Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study
Howes, O, Bose, S, Turkheimer, F, Valli, I, Egerton, A, Stahl, D, Valmaggia, L, Allen, P +2 more·2011·Molecular Psychiatry
Cited by (292)
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- Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodromeAlice E. Petty, Xiaoying Cui, Asad Amanat Ali, Zilong Du, Sunil Srivastav, James P. Kesby, Deniz Kirik, Oliver David Howes, Darryl Walter Eyles · 2021 · Scientific Reports
- Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in PsychosisI. Bonoldi, O. Howes · 2014 · CNS Drugs
- Possible Biomarkers and Contributing Factors of Psychosis: a ReviewMonu Yadav, Naresh Kumar, Anil Kumar, Deepak Kumar Jindal, Mini Dahiya · 2021 · Current Pharmacology Reports
- Neuroimaging studies in people at clinical high risk for psychosisGeorge Gifford, Robert Ali McCutcheon, Philip K. McGuire · 2020 · Elsevier eBooks
- Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis RiskCathy Davies, Matthijs Geert Bossong, Daniel Martins, Robin Paul Wilson, Elizabeth Appiah‐Kusi, Grace Blest‐Hopley, Paul Allen, Fernando O. Zelaya, David J. Lythgoe, Michael John Brammer et al. · 2023 · Schizophrenia Bulletin Open
- Is treatment-resistance in psychiatric disorders a trap for polypharmacy?Miroslava Jašović‐Gašić · 2015 · PubMed
- GABA Dysfunction in Schizophrenia: The GABAA Receptor as a Potential Therapeutic TargetBrandon L. M. Crotchett, Seth D. Reighard, Henry A. Nasrallah · 2025 · Biomarkers in Neuropsychiatry
- Delusions: Understanding the Un-understandablePeter J. McKenna · 2017
- Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny NeuronsAna Montaño-Rodriguez, Tabea Schorling, Jaan‐Olle Andressoo · 2024 · Cells
- Personalisierte Medizin in der Psychiatrie und PsychotherapieNikolaos Koutsouleris, Stephan Ruhrmann, Peter Falkai, Wolfgang Maier · 2013 · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
- Translating neuroimaging findings into psychiatric practiceThomas James Reilly, Philip K. McGuire · 2013 · The British Journal of Psychiatry
- Radiomic Analysis of Striatal [18F]FDOPA PET Imaging in Patients with Psychosis for the Identification of Antipsychotic ResponseAstrid Schiulaz, Giovanna Nordio, Alessio Giacomel, Rubaida Easmin, Andrea Bettinelli, Pierluigi Selvaggi, Steven Williams, Federico Turkheimer, Sameer Jauhar, Oliver David Howes et al. · 2025 · Molecular Imaging and Biology
- The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusionsMaria M. Margariti, Ilias I. Vlachos · 2022 · Medical Hypotheses
- Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With SchizophreniaManabu Kubota, Keisuke Takahata, Kiwamu Matsuoka, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Ryosuke Tarumi, Hisaomi Suzuki, Shin Kurose, Shinichiro Nakajima et al. · 2022 · Schizophrenia Bulletin
- Reversal learning in those with early psychosis features contingency-dependent changes in loss response and learningAndrea Baker, Shuichi Suetani, Peter Cosgrove, Dan J. Siskind, Graham K. Murray, James G. Scott, James P. Kesby · 2023 · Cognitive Neuropsychiatry
- Maternal Nutritional Deficiencies and SchizophreniaDarryl Walter Eyles, Angela J. Dean · 2015 · Handbook of behavioral neuroscience
- Dexamphetamine influences funneling illusion based on psychometric scoreFaiz Mohammed Kassim, J. H. Mark Lim, Matthew A. Albrecht, Mathew Thomas Martin-Iverson · 2023 · Human Psychopharmacology Clinical and Experimental
- Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male miceKyna‐Anne Conn, Simin Zou, Joyosmita Das, S Alexander, Thomas H.J. Burne, James P. Kesby · 2023 · Neuropharmacology
- Sollen bei Prodromalstadien der Schizophrenie Antipsychotika zur Psychoseprävention eingesetzt werden? ProMartin Lambert, Christoph Ulrich Correll · 2015 · Der Nervenarzt
- Suppression of the dorsomedial striatum impairs reversal learning in response to probabilistic uncertainty and disrupts corticostriatal function in miceKyna‐Anne Conn, Joyosmita Das, S Alexander, Thomas H.J. Burne, James P. Kesby · 2025 · Neuropharmacology
- The Association Between Childhood Impaired Motor Development and Adolescent Psychotic ExperiencesPauline C. M. Hamers, Diandra C. Bouter, Sieds Dieleman, Witte J.G. Hoogendijk, Nina H. Grootendorst–van Mil · 2025 · Developmental Psychobiology
- Imagerie cérébrale et déconstruction de l’espritRenaud de Beaurepaire · 2016 · L Évolution Psychiatrique
- Dopamine manipulations modulate paranoid social inferences in healthy peopleJoseph M Barnby, Vaughan Bell, Quinton Deeley, Mitul Ashok Mehta · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Individual and combined effects of Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) on striato-cortical connectivity in the human brainMatthew B. Wall, Tom P. Freeman, Chandni Hindocha, Lysia Demetriou, Natalie Ertl, Abigail M. Freeman, A. Jones, Will Lawn, Rebecca Anne Pope, Claire Mokrysz et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosisSamuel Knight, Leyla Abbasova, Yashar Zeighami, Justine Y. Hansen, Daniel Martins, Fernando O. Zelaya, Ottavia Dipasquale, T. Liu, D. Shin, Matthijs Geert Bossong et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Refining mechanistic models of hallucinations for enhanced translatabilityJustin Buck, Kiyohito Iigaya, Guillermo Horga · 2025 · Translational Psychiatry
- The utility of PET imaging in the diagnosis and management of psychosis: a brief reviewGrant Harding Rigney, Cyrus Ayubcha, Thomas J. Werner, Abass A. Alavi, Mona-Elisabeth R. Revheim · 2021 · Clinical and Translational Imaging
- Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in SchizophreniaMathew V. Chafee · 2022 · Current topics in behavioral neurosciences
- Elucidating gut microbiota–hippocampus interactions in emerging psychosis: A new perspective for the development of early interventions for memory impairmentsGalya Clara Iseli, Sarah Ulrich, André Schmidt · 2023 · Frontiers in Psychiatry
- A comprehensive update on genetic inheritance, epigenetic factors, associated pathology, and recent therapeutic intervention by gene therapy in schizophreniaR. R., Harshit Devtalla, Karishma Rana, S. Panda, Arushi Agrawal, Shreya Kadyan, Divya Jindal, Pranav Pancham, Deepshikha Yadav, N. Jha et al. · 2023 · Chemical Biology and Drug Design
- The Anatomy of DelusionGeorges Naasan · 2016 · Elsevier eBooks
- Predicting Outcome in Schizophrenia: Neuroimaging and Clinical AssessmentsNancy C. Andreasen, Thomas Nickl‐Jockschat · 2020 · Springer eBooks
- Dopamine and Response to Antipsychotic MedicationChukwuma Ntephe, Arsime Demjaha · 2020 · Springer eBooks
- The neuromediator mechanisms of the cognitive deficit in schizophreniaZinaida I. Storozheva, Anna V. Kirenskaya, Andrey T. Proshin · 2015 · Neurochemical Journal
- Erratum zu: Sollen bei Prodromalstadien der Schizophrenie Antipsychotika zur Psychoseprävention eingesetzt werden? ProMartin Lambert, Christoph Ulrich Correll · 2016 · Der Nervenarzt
- Mesocorticolimbic circuit mechanisms underlying the effects of ketamine on dopamine: a translational imaging studyMichelle Kokkinou, Elaine E. Irvine, David R. Bonsall, Sridhar Natesan, Lisa A. Wells, Mark Smith, Justyna A. Glegola, Eleanor J. Paul, Kyoko Tossell, Mattia Veronese et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- The dopaminergic basis of negative symptoms in schizophrenia: an addendumAna Weidenauer, I. Dajić, N. Praschak-rieder, Matthaeus Willeit · 2024 · Molecular Psychiatry
- Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [ 18 F]DOPA PET in Naïve and Cocaine-Treated MiceDavid R. Bonsall, Michelle Kokkinou, Els F. Halff, Grazia Rutigliano, Sac-Pham Tang, Mattia Veronese, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Sridhar Natesan et al. · 2024 · Molecular Imaging
- Halved Dose of Antipsychotics Versus High-Dose Antipsychotic Therapy for Relapse in Patients with Schizophrenia Receiving High-Dose Antipsychotic Therapy: A Randomized Single-Blind TrialRyota Ataniya, Takeshi Koike, Atsuko Inamoto · 2025 · International Journal of Molecular Sciences
- Dopamine synthesis capacity in patients with remitted psychosis: correlates and one year outcome on relapseChristy Lai Ming Hui, Charlie Cheuk Lam Wong, Nicole Cai Lin Yang, E. G. Choi, Priscilla Wing Man Hui, Eric Lui, J Tao, Elise Chun‐Ning Ho, Yi Nam Suen, Sirong Chen et al. · 2026 · European Archives of Psychiatry and Clinical Neuroscience
- SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosisRami Hamati, Nour Kanaa, Bianca Chidiac, Synthia Guimond, Clifford Cassidy, Lauri J. Tuominen · 2026 · Schizophrenia
- Static and dynamic alterations of local brain activity in schizophrenia and associations with clinical symptoms and cognitive functionShuzhe Wang, Peiwen Ren, Chenghao Lu, Xiaofei Zhang, Yeqing Dong, Feng Liu, Shen Li, Jie Li · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- SchizophreniaBart A. Ellenbroek, Jiun Youn · 2016 · Elsevier eBooks
- Stati mentali a rischio di psicosi: identificazione e strategie attuali di trattamento [translation of “At-risk mental state for psychosis: identification and current treatment approaches” by Dr. Giulia Rioli]Andrew David Thompson, Steven Marwaha, Matthew R. Broome · 2016 · BJPsych Advances
- Correlation Between Intellectual Function and Relapse of Schizophrenia Regarding Dose Reduction in Patients Undergoing High-Dose Antipsychotic TherapyRyota Ataniya, MIKIRO SAITO, Tadashi Takahashi · 2017 · Juntendō Igaku/Juntendo igaku
- Models of Schizophrenia. A Selective Review of Genetic, Neuropharmacological, Cognitive, and Social ApproachesMegan C. Ichinose, Sohee Park · 2019 · Elsevier eBooks
- Not all stress is created equal: Acute, not ambient stress, impairs learning in high schizotypesEmma E. Walter, Francesca Fernandez, Emma Barkus · 2021 · PsyCh Journal
- Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implicationsG. De Simone, M. De Prisco, Vincenzo Oliva, L. Vellucci, M. Ciccarelli, B. Mazza, G. Fico, M. Fornaro, F. Iasevoli, E. Vieta et al. · 2025 · Molecular Psychiatry
- Dopamine and the Biology and Course of Treatment ResistanceArsime Demjaha, Oliver David Howes · 2014 · Springer eBooks
- Brain PET Poster Sessions PP01-M01 to PP02-N07D. Lange, Isabel Martinez Tejada, M. xiong, B. Hillebrand, M. Noergaard, S. Baerentzen, Vladimir Shalgunov, M. M. Herth, C. Svarer, M. Palner · 2019 · Journal of Cerebral Blood Flow & Metabolism
- Molecular ImagingSimon Červenka, Lars Farde · 2020 · Springer eBooks
- Magnetic Resonance and Molecular Imaging in PsychiatryOliver David Howes · 2015 · Elsevier eBooks
- Studying biomarkers in populations at genetic and clinical high risk for psychosisMariken Beatrijs de Koning · 2013
- Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy ControlsKristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Álvarez‐Jiménez et al. · 2021 · medRxiv
- Enhanced dopamine in prodromal schizophrenia (EDiPS): a new animal model of relevance to schizophreniaAlice E. Petty · 2019 · The University of Queensland
- An Egg & Chicken Paradox: Are changes in the Basal ganglia volume the reason for or the result of Schizophrenia?Ümit Haluk Yeşilkaya, Meltem Sen, Neslihan Yüzbaşıoğlu, Kadriye Betül Pençe, Nesrin Karamustafalıoğlu · 2023
- Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal functionLeonardo Sportelli, Daniel Paul Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda Antonella Antonucci, Qiang Chen, Jasmine Czarapata, Aaron L. Goldman, Michael A. Gregory, Kira Griffiths et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Investigating Dopaminergic Abnormalities in Psychosis with Normative Modelling and Multisite Molecular NeuroimagingAlessio Giacomel, Daniel Martins, Giovanna Nordio, Rubaida Easmin, Oliver David Howes, Pierluigi Selvaggi, Steven Williams, Federico Turkheimer, Marius de Groot, Ottavia Dipasquale et al. · 2023 · medRxiv
- A single dose of cannabidiol modulates the coupling between hippocampal glutamate and learning-related prefrontal activation in individuals at Clinical High Risk of PsychosisYiling Shi, Cathy Davies, Robin Paul Wilson, Elizabeth Appiah‐Kusi, David J. Lythgoe, Gemma Modinos, Sagnik Bhattacharyya · 2024 · medRxiv
- Epidemiological and biological mechanisms of cannabis as cause of psychosisRebecca Kuepper · 2012
- Aspectos metodológicos para la evaluación de sistemas de tomografía por emisión de positrones empleando técnicas Montecarlo, protocolos estandarizados y diferentes trazadoresMario Cañadas Castro · 2012
- Is dopamine still the key to treating schizophrenia?Steve Titmarsh · 2013 · Progress in Neurology and Psychiatry
- psychosisdysfunction in people with prodromal or first-episodeD Howes, Valeria Mondelli, Heather Taylor, Marta Di Forti, Philip K. McGuire, Robin M. Murray, Oliver Tiago Reis Marques, Stefania Bonaccorso, Fiona Gaughran, Anna Kolliakou · 2012
- Authors' replyOliver David Howes, Siobhan Gee, David M. Taylor · 2013 · The British Journal of Psychiatry
- Brain imaging and the deconstruction of mindRenaud de Beaurepaire · 2016 · L Évolution Psychiatrique
- Altered Neural Synchronies Underlying Cognitive Deficits in a Transgenic Mouse Model of Huntington’s DiseaseYoon H. Cho, Yannick Jeantet · 2015 · Springer eBooks
- of imaging studies function in schizophrenia: systematic review and meta-analysis Alterations in cortical and extrastriatal subcortical dopamineJoseph P. Kambeitz, Anissa Abi‐Dargham, Shitij Kapur, Oliver David Howes · 2014
- The Effects of Atypical Antipsychotics on Implicit Reward Learning in SchizophreniaLisa Bradford · 2015 · QSpace (Queen's University Library)
- translating research evidence into clinical utility Third-generation neuroimaging in early schizophrenia:Stefan Borgwardt, Paolo Fusar‐Poli · 2012
- Do antipsychotic drugs improve working memory impairment caused by increased dopamine release during relapse phases of schizophrenia?Ryota Ataniya · 2018 · Asia Pacific Journal of Clinical Trials Nervous System Diseases
- Neuroimaging and AntipsychoticsAntonio Vita, Florian Schlagenhauf, Stefano Barlati, Andreas Heinz · 2019 · Springer eBooks
- Structural and functional neuroimaging of schizophreniaAndreea Oliviana Diaconescu, Sandra Iglesias, Klaas Enno Stephan · 2020
- P.503 Positive symptom phenotypes appear progressively in "enhanced dopamine in prodromal schizophrenia", a new animal model of the schizophrenia prodromeAlice E. Petty, Xiaoying Cui, Asad Amanat Ali, Oliver David Howes, Darryl Walter Eyles · 2020 · European Neuropsychopharmacology
- Induced pluripotent stem cells in psychiatry: a critical reviewAlejandro De Los Angeles, Kristen Brennand, Nicola Hall, Michael B. Fernando, Paul J. Harrison, Brady J. Maher, Daniel R. Weinberger, Elizabeth M. Tunbridge · 2021
- Psychotic DisordersJames G. Scott, Bjorn Burgher · 2020 · The Encyclopedia of Child and Adolescent Development
- A volumetric dilemma: Large basal ganglia in medication-naive first episode psychosisÜmit Haluk Yeşilkaya, Melten Sen, Neslihan Yüzbaşıoğlu, Kadriye Betül Pençe, Nesrin Karamustafalıoğlu · 2022 · Research Square
- Halved dose of antipsychotics versus symptomatic treatment for relapse in patients with schizophrenia receiving high-dose antipsychotic therapy: a randomized single-blind trialRyota Ataniya, Ken Koike, Atsuko Inamoto · 2022 · Research Square
- An insight into the acute effects of cannabidiol on human brain function and their relationship with the brain expression of its molecular targets: a neuroimaging meta-regression analysisBrandon Gunasekera, Cathy Davies, Grace Blest‐Hopley, Robin Paul Wilson, Geraldo F. Busatto, José Alexandre S. Crippa, Fábio Duran, Antônio Waldo Zuardi, Mattia Veronese, Joaquim Raduà et al. · 2022 · Research Square
- Enlarged basal ganglia in drug-naïve patients with first-episode psychosis immediately upon symptom onsetÜmit Haluk Yeşilkaya · 2024 · Dusunen Adam The Journal of Psychiatry and Neurological Sciences
- Bridging the Phenomenology of Prodromal Psychosis with Its Underlying Neurobiological MechanismsScott Schobel · 2024 · Springer eBooks
- The Role of the Immune System in Creating Depression, Post-traumatic-Stress-Disorder, and PsychosisJill Leslie Littrell · 2024 · Integrated science
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- Excess GDNF associates with a subtype of schizophrenia with enhanced dopamine and increased prefrontal dysfunctionIsabel Runneberger, Daniel R. Garton, Peyman Choopanian, Ana Montaño-Rodriguez, Mehdi Mirzaie, Funda Orhan, Vladislav Yakimov, Joanna Moussiopoulou, Vilma Iivanainen, Soophie Olfat et al. · 2025 · medRxiv
- A single dose of cannabidiol modulates the relationship between hippocampal glutamate and learning-related prefrontal activation in individuals at Clinical High Risk of PsychosisYiling Shi, Cathy Davies, Robin Paul Wilson, Elizabeth Appiah‐Kusi, David J. Lythgoe, Gemma Modinos, Sagnik Bhattacharyya · 2025 · Psychiatry Research Neuroimaging
- Structural and functional cerebral changes in patients with schizophrenia and genetic risk-allele carriersJoseph P. Kambeitz · 2014 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
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