The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Emergent cooperation in microbial metabolism
Open accessAbstract
Mixed microbial communities exhibit emergent biochemical properties not found in clonal monocultures. We report a new type of synthetic genetic interaction, synthetic mutualism in trans (SMIT), in which certain pairs of auxotrophic Escherichia coli mutants complement one another's growth by cross‐feeding essential metabolites. We find significant metabolic synergy in 17% of 1035 such pairs tested, with SMIT partners identified throughout the metabolic network. Cooperative phenotypes show more growth on average by aiding the proliferation of their conjugate partner, thereby expanding the source of their own essential metabolites. We construct a quantitative, predictive, framework for describing SMIT interactions as governed by stoichiometric models of the metabolic networks of the interacting strains.
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Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Five Rules for the Evolution of Cooperation
Nowak, M. A. (2006) · Science · doi:10.1126/science.1133755 · Cited by 5,894
Social semantics: altruism, cooperation, mutualism, strong reciprocity and group selection.
WEST, S. A., GRIFFIN, A. S., & GARDNER, A. (2007) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2006.01258.x · Cited by 1,889
Modular epistasis in yeast metabolism
Segrè, D., DeLuna, A., Church, G. M., & Kishony, R. (2005) · Nature Genetics · doi:10.1038/ng1489 · Cited by 575
Cited by
Greenblum, S., Turnbaugh, P. J., & Borenstein, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116053109 · Cited by 821
Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods
Lewis, N. E., Nagarajan, H., & Palsson, B. O. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2737 · Cited by 779
Marine crude-oil biodegradation: a central role for interspecies interactions
McGenity, T. J., Folwell, B. D., McKew, B. A., & Sanni, G. O. (2012) · Aquatic Biosystems · doi:10.1186/2046-9063-8-10 · Cited by 430
Deep Sequencing of the Oral Microbiome Reveals Signatures of Periodontal Disease
Liu, B., Faller, L. L., Klitgord, N., Mazumdar, V., Ghodsi, M., Sommer, D. D., Gibbons, T. R., Treangen, T. J., Chang, Y.-C., Li, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037919 · Cited by 411
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community
Blasche, S., Kim, Y., Mars, R. A. T., Machado, D., Maansson, M., Kafkia, E., Milanese, A., Zeller, G., Teusink, B., Nielsen, J., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-020-00816-5 · Cited by 328
Metadata
- Authors
- Wintermute, E. H., & Silver, P. A.
- Venue
- Molecular Systems Biology
- Published
- 2010-01
- Volume
- 6
- Issue
- 1
- Pages
- 407-407
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2142026735
- Cited by
- 344
- References
- 4
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- gold
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