Lawson, M. A. E., Slack, E., Kirundi, J. K., Stoel, M., Heikenwalder, M., Cahenzli, J., Velykoredko, Y., Balmer, M. L., Endt, K., et al. (2010) · Science · doi:10.1126/science.1188454 · Cited by 835
Kaetzel, C. S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00278.x · Cited by 582
Self-citationMembrane traffic in polarized epithelial cells
Mostov, K. E., Verges, M., & Altschuler, Y. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00120-4 · Cited by 377
Swidsinski, A. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i8.1131 · Cited by 314
Immunoglobulin transport across polarized epithelial cells
Rojas, R., & Apodaca, G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm972 · Cited by 309
Cited by
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature Reviews Immunology · doi:10.1038/nri3608 · Cited by 3,173
Rogier, E. W., Frantz, A. L., Bruno, M. E. C., Wedlund, L., Cohen, D. A., Stromberg, A. J., & Kaetzel, C. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315792111 · Cited by 485
Self-citationImplication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases
Stolfi, C., Maresca, C., Monteleone, G., & Laudisi, F. (2022) · Biomedicines · doi:10.3390/biomedicines10020289 · Cited by 339
The Effects of Secretory IgA in the Mucosal Immune System
Li, Y., Jin, L., & Chen, T. (2020) · BioMed Research International · doi:10.1155/2020/2032057 · Cited by 336
Tear analysis in ocular surface diseases
Zhou, L., & Beuerman, R. W. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.002 · Cited by 318
Metadata
- Authors
- Johansen, F.-E., & Kaetzel, C. S.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 4
- Issue
- 6
- Pages
- 598-602
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2048814693
- Cited by
- 368
- References
- 23
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. https://app.cochat.ai/papers/10.1038/mi.2011.37
- The paper
- Johansen, F.-E., & Kaetzel, C. S. (2011). Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunology. https://doi.org/10.1038/mi.2011.37
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
