Biotech giant publishes failures to confirm high-profile science
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Bayer Healthcare reported that they were only able to verify 25% of preclinical research.
“Bayer Healthcare released a similar report disclosing that they were only able to verify 25% of preclinical research [38,39].”
From The history, landscape, and outlook of human cell line authentication and security (2024) · cites this paper as [38]
The IRREPRODUCIBLE HISTORY section reports that Amgen could not reproduce findings in 47 of 53 cancer papers; it does not report a Bayer Healthcare result. Searches for Bayer, 25%, and a quarter of preclinical findings found no passage addressing the claimed figure. (LLM, conf=0.76)
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Raise standards for preclinical cancer research
Begley, C. G., & Ellis, L. M. (2012) · Nature · doi:10.1038/483531a · Cited by 2,979 · see citing works
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works
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Tackett, J. L., Lilienfeld, S. O., Patrick, C. J., Johnson, S. L., Krueger, R. F., Miller, J. D., Oltmanns, T. F., & Shrout, P. E. (2017) · Perspectives on Psychological Science · doi:10.1177/1745691617690042 · Cited by 251 · see citing works
Prediction of robust scientific facts from literature
Belikov, A. V., Rzhetsky, A., & Evans, J. (2022) · Nature Machine Intelligence · doi:10.1038/s42256-022-00474-8 · Cited by 30 · see citing works
Church, K. W., & Kordoni, V. (2022) · Natural Language Engineering · doi:10.1017/s1351324922000043 · Cited by 28 · see citing works
The history, landscape, and outlook of human cell line authentication and security
Harbut, E., Makris, Y., Pertsemlidis, A., & Bleris, L. (2024) · SLAS Discovery · doi:10.1016/j.slasd.2024.100194 · Cited by 8 · see citing works
- Authors
- Baker, M.
- Corresponding author
- Baker, Monya
- Venue
- Nature
- Published
- 2016-02-04
- Volume
- 530
- Issue
- 7589
- Pages
- 141-141
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2259670296
- Cited by
- 47
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 8
- Type
- other
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmaceutical industry and healthcare
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- Amgen, reproducibility, replication failure, research integrity, scholarly publishing, online forums, pharmaceutical industry research
- MeSH terms
- Biotechnology, Drug Industry, United States, Reproducibility of Results, Uncertainty, Biomedical Research, Open Access Publishing
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