The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis
Walker, A K, Rivera, P D, Wang, Q, Chuang, J-C, Tran, S, Osborne-Lawrence, S, Estill, S J, Starwalt, R +8 more·2015·Molecular Psychiatry
Cited by (162)
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- Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in MiceMartin K. Wellman, Zachary R. Patterson, Harry MacKay, Joseph E. Darling, Bharath Kumar Mani, Jeffrey Marc Zigman, James L. Hougland, Alfonso B. Abizaid · 2015 · Frontiers in Endocrinology
- Neuroprotective effects of P7C3 against spinal cord injury in ratsFei‐Xiang Duan, Yujiao Shi, Jing Chen, Shu‐Qin Ding, Fengchao Wang, Tang Jie, Rui Wang, Lin Shen, Jianguo Hu, Qi Qi et al. · 2019 · Experimental Biology and Medicine
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- Strain Differences in Responsiveness to Repeated Restraint Stress Affect Remote Contextual Fear Memory and Blood TranscriptomicsSeung Ho Jung, Jeanie K. Meckes, Matthew John Schipma, Patrick H. Lim, Sophia T. Jenz, Katherine J. Przybyl, Stephanie L. Wert, Sarah Y. Kim, Wendy Luo, Stephanie A. Gacek et al. · 2020 · Neuroscience
- Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or EatingBharath Kumar Mani, Carlos M. Castorena, Claudia Regina Vianna, Charlotte E. Lee, Nathan P. Metzger, Prasanna Vijayaraghavan, Sherri L. Osborne-Lawrence, Joel Keith Elmquist, Jeffrey Marc Zigman · 2019 · Neuroscience
- Cucurbitacin B Exerts Significant Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Model of Depression: Involvement of the Hippocampal BDNF-TrkB SystemJianbin Ge, Bo Jiang, Tian-Shun Shi, Weiyu Li, Weijia Chen, Bao-Lun Zhu, Zheng‐Hong Qin · 2023 · The International Journal of Neuropsychopharmacology
- Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorderD. Borroto-Escuela, Pedro Serrano Castro, Jose Andrés Sánchez-Pérez, Miguel Angel Barbancho-Fernández, K. Fuxe, Manuel Narváez · 2024 · Expert opinion on therapeutic targets
- Ghrelin’s role in sleep and sleep deprivation: a narrative reviewM. Ditmer, A. Wojtera, A. Gabryelska, S. Turkiewicz, P. Białasiewicz, D. Strzelecki, M. Sochal · 2026 · Frontiers in Psychiatry
- Gut feelings about depressionAlfonso B. Abizaid, Hymie Anisman · 2014 · Journal of Psychiatry and Neuroscience
- The Protective effect of P7C3 against DNA and neuron damage in rat pups with congenital hypothyroidismHalef Okan Doğan, Mehmet Eray Alçığır · 2018 · Biomedicine & Pharmacotherapy
- A Potential Strategy for Treatment of Neurodegenerative Disorders by Regulation of Adult Hippocampal Neurogenesis in Human BrainWei-Song Xie, Kiran Shehzadi, Hong-Le Ma, Jian‐Hua Liang · 2022 · Current Medicinal Chemistry
- Discovery of Novel Diphenyl Acrylonitrile Derivatives That Promote Adult Rats’ Hippocampal NeurogenesisSisi Liu, Cong-Xuan Ma, Zhengyang Quan, Jing Ding, Liang Yang, Simeng Liu, Heao Zhang, Hong Qing, Jian‐Hua Liang · 2024 · International Journal of Molecular Sciences
- Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic ImplicationsXingli Pan, Yuxin Gao, Kaifu Guan, Jing Chen, Bingyuan Ji · 2024 · Current Issues in Molecular Biology
- How Does the P7C3-Series of Neuroprotective Small Molecules Prevent Membrane Disruption?Amin Reza Zolghadr, Maryam Heydari Dokoohaki · 2017 · Journal of Chemical Information and Modeling
- Dissecting the pro-neurogenic effects of monoaminergic medications used to treat depression: a systematic review and meta-analysisJuliana Aparecida Bolzan, Tamires Martins, Karolina Domingues, Alexandre Surget, Catherine Belzung, Cilene Lino de Oliveira · 2025 · Journal of Psychopharmacology
- Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During AgingJing Tian, Eric Du, Kun Jia, Tien-Ju Wang, Lan Guo, J. Zigman, Heng Du · 2023 · Journal of Alzheimer's Disease
- Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based studyDirk Alexander Wittekind, Jürgen Kratzsch, Roland Mergl, Kerstin Wirkner, Ronny Baber, Christian Sander, A. Veronica Witte, Arno Villringer, Michael Kluge · 2023 · Translational Psychiatry
- Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasisShu Ge, Wenjin Chen, Chenchen Huang, Hui Shan, Jing Ye, Jianfa Li, Yaoting Gui · 2024 · Journal of Cancer
- Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer’s Disease: A Therapeutic ReviewManita Saini, Seema Rohilla, Rakesh Kumar · 2025 · Current Aging Science
- P7C3-A20 prevents whole brain radiotherapy-induced chronic hippocampal redox imbalance and neuropsychiatric impairment in miceEdwin Vázquez‐Rosa, Min‐Kyoo Shin, Kalyani Chaubey, Sarah Barker, Sofia G. Corella, Suwarna Chakraborty, Sunil Jamuna Tripathi, Youngmin Yu, Jiwon Hyung, Himanshu R. Dashora et al. · 2026 · Redox Biology
- Expression of ghrelin or growth hormone secretagogue receptor in the brain of postpartum stress miceJing-Wei Xing, Xin-Yun Tian, Man-Man Chen, Xiu-Hua Peng, Pengfei Gao · 2021 · Neuroreport
- Chemical Modulators of Protein Misfolding, Neurodegeneration and TauPierfausto Seneci · 2015 · Elsevier eBooks
- Peri-adolescent THC exposure does not lead to anxiety-like behavior in adult miceMatija Šestan-Peša, Marya Shanabrough, Tamás L. Horváth, Maria Consolata Miletta · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriersJeskanen, Heli, Heikkinen, Sami, Kervinen, Inka, Lehtisalo, Jenni, Ngandu, Tiia, Willman, Roosa-Maria, Rosa, Jessica, Hoffmann, Dorit, FinnGen, Leinonen, Ville et al. · 2026 · Alzheimer's Research & Therapy
- Depression and Anxiety After Radiation-Induced Brain Injury: A Review of Current Research ProgressFeng Yang, Rundong Liu, Xiaohong Peng, Na Luo, Min Fu, Wenjun Zhu, Qianxia Li, Guangyuan Hu · 2025 · Current Oncology
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male miceR. Stark, J. Zigman, Z. Andrews · 2025 · Journal of neuroendocrinology
- Roles of lactate and protein lactylation in neurogenesis and neurodegenerative diseaseXinyi Zhou, Jialin Han, Xiaolin Cui, Shuang Wu, Zhiming Lu, Shuai Zong · 2026 · Journal of Translational Medicine
- Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1Jan Zítko, Martin Doležal · 2015 · Expert Opinion on Therapeutic Patents
- Correction of neurogenesis in the adult brain: Selection of therapeutic targetsО. А. Гомазков · 2017 · Neurochemical Journal
- Study of the effects of the ghrelin-associated peptide obestatin on stress-related behaviorsJúlia Szakács · 2017
- Neuroprotective strategies for traumatic brain injuryTerry C. Yin · 2015
- Ghrelin Resistance: A Possible Mechanism Underlying Antidepressant-Induced Obesity?Jinhong Ma, Zhi-Gang Wang, Bin Zhu · 2016 · Journal of Child and Adolescent Psychopharmacology
- Leptin And Ghrelin – The New Old Players In Obesity And DepressionRositsa V. Sandeva, Stanislava M. Mihaylova, Gergana N. Sandeva · 2014 · Journal of Biomedical and Clinical Research
- Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent ModelsBrianne A. Kent · 2015 · Apollo (University of Cambridge)
- Antidépresseurs : aspects pharmacologiquesClaude Gauthier, Lama Souaiby, Marc Poirier, Jean‐Pierre Olié, Michael Krebs, Raphaël Gaillard B · 2016 · Time to knit
- The Neuroprotective Compound P7C3-A20 Promotes Neurogenesis and Improves Functional Outcomes After Focal Cerebral IschemiaZachary B. Loris · 2017
- The Behavioural, Neuroanatomical, and Molecular Effects of Chronic Social Stress on Mice That Lack Zinc Transporter 3 and Vesicular ZincBrendan B. McAllister · 2018 · Libraries and Cultural Resources (University of Calgary)
- The Role of Ghrelin and Ghrelin O-Acyltransferase in Obesity: Targets for TreatmentMartin K. Wellman · 2016
- CEE et agrobiologie: le grand tournantFrançois Roelants du Vivier · 1988 · Nature et progrès
- βCaMKII overexpression in the dentate gyrus does not result in depression- and anxiety-like behaviors in miceJuzhe Xi, Pengcheng Yin, Yu Jeong Kang, Gal Richter‐Levin, Kaiwen Zhang, Xiaohua Cao, Yao Liu, Yanhong Duan · 2022 · Stress and Brain
- Correlation of adult neurogenesis and cognitive performance in touchscreen tasks – assessing the novel small molecule OXS-N1 in miceJoel Melcop, Jun Yi Ong, Sabina Ciaghi, Myrto Keramopoulou, Alexej Schatz, York Winter, Francis G. Szele, Katharina Stumpenhorst · 2025 · Neuroscience
- The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriersH. Jeskanen, S. Heikkinen, I. Kervinen, J. Lehtisalo, T. Ngandu, R.-M. Willman, J. Rosa, D. Hoffmann, FinnGen, V. Leinonen et al. · 2025 · medRxiv
- Antidépresseurs : aspects pharmacologiquesMoussa A. Chalah, Raphaël Gaillard B · 2025 · Encyclopédie médico-chirurgicale. Psychiatrie
- Central liver-expressed antimicrobial peptide 2 induces anxiety- and depression-related behaviors and activates the hypothalamic-pituitary-adrenal axis in male miceMaximilian Tufvesson‐Alm, Elisabet Jerlhag · 2026 · Hormones and Behavior
- Rôle de la neurogenèse hippocampique adulte dans la résilience au stress : étude dans deux modèles murins de stress aigu et chroniqueBarbara Planchez · 2021 · theses.fr (ABES)
- Fasting ghrelin as mediator between obesity and depressive symptoms: a pre-registered studyKonrad Jakob Endres, Laurenz Lammer, Frauke Beyer, Daria E. A. Jensen, Dirk Alexander Wittekind, Margrit Löbner, Arno Villringer, Julia Sacher, A. Veronica Witte · 2026 · npj Mental Health Research
- Norisoboldine inhibits endoplasmic reticulum stress and alleviates depressive behaviors in CUMS mice by activating growth hormone secretagogue receptor type 1a in the hippocampusXinliu Wang, Shuxian Zang, Ziyun Ban, Yuxuan Zhang, Lingchen Hou, Xin Zhang (35492), Yuanyuan Wang, Depei Li, Feiyu An, Yuqi Liu et al. · 2026 · European Journal of Pharmacology
- For Weight Loss: Why Do GLP-1 Agonists Work, and How Can We Make Them Work Better?Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu · 2026 · Biology
- P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain DisordersYajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu · 2026 · CNS Neuroscience & Therapeutics
- Mechanistic link of obesity to depression and cognitive decline in Alzheimer’s diseaseKwabena Kusi‐Mensah, Nathan Jones, Humza Haroon, Marin Veldić, Doo‐Sup Choi · 2026 · Neuroscience & Biobehavioral Reviews
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- BindingDB Entry 50044309: Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.BindingDB · 2015 · UC San Diego