Cited by 1,635T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

Janssen, Edith M., Lemmens, Edward E., Wolfe, Tom, Christen, Urs, von Herrath, Matthias G., Schoenberger, Stephen P.·2003·Nature

DOI 10.1038/nature01441

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Abstract

A long-standing paradox in cellular immunology concerns the conditional requirement for CD4+ T-helper (T(H)) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in vivo. Whereas CTL responses against certain viruses can be primed in the absence of CD4+ T cells, others, such as those mediated through 'cross-priming' by host antigen-presenting cells, are dependent on T(H) cells. A clearer understanding of the contribution of T(H) cells to CTL development has been hampered by the fact that most T(H)-independent responses have been demonstrated ex vivo as primary cytotoxic effectors, whereas T(H)-dependent responses generally require secondary in vitro re-stimulation for their detection. Here, we have monitored the primary and secondary responses of T(H)-dependent and T(H)-independent CTLs and find in both cases that CD4+ T cells are dispensable for primary expansion of CD8+ T cells and their differentiation into cytotoxic effectors. However, secondary CTL expansion (that is, a secondary response upon re-encounter with antigen) is wholly dependent on the presence of T(H) cells during, but not after, priming. Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen.

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Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
Self-citation
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 1×
“Although transition through these stages was thought to be governed by the presence and eventual elimination of antigen, mounting evidence suggests that CD8 p T-cell development is guided by an instructional programme that, once set into motion during priming, is executed independentl”
Background
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.
Dialynas, D. P., Quan, Z., Wall, K. A., Pierrès, A., Quintáns, J., Loken, M. R., Pierres, M., & Fitch, F. W. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2445 · Cited by 1,273
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
Kaech, S. M., & Ahmed, R. (2001) · Nature Immunology · doi:10.1038/87720 · Cited by 1,265
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
van Stipdonk, M. J. B., Lemmens, E. E., & Schoenberger, S. P. (2001) · Nature Immunology · doi:10.1038/87730 · Cited by 843
Self-citation
T Cell-Dependent B Cell Activation
Parker, D. C. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001555 · Cited by 739

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Colleton, B. A., Huang, X., Melhem, N. M., Fan, Z., Borowski, L., Rappocciolo, G., & Rinaldo, C. R. (2009) · Journal of Virology · doi:10.1128/jvi.02611-08 · Cited by 34
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Carey, A. J., Gracias, D. T., Thayer, J. L., Boesteanu, A. C., Kumova, O. K., Mueller, Y. M., Hope, J. L., Fraietta, J. A., van Zessen, D. B. H., & Katsikis, P. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502126 · Cited by 28
Precision T-cell therapy targets tumours
Melief, C. J. M. (2017) · Nature · doi:10.1038/nature23093 · Cited by 28
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Jiang, Z., Zhu, L., Cai, Y., Yan, J., Fan, Y., Lv, W., Gong, S., Yin, X., Yang, X., Sun, X., et al. (2020) · Veterinary Microbiology · doi:10.1016/j.vetmic.2020.108886 · Cited by 28
Antigen structure influences helper T‐cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120
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Doucet, J.-D., Forget, M., Grange, C., Rouxel, R. N., Arbour, N., von Messling, V., & Lapointe, R. (2011) · Journal of General Virology · doi:10.1099/vir.0.029777-0 · Cited by 28
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Roetynck, S., Olotu, A., Simam, J., Marsh, K., Stockinger, B., Urban, B. C., & Langhorne, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055195 · Cited by 28
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Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development
Betts, M. R., Gray, C. M., Cox, J. H., & Ferrari, G. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.4.505 · Cited by 28
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Wiesch, J. S. Z., Lauer, G. M., Timm, J., Kuntzen, T., Neukamm, M., Berical, A. C., Jones, A. M., Nolan, B. E., Longworth, S., Kasprowicz, V. O., et al. (2007) · Blood · doi:10.1182/blood-2007-01-069583 · Cited by 27
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Jing, L., McCaughey, S. M., Davies, D. H., Chong, T. M., Felgner, P. L., Rosa, S. C. D., Wilson, C. B., & Koelle, D. M. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.05.011 · Cited by 27
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Authors: Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P.
Affiliations: La Jolla Institute for Immunology (US)
Corresponding author: Schoenberger, Stephen P.
ORCID: Janssen, Edith M.
Lemmens, Edward E.
Christen, Urs
Schoenberger, Stephen P.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-02
Volume: 421
Issue: 6925
Pages: 852-856
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01441
OpenAlex: W1493822493
Cited by: 1,635
References: 28
Citations by year: 2026: 19 · 2025: 24 · 2024: 37 · 2023: 46 · 2022: 37 · 2021: 42 · 2020: 58 · 2019: 42 · 2018: 52 · 2017: 36 · 2016: 41 · 2015: 61 · 2014: 63 · 2013: 63 · 2012: 71
FWCI: 46.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: CD4+ T cells, CD8+ T cells, cytotoxic T lymphocytes, T helper cells, secondary immune response, T cell memory, T cell help, cross-priming, antigen-presenting cells, T cell differentiation
MeSH terms: Animals, Antigens, Cell Line, Cytotoxicity, Immunologic, Flow Cytometry, T-Lymphocytes, Helper-Inducer, Immunologic Memory, Lymphocyte Activation, Lymphocytic choriomeningitis virus, T-Lymphocytes, Cytotoxic, Mice

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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

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