The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

Walker, A K, Rivera, P D, Wang, Q, Chuang, J-C, Tran, S, Osborne-Lawrence, S, Estill, S J, Starwalt, R +8 more·2015·Molecular Psychiatry

Cited by (162)

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    Oskar Sosinski, Ewa Pruszyńska‐Oszmałek, Natalia Leciejewska, Maciej Sassek, Pawel Antoni Kolodziejski · 2025 · International Journal of Molecular Sciences
  8. P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson’s disease
    Yajing Chen, Zengyan Zhu, Yinghui Yan, Hongyang Sun, Guanghui Wang, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Mei Wang et al. · 2024 · CNS Neuroscience & Therapeutics
  9. Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice
    Martin K. Wellman, Zachary R. Patterson, Harry MacKay, Joseph E. Darling, Bharath Kumar Mani, Jeffrey Marc Zigman, James L. Hougland, Alfonso B. Abizaid · 2015 · Frontiers in Endocrinology
  10. Neuroprotective effects of P7C3 against spinal cord injury in rats
    Fei‐Xiang Duan, Yujiao Shi, Jing Chen, Shu‐Qin Ding, Fengchao Wang, Tang Jie, Rui Wang, Lin Shen, Jianguo Hu, Qi Qi et al. · 2019 · Experimental Biology and Medicine
  11. Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress
    Rachel E. Schroeder, Lynn T. Nguyen, Andrew A. Pieper, Hanna Elizabeth Stevens · 2021 · Behavioural Brain Research
  12. Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
    Martina Sassi, A. Morgan, J. Davies · 2022 · Cells
  13. Druggable Transcriptional Networks in the Human Neurogenic Epigenome
    Gerald A. Higgins, Aaron M. Williams, Alex S. Ade, Hasan Badre Alam, Brian D. Athey · 2019 · Pharmacological Reviews
  14. Strain Differences in Responsiveness to Repeated Restraint Stress Affect Remote Contextual Fear Memory and Blood Transcriptomics
    Seung Ho Jung, Jeanie K. Meckes, Matthew John Schipma, Patrick H. Lim, Sophia T. Jenz, Katherine J. Przybyl, Stephanie L. Wert, Sarah Y. Kim, Wendy Luo, Stephanie A. Gacek et al. · 2020 · Neuroscience
  15. Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating
    Bharath Kumar Mani, Carlos M. Castorena, Claudia Regina Vianna, Charlotte E. Lee, Nathan P. Metzger, Prasanna Vijayaraghavan, Sherri L. Osborne-Lawrence, Joel Keith Elmquist, Jeffrey Marc Zigman · 2019 · Neuroscience
  16. Cucurbitacin B Exerts Significant Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Model of Depression: Involvement of the Hippocampal BDNF-TrkB System
    Jianbin Ge, Bo Jiang, Tian-Shun Shi, Weiyu Li, Weijia Chen, Bao-Lun Zhu, Zheng‐Hong Qin · 2023 · The International Journal of Neuropsychopharmacology
  17. Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
    D. Borroto-Escuela, Pedro Serrano Castro, Jose Andrés Sánchez-Pérez, Miguel Angel Barbancho-Fernández, K. Fuxe, Manuel Narváez · 2024 · Expert opinion on therapeutic targets
  18. Ghrelin’s role in sleep and sleep deprivation: a narrative review
    M. Ditmer, A. Wojtera, A. Gabryelska, S. Turkiewicz, P. Białasiewicz, D. Strzelecki, M. Sochal · 2026 · Frontiers in Psychiatry
  19. Gut feelings about depression
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  20. The Protective effect of P7C3 against DNA and neuron damage in rat pups with congenital hypothyroidism
    Halef Okan Doğan, Mehmet Eray Alçığır · 2018 · Biomedicine & Pharmacotherapy
  21. A Potential Strategy for Treatment of Neurodegenerative Disorders by Regulation of Adult Hippocampal Neurogenesis in Human Brain
    Wei-Song Xie, Kiran Shehzadi, Hong-Le Ma, Jian‐Hua Liang · 2022 · Current Medicinal Chemistry
  22. Discovery of Novel Diphenyl Acrylonitrile Derivatives That Promote Adult Rats’ Hippocampal Neurogenesis
    Sisi Liu, Cong-Xuan Ma, Zhengyang Quan, Jing Ding, Liang Yang, Simeng Liu, Heao Zhang, Hong Qing, Jian‐Hua Liang · 2024 · International Journal of Molecular Sciences
  23. Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications
    Xingli Pan, Yuxin Gao, Kaifu Guan, Jing Chen, Bingyuan Ji · 2024 · Current Issues in Molecular Biology
  24. How Does the P7C3-Series of Neuroprotective Small Molecules Prevent Membrane Disruption?
    Amin Reza Zolghadr, Maryam Heydari Dokoohaki · 2017 · Journal of Chemical Information and Modeling
  25. Dissecting the pro-neurogenic effects of monoaminergic medications used to treat depression: a systematic review and meta-analysis
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  26. Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging
    Jing Tian, Eric Du, Kun Jia, Tien-Ju Wang, Lan Guo, J. Zigman, Heng Du · 2023 · Journal of Alzheimer's Disease
  27. Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study
    Dirk Alexander Wittekind, Jürgen Kratzsch, Roland Mergl, Kerstin Wirkner, Ronny Baber, Christian Sander, A. Veronica Witte, Arno Villringer, Michael Kluge · 2023 · Translational Psychiatry
  28. Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis
    Shu Ge, Wenjin Chen, Chenchen Huang, Hui Shan, Jing Ye, Jianfa Li, Yaoting Gui · 2024 · Journal of Cancer
  29. Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer’s Disease: A Therapeutic Review
    Manita Saini, Seema Rohilla, Rakesh Kumar · 2025 · Current Aging Science
  30. P7C3-A20 prevents whole brain radiotherapy-induced chronic hippocampal redox imbalance and neuropsychiatric impairment in mice
    Edwin Vázquez‐Rosa, Min‐Kyoo Shin, Kalyani Chaubey, Sarah Barker, Sofia G. Corella, Suwarna Chakraborty, Sunil Jamuna Tripathi, Youngmin Yu, Jiwon Hyung, Himanshu R. Dashora et al. · 2026 · Redox Biology
  31. Expression of ghrelin or growth hormone secretagogue receptor in the brain of postpartum stress mice
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  32. Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau
    Pierfausto Seneci · 2015 · Elsevier eBooks
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    Matija Šestan-Peša, Marya Shanabrough, Tamás L. Horváth, Maria Consolata Miletta · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
    Jeskanen, Heli, Heikkinen, Sami, Kervinen, Inka, Lehtisalo, Jenni, Ngandu, Tiia, Willman, Roosa-Maria, Rosa, Jessica, Hoffmann, Dorit, FinnGen, Leinonen, Ville et al. · 2026 · Alzheimer's Research & Therapy
  35. Depression and Anxiety After Radiation-Induced Brain Injury: A Review of Current Research Progress
    Feng Yang, Rundong Liu, Xiaohong Peng, Na Luo, Min Fu, Wenjun Zhu, Qianxia Li, Guangyuan Hu · 2025 · Current Oncology
  36. GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice
    R. Stark, J. Zigman, Z. Andrews · 2025 · Journal of neuroendocrinology
  37. Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease
    Xinyi Zhou, Jialin Han, Xiaolin Cui, Shuang Wu, Zhiming Lu, Shuai Zong · 2026 · Journal of Translational Medicine
  38. Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1
    Jan Zítko, Martin Doležal · 2015 · Expert Opinion on Therapeutic Patents
  39. Correction of neurogenesis in the adult brain: Selection of therapeutic targets
    О. А. Гомазков · 2017 · Neurochemical Journal
  40. Study of the effects of the ghrelin-associated peptide obestatin on stress-related behaviors
    Júlia Szakács · 2017
  41. Neuroprotective strategies for traumatic brain injury
    Terry C. Yin · 2015
  42. Ghrelin Resistance: A Possible Mechanism Underlying Antidepressant-Induced Obesity?
    Jinhong Ma, Zhi-Gang Wang, Bin Zhu · 2016 · Journal of Child and Adolescent Psychopharmacology
  43. Leptin And Ghrelin – The New Old Players In Obesity And Depression
    Rositsa V. Sandeva, Stanislava M. Mihaylova, Gergana N. Sandeva · 2014 · Journal of Biomedical and Clinical Research
  44. Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models
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  45. Antidépresseurs : aspects pharmacologiques
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  46. The Neuroprotective Compound P7C3-A20 Promotes Neurogenesis and Improves Functional Outcomes After Focal Cerebral Ischemia
    Zachary B. Loris · 2017
  47. The Behavioural, Neuroanatomical, and Molecular Effects of Chronic Social Stress on Mice That Lack Zinc Transporter 3 and Vesicular Zinc
    Brendan B. McAllister · 2018 · Libraries and Cultural Resources (University of Calgary)
  48. The Role of Ghrelin and Ghrelin O-Acyltransferase in Obesity: Targets for Treatment
    Martin K. Wellman · 2016
  49. CEE et agrobiologie: le grand tournant
    François Roelants du Vivier · 1988 · Nature et progrès
  50. βCaMKII overexpression in the dentate gyrus does not result in depression- and anxiety-like behaviors in mice
    Juzhe Xi, Pengcheng Yin, Yu Jeong Kang, Gal Richter‐Levin, Kaiwen Zhang, Xiaohua Cao, Yao Liu, Yanhong Duan · 2022 · Stress and Brain
  51. Correlation of adult neurogenesis and cognitive performance in touchscreen tasks – assessing the novel small molecule OXS-N1 in mice
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  52. The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriers
    H. Jeskanen, S. Heikkinen, I. Kervinen, J. Lehtisalo, T. Ngandu, R.-M. Willman, J. Rosa, D. Hoffmann, FinnGen, V. Leinonen et al. · 2025 · medRxiv
  53. Antidépresseurs : aspects pharmacologiques
    Moussa A. Chalah, Raphaël Gaillard B · 2025 · Encyclopédie médico-chirurgicale. Psychiatrie
  54. Central liver-expressed antimicrobial peptide 2 induces anxiety- and depression-related behaviors and activates the hypothalamic-pituitary-adrenal axis in male mice
    Maximilian Tufvesson‐Alm, Elisabet Jerlhag · 2026 · Hormones and Behavior
  55. Rôle de la neurogenèse hippocampique adulte dans la résilience au stress : étude dans deux modèles murins de stress aigu et chronique
    Barbara Planchez · 2021 · theses.fr (ABES)
  56. Fasting ghrelin as mediator between obesity and depressive symptoms: a pre-registered study
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  57. Norisoboldine inhibits endoplasmic reticulum stress and alleviates depressive behaviors in CUMS mice by activating growth hormone secretagogue receptor type 1a in the hippocampus
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  59. P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders
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  62. BindingDB Entry 50044309: Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.
    BindingDB · 2015 · UC San Diego