Cited by 2,779Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismBiochemical Analysis and Sensing Techniques

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TRP channels as cellular sensors

Clapham, David E.·2003·Nature

DOI 10.1038/nature02196

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Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

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1 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

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Sorted by citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.-H., Tanasă, B., Hogan, P. G., Lewis, R. S., Daly, M. J., & Rao, A. (2006) · Nature · doi:10.1038/nature04702 · Cited by 2,329
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See all 2,779

Authors: Clapham, D. E.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Clapham, David E.
ORCID: Clapham, David E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 426
Issue: 6966
Pages: 517-524
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02196
OpenAlex: W2040664792
Cited by: 2,779
References: 100
Citations by year: 2026: 82 · 2025: 85 · 2024: 113 · 2023: 84 · 2022: 129 · 2021: 115 · 2020: 128 · 2019: 120 · 2018: 96 · 2017: 94 · 2016: 120 · 2015: 112 · 2014: 124 · 2013: 117 · 2012: 137
FWCI: 12.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: TRP channels, sensory transduction, temperature sensing, mechanosensing, pain, osmolarity, pheromones, taste, intracellular signaling, ion channels
MeSH terms: Animals, Calcium, Cells, Humans, Models, Biological, Calcium Channels, Signal Transduction, Ion Channel Gating, TRPC Cation Channels

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