The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Toxicity and management in CAR T-cell therapy
Open accessAbstract
T cells can be genetically modified to target tumors through the expression of a chimeric antigen receptor (CAR). Most notably, CAR T cells have demonstrated clinical efficacy in hematologic malignancies with more modest responses when targeting solid tumors. However, CAR T cells also have the capacity to elicit expected and unexpected toxicities including: cytokine release syndrome, neurologic toxicity, "on target/off tumor" recognition, and anaphylaxis. Theoretical toxicities including clonal expansion secondary to insertional oncogenesis, graft versus host disease, and off-target antigen recognition have not been clinically evident. Abrogating toxicity has become a critical step in the successful application of this emerging technology. To this end, we review the reported and theoretical toxicities of CAR T cells and their management.
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Cites
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Cited by
Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
Neelapu, S. S., Tummala, S., Kebriaei, P., Wierda, W., Gutierrez, C., Locke, F. L., Komanduri, K. V., Lin, Y., Jain, N., Daver, N., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.148 · Cited by 2,438
CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade
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Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
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Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
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IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Tahtinen, S., Tong, A.-J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01160-y · Cited by 535
Metadata
- Authors
- Bonifant, C. L., Jackson, H. J., Brentjens, R. J., & Curran, K. J.
- Venue
- Molecular Therapy - Oncolytics
- Publisher
- Elsevier BV
- Published
- 2016
- Volume
- 3
- Pages
- 16011
- ISSN
- 2372-7705 (ISSN-L)
- OpenAlex
- W2335984750
- Cited by
- 885
- References
- 17
- FWCI
- 40.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bonifant, C. L., Jackson, H. J., Brentjens, R. J., & Curran, K. J. (2016). Toxicity and management in CAR T-cell therapy. Molecular Therapy - Oncolytics. https://doi.org/10.1038/mto.2016.11
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
