Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases

Li, Lijing, Krymskaya, Ludmila, Wang, Jianbin, Henley, Jill, Rao, Anitha, Cao, Lan-Feng, Tran, Chy-Anh, Torres-Coronado, Monica, Gardner, Agnes, Gonzalez, Nancy, Kim, Kenneth, Liu, Pei-Qi, Hofer, Ursula, Lopez, Evan, Gregory, Philip D, Liu, Qing, Holmes, Michael C, Cannon, Paula M, Zaia, John A, DiGiusto, David L·2013·Molecular Therapy
DOI 10.1038/mt.2013.65

Cited by (181)

Items 101–181 of 181

  1. Genome Engineering in Human Cells
    Minjung Song, Young‐Hoon Kim, Jin‐Soo Kim, Seokjoong Kim · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
  2. Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1
    Wannisa Khamaikawin, Saki Shimizu, Masakazu Kamata, Ruth Cortado, Yu‐Jin Jung, Jennifer Lam, Jing Wen, Patrick Kim, Yiming Xie, Sanggu Kim et al. · 2017 · Molecular Therapy — Methods & Clinical Development
  3. HIV cure strategies: which ones are appropriate for Africa?
    Christopher Zaab-Yen Abana, Helena Lamptey, Evelyn Yayra Bonney, George B. Kyei · 2022 · Cellular and Molecular Life Sciences
  4. TALENs-mediated homozygous CCR5Δ32 mutations endow CD4+ U87 cells with resistance against HIV‑1 infection
    Ai Qing Yu, Yan Ding, Zhi Yong Lu, Hao Yan, Zhi Teng, Shi Yan, Dong Li, Yi Zeng · 2017 · Molecular Medicine Reports
  5. CRISPR/dCas9‐mediated transposition with specificity and efficiency of site‐directed genomic insertions
    Lena Goshayeshi, Sara Yousefi Taemeh, Nima Dehdilani, M Nasiri, Mohammad Mahdi Ghahramani Seno, Hesam Dehghani · 2021 · The FASEB Journal
  6. Progress toward curing HIV infection with hematopoietic cell transplantation
    Lawrence D. Petz, John Burnett, Haitang Li, Shirley Li, Richard Tonai, Milena Bakalinskaya, Elizabeth J. Shpall, Sue K. Armitage, Joanne Kurtzberg, Donna M. Regan et al. · 2015 · Stem Cells and Cloning Advances and Applications
  7. Fight fire with fire: Gene therapy strategies to cure HIV
    Jonas Huyghe, Sips Magdalena, L. Vandekerckhove · 2017 · Expert Review of Anti-Infective Therapy
  8. A rapidly evolving revolution in stem cell biology and medicine
    Alan O. Trounson · 2013 · Reproductive BioMedicine Online
  9. Transplantation in HIV-infected subjects: is cure possible?
    John A. Zaia, Stephen J. Forman · 2013 · Hematology
  10. Genome editing: a robust technology for human stem cells
    Arun Pandian Chandrasekaran, Minjung Song, Suresh Ramakrishna · 2017 · Cellular and Molecular Life Sciences
  11. Gene Therapy Strategies to Block HIV-1 Replication by RNA Interference
    Elena Herrera-Carrillo, Ben Berkhout · 2015 · Advances in experimental medicine and biology
  12. Designer Nucleases: Gene-Editing Therapies using CCR5 as an Emerging Target in HIV
    Maria João Almeida, Ana Miguel Matos · 2019 · Current HIV Research
  13. Genome Editing in Stem Cells for Disease Therapeutics
    Minjung Song, Suresh Ramakrishna · 2018 · Molecular Biotechnology
  14. Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application
    Kateryna Kratzer, Landon J. Getz, Thibaut Peterlini, Jean‐Yves Masson, Graham Dellaire · 2021 · Human Genetics
  15. Progress in and Prospects of Genome Editing Tools for Human Disease Model Development and Therapeutic Applications
    Hong Thi Lam Phan, Kyoungmi Kim, Ho Lee, Je Kyung Seong · 2023 · Genes
  16. Mechanistic Models Predict Efficacy of CCR5‐Deficient Stem Cell Transplants in HIV Patient Populations
    Iraj Hosseini, Feilim Mac Gabhann · 2016 · CPT Pharmacometrics & Systems Pharmacology
  17. Engineering hematopoietic stem cells toward a functional cure of human immunodeficiency virus infection
    Jianbin Wang, Michael C. Holmes · 2016 · Cytotherapy
  18. Gene therapies in clinical trials
    Konstantinos I. Papadopoulos, Phanphen Wattanaarsakit, Weerapong Prasongchean, Ravin Narain · 2016 · Elsevier eBooks
  19. Generation of human induced pluripotent stem cells from individuals with a homozygous CCR5Δ32 mutation
    Guibin Chen, Hui Zi Jin, Zhen Yu, Yangtengyu Liu, Zhongwen Li, Keron Navarengom, Robin Schwartzbeck, Natalia I. Dmitrieva, Cornelia Diana Cudrici, Elisa A. Ferrante et al. · 2019 · Stem Cell Research
  20. Clinical Applications of Genome Editing to HIV Cure
    Cathy X. Wang, Paula M. Cannon · 2016 · AIDS Patient Care and STDs
  21. Prevalence of CCR5delta32 in Northeastern Iran
    Amir Tajbakhsh, Mostafa Fazeli, Mehdi Rezaee, Faezeh Ghasemi, Mastoureh Momen Heravi, Aida Gholoobi, Zahra Meshkat · 2019 · BMC Medical Genetics
  22. The Strategies and Challenges of CCR5 Gene Editing in Hematopoietic Stem and Progenitor Cells for the Treatment of HIV
    Karthik V. Karuppusamy, Prathibha Babu, Saravanabhavan Thangavel · 2021 · Stem Cell Reviews and Reports
  23. Stem Cell Gene Therapy for HIV: Strategies to Inhibit Viral Entry and Replication
    David L. DiGiusto · 2015 · Current HIV/AIDS Reports
  24. Mutations in chemokine receptors and AIDS
    Jing Kou, Yi‐Qun Kuang · 2018 · Progress in molecular biology and translational science
  25. Hematopoietic stem and progenitors cells gene editing: Beyond blood disorders
    Valentina Buffa, José Roberto Alvarez Vargas, Anne H. M. Galy, Simone Spinozzi, Céline J. Rocca · 2023 · Frontiers in Genome Editing
  26. Conditional Cytotoxic Anti-HIV Gene Therapy for Selectable Cell Modification
    Himanshu Garg, Anjali Joshi · 2016 · Human Gene Therapy
  27. Stem Cell Research and Social Justice: Aligning Scientific Progress with Social Need
    Brooke Ellison · 2016 · Current Stem Cell Reports
  28. Hematopoietic Stem and Immune Cells in Chronic HIV Infection
    Jielin Zhang, Clyde S. Crumpacker · 2015 · Stem Cells International
  29. Genome Editing by Targeted Chromosomal Mutagenesis
    Dana Carroll · 2014 · Methods in molecular biology
  30. Targeted genome correction by a single adenoviral vector simultaneously carrying an inducible zinc finger nuclease and a donor template
    Weifeng Zhang, Hao Chen, Xiaojing Zheng, Dongyang Wang, Haiyan Ji, Haibin Xia, Qinwen Mao · 2014 · Journal of Biotechnology
  31. The therapeutic potential of genome editing for β-thalassemia
    Astrid Glaser, Bradley McColl, Jim Vadolas · 2015 · F1000Research
  32. Gene editing for corneal disease management
    Sudhanshu P. Raikwar, Apoorva S Raikwar, Shyam Sunder Chaurasia, Rajiv R. Mohan · 2016 · World Journal of Translational Medicine
  33. Oxidative Stress, Redox Regulation and Elite Controllers of HIV Infection: Towards a Functional Cure
    Bartholomew Okechukwu Ibeh · 2015 · InTech eBooks
  34. Prospects of viral vector-mediated delivery of sequences encoding anti-HBV designer endonucleases
    Ridhwaanah Jacobs, Prashika Singh, Tiffany S. Smith, Patrick B. Arbuthnot, Mohube Betty Maepa · 2022 · Gene Therapy
  35. Can Genome Engineering be used to Target Cancer-Associated Enhancers?
    Matthew Grimmer, Peggy Farnham · 2014 · Epigenomics
  36. Application of induced pluripotent stem cell technology for the investigation of hematological disorders
    Hamid Dolatshad, Dharamveer Tatwavedi, Doaa Ahmed, Jana F. Tegethoff, Jacqueline Boultwood, Andrea Pellagatti · 2018 · Advances in Biological Regulation
  37. Generation of HIV-1-infected patients’ gene-edited induced pluripotent stem cells using feeder-free culture conditions
    Lin Ye, Jiaming Wang, Fernando Teque, Fei Xie, Yuting Tan, Yuet Wai Kan, Jay A. Levy · 2020 · AIDS
  38. Transcription factors and their roles in phosphorus stress tolerance in crop plants
    Anuj Kumar, Vijay Gahlaut, M. Nagaraju · 2020 · Elsevier eBooks
  39. Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection
    Tetsuo Tsukamoto · 2019 · Pharmaceutics
  40. Genetic Modulation Therapy Through Stem Cell Transplantation for Human Immunodeficiency Virus 1 Infection
    Varshil Mehta, Divya Chandramohan, Shivika Agarwal · 2017 · Cureus
  41. Efficient ZFN-Mediated Stop Codon Integration into the CCR5 Locus in Hematopoietic Stem Cells: A Possible Source for Intrabone Marrow Cell Transplantation
    Supreecha Chattong, Kamontip Chaikomon, Theerasak Chaiya, Thitirat Tangkosakul, Nattawan Palavutitotai, Thitinun Anusornvongchai, Krissanapong Manotham · 2018 · AIDS Research and Human Retroviruses
  42. The Development and Use of Zinc-Finger Nucleases
    Dana Carroll · 2016 · Advances in experimental medicine and biology
  43. Optimizing Delivery and Expression of Designer Nucleases for Genome Engineering
    Marinee Chuah, Thierry VandenDriessche · 2013 · Human Gene Therapy Methods
  44. In pursuit of an HIV cure: from stem cell transplants to gene therapies
    Jennifer Clees, Maya Basic, Pedro E. Cruz, Servio H. Ramirez, Allison Michelle Andrews · 2025 · Frontiers in Genome Editing
  45. Stem cell transplantation in the context of HIV – how can we cure HIV infection?
    Gerhard Bauer, Joseph S. Anderson · 2013 · Expert Review of Clinical Immunology
  46. Cell therapies for treatment of human immunodeficiency virus infection
    Daniele Focosi, Fabrizio Maggi, Luca Ceccherini‐Nelli, Mauro Pistello · 2015 · Reviews in Medical Virology
  47. Enhanced Genetic Modification of Adult Growth Factor Mobilized Peripheral Blood Hematopoietic Stem and Progenitor Cells With Rapamycin
    Lijing Li, Mónica Torres-Coronado, Angel Gu, Anitha Rao, Agnes M. Gardner, Elizabeth W. Epps, Nancy González, Chy-Anh Tran, Xiwei Wu, Jinhui Wang et al. · 2014 · Stem Cells Translational Medicine
  48. Global scenario of HIV/AIDS: Declining trend and moving toward cure
    Ramalingam Sekar, Manoharan Mythreyee · 2016 · Indian Journal of Public Health
  49. Viral Vectors for Delivery of Antiviral Sequences
    Patrick B. Arbuthnot · 2015 · Elsevier eBooks
  50. Perspectivas da terapia gênica
    Eugênia Costanzi-Strauss, Bryan Eric Strauss · 2015 · Revista de Medicina
  51. New human chromosomal safe harbor sites for genome engineering with CRISPR/Cas9, TAL effector and homing endonucleases
    Stefan Pellenz, Michael Phelps, Weiliang Tang, Blake T. Hovde, Ryan B. Sinit, Wenqing Fu, Hui Li, Eleanor Y. Chen, Raymond J. Monnat · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells
    Rahul Sampath, Nathan W. Cummins, Sekar Natesampillai, Gary D. Bren, Thomas D.Y. Chung, Jason V. Baker, Keith Henry, Amélie Pagliuzza, Andrew D. Badley · 2017 · PLoS ONE
  53. Advancing towards HIV-1 remission: Insights and innovations in stem cell therapies
    Aditi Chatterjee, Aerielle E. Matsangos, Olga Latinovic, Alonso Heredia, Giovannino Silvestri · 2024 · Archives of Stem Cell and Therapy
  54. Development of 2LTRZFP-expressing induced pluripotent stem cells as a potential anti-HIV-1 gene therapy against viral integration
    Kritayaporn Saiprayong, Koollawat Chupradit, Pasut Sasithong, Siriwal Suwanpitak, Saitong Muneekaew, Nontaphat Thongsin, Jakkrapatra Srisantitham, Methichit Wattanapanitch · 2025 · Journal of Leukocyte Biology
  55. From bench to bedside: stem cell therapy as a transformative approach against HIV
    Ankit Kumar Bharti S, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Babu Gajendran, Rahul Vashishth, Sabina Evan Prince · 2026 · Molecular Biology Reports
  56. Zinc Finger Nuclease Editing of Hematopoietic Stem Cells as an Anti-HIV Therapy
    Nathalia G. Holt, Colin M. Exline, Orla Mulhern, Ursula Hofer, Kathleen A. Burke, Jill E. Oldenburg, Paula M. Cannon · 2014 · Springer eBooks
  57. Cellular Engineering and Disease Modeling with Gene-Editing Nucleases
    Mark J. Osborn, Jakub Tolar · 2016 · Advances in experimental medicine and biology
  58. Gene Editing in Adult Hematopoietic Stem Cells
    Sergio López-Manzaneda, Sara Fañanas-Baquero, Virginia Nieto-Romero, Francisco J Roman‐Rodriguez, María Fernández-García, María José Pino-Barrio, Fátima Rodríguez-Fornés, Begoña Díez, Marı́a Garcı́a-Bravo, Susana Navarro et al. · 2016 · InTech eBooks
  59. Gulo gene locus, a new gene editing locus for mammalian cells
    Toshiyuki Habu, Honoka Ishikawa, Jiyeong Kim · 2022 · Biotechnology Journal
  60. HIV Biology: Detailed Insight into Virion Structural Organization and Its Pathogenesis
    Deeksha Agrawal, Kailash Chand, L. Preethi, Prudhvi Lal Bhukya, Muneesh Kumar Barman · 2024 · Springer eBooks
  61. Bringing back the help: autologous bone marrow infusion restores CD4+ T cells in AIDS patients with chronic liver disease
    Arnold B. Rabson · 2013 · Cell Death and Disease
  62. Second Generation Genome Editing Technologies in Drug Discovery
    Thomas Malcolm, David A. Mitchell, Niraj Muni · 2020 · Elsevier eBooks
  63. Using Engineered Nucleases to Create HIV-Resistant Cells
    George N. Llewellyn, Colin M. Exline, Nathalia G. Holt, Paula M. Cannon · 2016 · Advances in experimental medicine and biology
  64. Hematopoietic stem cell gene therapy: progress and challenges
    Xiao‐Bing Zhang, Tao Cheng, Jianping Zhang · 2017 · Scientia Sinica Vitae
  65. Stem Cell Engineering Developments And Advances In Providing HIV Immunity
    Joseph DeSimone, Vincent S. Gallicchio · 2021 · Journal Of Stem Cell Research
  66. Hematopoietic Cell Therapy for Human Immunodeficiency Virus Infection
    Amrita Y. Krishnan, Joseph Alvarnas, John J. Rossi, John A. Zaia · 2015
  67. Vesiculovirus G protein-based stable cell lines for continuous lentiviral vector production
    Maha Tijani · 2018 · UCL Discovery (University College London)
  68. Resistencia genética a la infección por VIH-1 mediada por polimorfismos genéticos del CR2
    Facultad de Ciencias Experimentales · 2014
  69. Gene Correction Technology and Its Impact on Viral Research and Therapy
    Guan Huei Lee, Myo Myint Aung · 2016 · InTech eBooks
  70. Gene Therapy for HIV-1 Infection
    Patrick B. Arbuthnot · 2015 · Elsevier eBooks
  71. Progress of genome editing approaches towards gene therapy
    Haiyan Ji, Huanzhang Zhu · 2015
  72. Gene therapy in the treatment of retinal dystrophies
    Luz Ángela Hernández, Ginna Tatiana Tachack Abril, José Luis Henao Calderón · 2018 · Ciencia y Tecnología para la Salud Visual y Ocular
  73. The role of Bryostatin and PMA (Phorbole Myristate Acetate) in enhancing ZFN’s Anti-HIV effects
    Hanaa A. Alahmad, sawsan madi, Adnan M. Ikhtiar · 2021 · Research Journal of Pharmacy and Technology
  74. HIV/Aids Treatment by Stem Cell Transplantation: A Review
    Kalpesh Pundlik Mahajan · 2021
  75. Defining interactions between assembling HIV-1 virions and host cell plasma membrane proteins
    Jonathan R. Grover · 2013 · Deep Blue (University of Michigan)
  76. Genome‐Editing Applications in Stem Cell Engineering and Regenerative Medicine
    Pragya Gupta, Shashank Jaitly, Priya Thakur, Sangam Giri Goswami, Nupur Bhargava, Sivaprakash Ramalingam · 2022 · Wiley eBooks
  77. Therapeutic Gene Editing
    Chen Zhang, Haotian Li, Keshore R. Bidasee, Howard Eliot Gendelman, Prasanta Kumar Dash · 2024 · Springer eBooks
  78. Molecular Functions and Potential Utilization of Zinc Finger Proteins in Protozoan Parasites
    Benard Aswani Ouna · 2025
  79. Etude du développement lymphoïde T à partir des progéniteurs hématopoïétiques CD34+ chez les patients infectés par le VIH-1 et traités par une thérapie antirétrovirale
    Inna Menkova · 2016
  80. Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology
    Hong‐Ru Chen, Nicole P. Kadzioch, Madeleine Gapp, Hsiu-Hui Yang, Adrian Ruhle, Javier M. Villamizar, Thimo Fuchs, Niklas Arndt Schmacke, Veit Hornung, Roberto F. Speck et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  81. Host Barriers to In Vivo HSC Gene Therapy with Helper-Dependent Adenovirus Vectors
    Anna Kate Anderson, André Lieber, Chang Li · 2026 · Viruses