The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
The inflammatory reflex
Abstract
Inflammation is a local, protective response to microbial invasion or injury. It must be fine-tuned and regulated precisely, because deficiencies or excesses of the inflammatory response cause morbidity and shorten lifespan. The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded our understanding of how the nervous system modulates immune responses. The nervous system reflexively regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. The opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
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In the citing paper
“Similarly, early life stressful experiences might reduce inhibitory cholinergic neurotransmission (25), favoring inflammation persistence (26).”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [26]
In the citing paper
“For example, in response to pathogens and other injurious stimuli, tumor-necrosis factor-alpha (TNF-α), a cytokine, is produced by activated macrophages, dendritic cells, and other cells in the mucosa (3, 65).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [65]
In the citing paper
“In addition, the autonomic nervous system regulates peripheral cytokine production. Parasympathetic nerves directly affect the immune system, while sympathetic nerves affect the immune system through NA secretion from the peripheral sympathetic ganglia. The vagus nucleus, which is located in the pons, inhibits immune functions and cytokine production through the secretion of Ach from the vagus ner”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [8]
In the citing paper
“The efferent arm of the inflammatory reflex, now termed the cholinergic antiinflammatory pathway (14), is a highly robust mechanism for cytokine control.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [14]
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citationShock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“Inflammation mediated by TNF Tumour-necrosis factor (TNF), a cytokine with a relative molecular mass of 17,000 ( M r 17K), is produced by activated macrophages in response to pathogens and other injurious stimuli, and is a necessary and sufficient mediator of local and systemic inflammatio”
BackgroundSelf-citationRole of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citationFunctional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Deactivation of macrophages by transforming growth factor-β
Tsunawaki, S., Sporn, M. B., Ding, A. H., & Nathan, C. (1988) · Nature · doi:10.1038/334260a0 · Cited by 862
A molecular basis for bidirectional communication between the immune and neuroendocrine systems.
Blalock, J. E. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.1.1 · Cited by 837
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 755
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
Watkins, L. R., & Maier, S. F. (2002) · Physiological Reviews · doi:10.1152/physrev.00011.2002 · Cited by 733
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
Ulloa, L., Ochani, M., Yang, H., Tanovic, M., Halperin, D. M., Yang, R., Czura, C. J., Fink, M. P., & Tracey, K. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192222999 · Cited by 585
Self-citationEnhanced recognition memory following vagus nerve stimulation in human subjects
Clark, K., Naritoku, D., Smith, D. C., Browning, R., & Jensen, R. A. (1999) · Nature Neuroscience · doi:10.1038/4600 · Cited by 575
The immune system as a sensory organ.
Blalock, J. E. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.3.1067 · Cited by 551
Pharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
Self-citationVagal immune-to-brain communication: a visceral chemosensory pathway
Goehler, L. E., Gaykema, R. P. A., Hansen, M. K., Anderson, K., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00219-8 · Cited by 525
Watkins, L. R., Goehler, L. E., Relton, J. K., Tartaglia, N., Silbert, L., Martin, D., & Maier, S. F. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11105-r · Cited by 516
van der Poll, T., Coyle, S. M., Barbosa, K., Braxton, C. C., & Lowry, S. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118469 · Cited by 514
Transdermal Nicotine for Active Ulcerative Colitis
Pullan, R. D., Rhodes, J., Ganesh, S., Mani, V., Morris, J. S., Williams, G. T., Newcombe, R. G., Russell, M., Feyerabend, C., Thomas, G., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403243301202 · Cited by 505 · cited 1×
“A precedent for this approach has been already achieved in the clinic, because nicotine administration is significantly efficacious in reducing the severity of ulcerative coliti”
BackgroundHMGB1 as a Late Mediator of Lethal Systemic Inflammation
Wang, H., Yang, H., Czura, C. J., Sama, A. E., & Tracey, K. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2106117 · Cited by 490
Self-citationTracey, K. J., Vlassara, H., & Cerami, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92394-5 · Cited by 487
Self-citationCatecholamine Influences and Sympathetic Neural Modulation of Immune Responsiveness
Madden, K. S., Sanders, V. M., & Felten, D. L. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.002221 · Cited by 441
Woiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schöning, B., Glöckner, F., Lanksch, W., Volk, H., & Döcke, W. (1998) · Nature Medicine · doi:10.1038/nm0798-808 · Cited by 435
Wessler, I. K., Kirkpatrick, C. J., & Racké, K. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00085-5 · Cited by 415
Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J., & Rennick, D. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.241 · Cited by 402
Vagus nerve stimulation, side effects, and long-term safety
Ben-Menachem, E. (2001) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200109000-00005 · Cited by 400
Experimental basis for neural-immune interactions
Madden, K. S., & Felten, D. L. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.77 · Cited by 385
Extraneuronal cholinergic system in lymphocytes
Kawashima, K. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00071-6 · Cited by 384
Hommes, D. W., van den Blink, B., Plasse, T. F., Bartelsman, J. F. W. M., Xu, C., Macpherson, B., Tytgat, G. N. J., Peppelenbosch, M. P., & van Deventer, S. J. H. (2002) · Gastroenterology · doi:10.1053/gast.2002.30770 · Cited by 378
Besedovsky, H. O., Sorkin, E., Felix, D., & Haas, H. (1977) · European Journal of Immunology · doi:10.1002/eji.1830070516 · Cited by 364
Goehler, L. E., Relton, J. K., Dripps, D. J., Kiechle, R., Tartaglia, N. R., Maier, S. F., & Watkins, L. R. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00020-8 · Cited by 326
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
Borovikova, L. V., Ivanova, S., Nardi, D., Zhang, M., Yang, H., Ombrellino, M., & Tracey, K. J. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00233-2 · Cited by 322
Self-citationAdrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
Bertini, R., Bianchi, M., & Ghezzi, P. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.5.1708 · Cited by 291
Implications of immune-to-brain communication for sickness and pain
Watkins, L. R., & Maier, S. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7710 · Cited by 250
Sato, K. Z., Fujii, T., Watanabe, Y., Yamada, S., Ando, T., Fujimoto, K., & Kawashima, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00259-1 · Cited by 238
Breder, C. D., Hazuka, C., Ghayur, T., Klug, C., Huginin, M., Yasuda, K., Teng, M., & Saper, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11393 · Cited by 226
Lantz, M., Gullberg, U., Nilsson, E., & Olsson, I. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114853 · Cited by 221
The Stress Response and Immune Function: Clinical Implications: The 1999 Novera H. Spector Lecture
Chrousos, G. P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05371.x · Cited by 197
The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose
Hansen, M. K., O'Connor, K. A., Goehler, L. E., Watkins, L. R., & Maier, S. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.4.r929 · Cited by 169
Felten, D. L., & Maida, M. E. (2002) · Elsevier eBooks · doi:10.1016/b0-12-227210-2/00292-2 · Cited by 148
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.
Bianchi, M., Bloom, O., Raabe, T. D., Cohen, P. S., Chesney, J. A., Sherry, B. A., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.927 · Cited by 127
Self-citationAcetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity
Sato, E., Koyama, S., Okubo, Y., Kubo, K., & Sekiguchi, M. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.6.l970 · Cited by 121
Bianchi, M., Ulrich, P. C., Bloom, O., Meistrell, M. E., Zimmerman, G. A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B. A., et al. (1995) · Molecular Medicine · doi:10.1007/bf03401550 · Cited by 116
Self-citationInhibition of Immediate-type Hypersensitivity Response by Direct Suggestion Under Hypnosis
Black, S. (1963) · BMJ · doi:10.1136/bmj.1.5335.925 · Cited by 113
Blalock, J. E. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb23112.x · Cited by 102
Amiodarone Inhibits Production of Tumor Necrosis Factor-α by Human Mononuclear Cells
Matsumori, A., Ono, K., Nishio, R., Nose, Y., & Sasayama, S. (1997) · Circulation · doi:10.1161/01.cir.96.5.1386 · Cited by 99
Novak, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc988 · Cited by 97
Johansson, A. C. M., Hansson, A.-S., Nandakumar, K. S., Bäcklund, J., & Holmdahl, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3505 · Cited by 96
Spermine inhibition of monocyte activation and inflammation
Zhang, M., Borovikova, L. V., Wang, H., Metz, C., & Tracey, K. J. (1999) · Molecular Medicine · doi:10.1007/bf03402072 · Cited by 92
Self-citationAcupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects.
Lux, G., Hägel, J., Backer, J. F. A. D., Backer, G. D., Vogl, R., Ruppin, H., Domschke, S., & Domschke, W. (1994) · Gut · doi:10.1136/gut.35.8.1026 · Cited by 89
Ceriani, G., Macaluso, A., Catania, A. P., & Lipton, J. M. (2008) · Neuroendocrinology · doi:10.1159/000126650 · Cited by 85
Butler, L. D., Layman, N. K., Riedl, P. E., Cain, R. L., Shellhaas, J., Evans, G. F., & Zuckerman, S. H. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90108-2 · Cited by 83
Nicotine Reduces the Incidence of Type I Diabetes in Mice
Mabley, J. G., Pacher, P., Southan, G. J., Salzman, A. L., & Szabó, C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.876 · Cited by 83
Autonomic neuropathy in rheumatoid arthritis.
EDMONDS, M. E., Jones, T., Saunders, W., & Sturrock, R. D. (1979) · BMJ · doi:10.1136/bmj.2.6183.173 · Cited by 82
Tracey, K. J., Czura, C. J., & Ivanova, S. (2001) · The FASEB Journal · doi:10.1096/fj.01-0148hyp · Cited by 79
Self-citationHermann, G. E., Emch, G. S., Tovar, C. A., & Rogers, R. C. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.1.r289 · Cited by 76
Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1β protein in rats
Hansen, M. K., Nguyen, K. T., Goehler, L. E., Gaykema, R. P. A., Fleshner, M., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00230-7 · Cited by 74
TNF-α activates solitary nucleus neurons responsive to gastric distension
Emch, G. S., Hermann, G., & Rogers, R. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.3.g582 · Cited by 74
Autonomic nervous system involvement in rheumatoid arthritis. 50 cases.
Toussirot, É., Serratrice, G., & Valentín, P. N. (1993) · PubMed · Cited by 68
Thermoregulatory manifestations of systemic inflammation: lessons from vagotomy
Romanovsky, A. A. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00218-6 · Cited by 66
Functional significance of coactivation of vagal and sympathetic cardiac nerves.
Koizumi, K., Terui, N., Kollai, M., & Brooks, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2116 · Cited by 63
Inhibition of acute inflammation in the periphery by central action of salicylates.
Catania, A. P., Arnold, J., Macaluso, A., Hiltz, M. E., & Lipton, J. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8544 · Cited by 61
Noguchi, E., & Hayashi, H. (1996) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.46.53 · Cited by 52
Wexler, B. C., DOLGIN, A. E., & TRYCZYNSKI, E. W. (1957) · Endocrinology · doi:10.1210/endo-61-3-300 · Cited by 48
Delgado, R., Demitri, M. T., Carlin, A., Meazza, C., Villa, P., Ghezzi, P., Lipton, J. M., & Catania, A. P. (1999) · NeuroImmunoModulation · doi:10.1159/000026381 · Cited by 44
Noradrenergic Inhibition of TNF Upregulation in Hemorrhagic Shock
Molina, P. E. (2001) · NeuroImmunoModulation · doi:10.1159/000049016 · Cited by 42
Exton, M. S., von Auer, A. K., Buske-Kirschbaum, A., Stockhorst, U., Göbel, U., & Schedlowski, M. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00191-6 · Cited by 41
Suppression of TNF and other proinflammatory cytokines by the tetravalent guanylhydrazone CNI-1493.
Tracey, K. J. (1998) · PubMed · Cited by 37
Self-citationVagus nerve stimulation: where are we?
Schachter, S. C. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200204000-00013 · Cited by 36
da Silva, V. J. D., Gnecchi‐Ruscone, T., Lavelli, B., Bellina, V., Manzella, D., Porta, A., Malliani, A., & Montano, N. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00608.2001 · Cited by 33
Tracey, K. J., & Abraham, E. (1999) · Shock · doi:10.1097/00024382-199903000-00012 · Cited by 32
Self-citationSYMPATHETIC SKIN RESPONSE AND R-R INTERVAL VARIATION IN RHEUMATOID ARTHRITIS
Tan, J., Akin, S., Beyazova, M., Sepici, V., & Tan, E. (1993) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-199308000-00005 · Cited by 31
Effect of nucleus tractus solitarius lesions on fever produced by interleukin-1β
Gordon, F. J. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00228-9 · Cited by 29
HEMORRHAGE ALTERS NEUROENDOCRINE, HEMODYNAMIC, AND COMPARTMENT-SPECIFIC TNF RESPONSES TO LPS
Molina, P. E., Bagby, G. J., & Stahls, P. F. (2001) · Shock · doi:10.1097/00024382-200116060-00010 · Cited by 28
Arai, I., Hirose, H., Muramatsu, M., Okuyama, S., & Aihara, H. (1985) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.37.91 · Cited by 22
HYPOPHYSECTOMY, HIGH TUMOR NECROSIS FACTOR LEVELS, AND HEMOGLOBINEMIA IN LETHAL ENDOTOXEMIC SHOCK
Bloom, O., Wang, H., Ivanova, S., Vishnubhakat, J. M., Ombrellino, M., & Tracey, K. J. (1998) · Shock · doi:10.1097/00024382-199812000-00003 · Cited by 19
Self-citation
Research works printed but not linked: 3
- Metal'nikov, S. a. V. C. Role des reflexes conditionnels dans l'immunite. Ann. Inst. Pasteur 40, 893–900 (1926).
- Ader R. & Cohen, N. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N) 3–34 (Academic, San Diego, 2001).
- Zachariae, R. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N.) 133–160 (Academic, San Diego, 2001).
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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citationAdverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
Inflammation 2010: New Adventures of an Old Flame
Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,928
The role of inflammation in epilepsy
Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876
Metadata
- Authors
- Tracey, K. J.
- Affiliations
- Northwell Health (US)
- Corresponding author
- Tracey, Kevin J.
- ORCID
- Tracey, Kevin J.
- Venue
- Nature
- Published
- 2002-12
- Volume
- 420
- Issue
- 6917
- Pages
- 853-859
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1995525413
- Cited by
- 3,728
- References
- 79
- Citations by year
- 2026: 264 · 2025: 197 · 2024: 177 · 2023: 172 · 2022: 208 · 2021: 204 · 2020: 179 · 2019: 180 · 2018: 160 · 2017: 150 · 2016: 161 · 2015: 150 · 2014: 162 · 2013: 171 · 2012: 157
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cholinergic anti-inflammatory pathway, cholinergic neurons, neuroimmune regulation, acute inflammation, inflammation treatment
- MeSH terms
- Animals, Antibodies, Monoclonal, Humans, Inflammation, Nervous System Physiological Phenomena, Reflex, Tumor Necrosis Factor-alpha, Vagus Nerve
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