A theoretical molecular network for dyslexia: integrating available genetic findings.
Abstract
Developmental dyslexia is a common specific childhood learning disorder with a strong heritable component. Previous studies using different genetic approaches have identified several genetic loci and candidate genes for dyslexia. In this article, we have integrated the current knowledge on 14 dyslexia candidate genes suggested by cytogenetic findings, linkage and association studies. We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I, DYX1C1 and DCDC2) fit into a theoretical molecular network involved in neuronal migration and neurite outgrowth. Based on this, we also propose three novel dyslexia candidate genes (SLIT2, HMGB1 and VAPA) from known linkage regions, and we discuss the possible involvement of genes emerging from the two reported genome-wide association studies for reading impairment-related phenotypes in the identified network.
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Disruptions of neuronal migration and neurite outgrowth contribute importantly to the pathogenesis of dyslexia.
“The molecular pathophysiology of dyslexia is less understood, but lines of evidence suggest that disruptions of neuronal migration and neurite outgrowth contribute importantly to the pathogenesis of the disease (Poelmans et al., 2011; Shao et al., 2016; Guidi et al., 2018).”
From Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development (2020) · cites this paper as Poelmans et al., 2011
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An essential receptor for adeno-associated virus infection
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Huang, M., Liang, C., Li, S., Zhang, J., Guo, D., Zhao, B., Liu, Y., Peng, Y., Xu, J., Liu, W., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00577 · Cited by 41 · see citing works
“Among them, Dock4 has attracted recent attention as emerging evidence suggests DOCK4 as a candidate gene for several neuropsychiatric diseases, including autism spectrum disorder (ASD), dyslexia and schizophrenia (Maestrini et al., 2010; Pagnamenta et al., 2010; Poelmans et al., 2011; Alkelai et al., 2012; Iossifov et…”
BackgroundNeurobiological Sex Differences in Developmental Dyslexia
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- Authors
- Poelmans, G., Buitelaar, J. K., Pauls, D. L., & Franke, B.
- Affiliations
- Radboud University Medical Center (NL)
- Harvard University (US)
- Radboud University Nijmegen (NL)
- Corresponding author
- Franke, B
- Venue
- Molecular Psychiatry
- Published
- 2010-10-19
- Volume
- 16
- Issue
- 4
- Pages
- 365-382
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2170334861
- Cited by
- 119
- References
- 1
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 18 · 2012: 12
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- developmental dyslexia, molecular networks, neuronal migration, neurite outgrowth, ROBO1, KIAA0319, S100B, DOCK4, FMR1 gene, GTF2I, DYX1C1, DCDC2, Slit2, HMGB1, VAPA, reading disorders, genetic loci, heritability
- MeSH terms
- Dyslexia, Humans, Genetic Linkage, Nerve Tissue Proteins, Psychometrics, Meta-Analysis as Topic, Genetic Predisposition to Disease, Genome-Wide Association Study
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