Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo

Cesana, Daniela, Ranzani, Marco, Volpin, Monica, Bartholomae, Cynthia, Duros, Caroline, Artus, Alexandre, Merella, Stefania, Benedicenti, Fabrizio +11 more·2014·Molecular Therapy

Cited by (189)

Items 101–189 of 189

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  4. Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
    Singh, Swati, Khan, Iram, Khim, Socheath, Seymour, Brenda, Sommer, Karen, Wielgosz, Matthew, Norgaard, Zachary, Kiem, Hans-Peter, Adair, Jennifer, Liggitt, Denny et al. · 2017 · Molecular Therapy - Methods & Clinical Development
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  6. Non-clinical safety assessment of novel drug modalities: Genome safety perspectives on viral-, nuclease- and nucleotide-based gene therapies
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  7. The Current Landscape of Secondary Malignancies after CAR T-Cell Therapies: How Could Malignancies Be Prevented?
    Stella Bouziana, Dimitrios Bouzianas · 2024 · International Journal of Molecular Sciences
  8. Insulated Foamy Viral Vectors
    D. Browning, Casey Collins, Jonah D. Hocum, David J. Leap, Dustin T. Rae, G. Trobridge · 2016 · Human Gene Therapy
  9. Viral vectors as a promising nanotherapeutic approach against neurodegenerative disorders
    Vaibhavi Srivastava, Ajit Singh, Gaurav Kumar Jain, Farhan Jalees Ahmad, Rahul Shukla, Prashant Kesharwani · 2021 · Process Biochemistry
  10. Evidence for the in vivo safety of insulated foamy viral vectors
    Diana L. Browning, Elizabeth M. Everson, David J. Leap, Jonah D. Hocum, H Wang, George Stamatoyannopoulos, G D Trobridge · 2016 · Gene Therapy
  11. The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes
    Sabina Sánchez-Hernández, Alejandra Gutiérrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierréz, María Tristán‐Manzano, Sandra Rodríguez, Laura Sánchez, Jose Luis Garcia-Perez, Jesús Chato‐Astrain, Ricardo Fernández‐Valadés et al. · 2018 · Molecular Therapy — Nucleic Acids
  12. In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy
    Yingyu Chen, Jocelyn A. Schroeder, Chunyan Gao, Jing Li, Jianda Hu, Qizhen Shi · 2020 · Journal of Cellular Physiology
  13. Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
    Idalia M. Yabe, Lauren L. Truitt, Diego A. Espinoza, Chuanfeng Wu, Samson Koelle, Sandhya Ramanathan Panch, Marcus Alexandre Finzi Corat, Thomas Winkler, Kyung–Rok Yu, So Gun Hong et al. · 2018 · Molecular Therapy — Methods & Clinical Development
  14. Risk and Benefit Assessment of Gene Therapy with Lentiviral Vectors and Hematopoietic Stem Cells: The Skysona Case
    Pilar Puig-Serra, Ana Hinckley-Boned, María Tristán‐Manzano, Paula Rı́o, Raúl Torres-Ruiz, Sandra Rodríguez, Francisco Martı́n · 2025 · Human Gene Therapy
  15. Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization
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  16. InsB9-23 Gene Transfer to Hepatocyte-Based Combined Therapy Abrogates Recurrence of Type 1 Diabetes After Islet Transplantation
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  19. Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models
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  20. Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation
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  21. Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side
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  23. Quantum pBac : An effective, high‐capacity piggyBac ‐ based gene integration vector system for unlocking gene therapy potential
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  26. Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection
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  27. Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article
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  28. Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy
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  29. Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head
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  30. Mutagenesis and Carcinogenesis Risk Evaluation for AAV and Lentiviral Gene Therapies
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  31. Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology
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  32. Success Stories and Challenges Ahead in Hematopoietic Stem Cell Gene Therapy: Hemoglobinopathies as Disease Models
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  33. Tightly regulated ‘all-in-one’ lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy
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  34. Multiple Genes Surrounding Bcl-x L , a Common Retroviral Insertion Site, Can Influence Hematopoiesis Individually or in Concert
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  39. Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells
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  40. Editing T cell repertoire by thymic epithelial cell-directed gene transfer abrogates risk of type 1 diabetes development
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