Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders

Alterations in glutamatergic transmission onto developing GABAergic systems, in particular onto parvalbumin-positive (Pv+) fast-spiking interneurons, have been proposed as underlying causes of several neurodevelopmental disorders, including schizophrenia and autism. Excitatory glutamatergic trans…