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A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Open access
Lefebvre, Celine, Rajbhandari, Presha, Alvarez, Mariano J, Bandaru, Pradeep, Lim, Wei Keat, Sato, Mai, Wang, Kai, Sumazin, Pavel, Kustagi, Manjunath, Bisikirska, Brygida C, Basso, Katia, Beltrao, Pedro, Krogan, Nevan, Gautier, Jean, Dalla‐Favera, Riccardo, Califano, Andrea·2010·Molecular Systems Biology

Abstract

Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre‐replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues.

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Metadata

Authors
Lefebvre, C., Rajbhandari, P., Alvarez, M. J., Bandaru, P., Lim, W. K., Sato, M., Wang, K., Sumazin, P., Kustagi, M., Bisikirska, B. C., Basso, K., Beltrao, P., Krogan, N., Gautier, J., Dalla‐Favera, R., & Califano, A.
Venue
Molecular Systems Biology
Published
2010-01
Volume
6
Issue
1
Pages
377-377
ISSN
1744-4292 (ISSN-L)
OpenAlex
W2105031411
Cited by
370
References
3
FWCI
7.09
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. https://app.cochat.ai/papers/10.1038/msb.2010.31
The paper
Lefebvre, C., Rajbhandari, P., Alvarez, M. J., Bandaru, P., Lim, W. K., Sato, M., Wang, K., Sumazin, P., Kustagi, M., Bisikirska, B. C., Basso, K., Beltrao, P., Krogan, N., Gautier, J., Dalla‐Favera, R., & Califano, A. (2010). A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Molecular Systems Biology. https://doi.org/10.1038/msb.2010.31

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.