The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Phospholipids and the origin of cationic gating charges in voltage sensors
Abstract
Cells communicate with their external environment through physical and chemical processes that take place in the cell-surrounding membrane. The membrane serves as a barrier as well as a special environment in which membrane proteins are able to carry out important processes. Certain membrane proteins have the ability to detect the membrane voltage and regulate ion conduction or enzyme activity. Such voltage-dependent processes rely on the action of protein domains known as voltage sensors, which are embedded inside the cell membrane and contain an excess of positively charged amino acids, which react to an electric field. How does the membrane create an environment suitable for voltage sensors? Here we show under a variety of conditions that the function of a voltage-dependent K+ channel is dependent on the negatively charged phosphodiester of phospholipid molecules. A non-voltage-dependent K+ channel does not exhibit the same dependence. The data lead us to propose that the phospholipid membrane, by providing stabilizing interactions between positively charged voltage-sensor arginine residues and negatively charged lipid phosphodiester groups, provides an appropriate environment for the energetic stability and operation of the voltage-sensing machinery. We suggest that the usage of arginine residues in voltage sensors is an adaptation to the phospholipid composition of cell membranes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, a shift in the ratio of specific GPL subclasses can affect membrane properties such as its fluidity and curvature, 25 which can further modulate neuronal excitability.45,47,71”
From Large neutral amino acid levels tune perinatal neuronal excitability and survival (2023) · cites this paper as [71]
Citations
Cites
Intermolecular and Surface Forces
(2011) · Elsevier eBooks · doi:10.1016/b978-0-12-391927-4.10024-6 · Cited by 17,242
Intermolecular and Surface Forces
(2011) · Elsevier eBooks · doi:10.1016/c2011-0-05119-0 · Cited by 9,159
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel
Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116269 · Cited by 2,159
Self-citationX-ray structure of a voltage-dependent K+ channel
Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadène, M., Chait, B. T., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01580 · Cited by 1,798
Self-citationCrystal structure and mechanism of a calcium-gated potassium channel
Jiang, Y., Lee, A., Chen, J., Cadène, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/417515a · Cited by 1,332
Self-citationVoltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 982
Self-citationThe principle of gating charge movement in a voltage-dependent K+ channel
Jiang, Y., Ruta, V., Chen, J., Lee, A., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01581 · Cited by 781
Self-citationPhosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
Murata, Y., Iwasaki, H., Sasaki, M., Inaba, K., & Okamura, Y. (2005) · Nature · doi:10.1038/nature03650 · Cited by 673
Miller, C. (1986) · Springer eBooks · doi:10.1007/978-1-4757-1361-9 · Cited by 605
Voltage gating of ion channels
Sigworth, F. J. (1994) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500002894 · Cited by 413
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 417
Tanaka, B. S., Nguyen, P. T., Zhou, E. Y., Yang, Y., Yarov-Yarovoy, V. M., Dib‐Hajj, S. D., & Waxman, S. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.778779 · Cited by 28
Pseudo painting/air bubble technique for planar lipid bilayers
Braun, C., Baer, T., Moroni, A., & Thiel, G. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.05.031 · Cited by 28
Kalia, J., & Swartz, K. J. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.074989 · Cited by 28
Vamvouka, M., Cieslak, J. A., Eps, N. V., Hubbell, W. L., & Gross, A. (2008) · Protein Science · doi:10.1110/ps.073310008 · Cited by 28
Montenegro, J., Fin, A., & Matile, S. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00948b · Cited by 27
Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel
Kim, I., & Warshel, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324014111 · Cited by 27
Mlayeh, L., Krammer, E., Léonetti, M., Prévost, M., & Homblé, F. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.06.005 · Cited by 26
Raja, M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.03.010 · Cited by 26
Whitfield, T., Miles, A. J., Scheinost, J. C., Offer, J., Wentworth, P., Dwek, R. A., Wallace, B. A., Biggin, P. C., & Zitzmann, N. (2011) · Molecular Membrane Biology · doi:10.3109/09687688.2011.581253 · Cited by 26
Miceli, F., Soldovieri, M. V., Iannotti, F. A., Barrese, V., Ambrosino, P., Martire, M., Cilio, M. R., & Taglialatela, M. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00002 · Cited by 26
The Membrane-Bound State of K2P Potassium Channels
Treptow, W. L., & Klein, M. L. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102191s · Cited by 25
Interface Engineering of Synthetic Pores: Towards Hypersensitive Biosensors
Mora, F., Tran, D., Oudry, N., Gérard Hopfgartner, D., Jeannerat, D., Sakai, N., & Matile, S. (2007) · Chemistry - A European Journal · doi:10.1002/chem.200701520 · Cited by 25
Glycosylated Cell‐Penetrating Peptides (GCPPs)
Gallego, I., Rioboo, A., Reina, J. J., Díaz, B., Canales, Á., Cañada, F. J., Guerra‐Varela, J., Sanchez, L. E., & Montenegro, J. (2019) · ChemBioChem · doi:10.1002/cbic.201800720 · Cited by 24
Interactions Between a Voltage Sensor and a Toxin via Multiscale Simulations
Wee, C. L., Gavaghan, D. J., & Sansom, M. S. P. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.4321 · Cited by 24
Tracking Membrane Protein Dynamics in Real Time
Orädd, F., & Andersson, M. (2021) · The Journal of Membrane Biology · doi:10.1007/s00232-020-00165-8 · Cited by 25
Voltage Gated Ion Channel Function: Gating, Conduction, and the Role of Water and Protons
Kariev, A. M., & Green, M. E. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13021680 · Cited by 23
Jarecki, B. W., Makino, S., Beebe, E. T., Fox, B. G., & Chanda, B. (2013) · Scientific Reports · doi:10.1038/srep01040 · Cited by 23
Differential Lipid Dependence of the Function of Bacterial Sodium Channels
D’Avanzo, N., McCusker, E. C., Powl, A. M., Miles, A. J., Nichols, C. G., & Wallace, B. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061216 · Cited by 22
Phosphatidic Acid: An Electrostatic/Hydrogen-Bond Switch?
Kooijman, E. E., & Testerink, C. S. (2009) · Plant cell monographs · doi:10.1007/978-3-642-03873-0_14 · Cited by 24
Tarek, M., & Delemotte, L. (2013) · Accounts of Chemical Research · doi:10.1021/ar300290u · Cited by 22
Reduced voltage sensitivity in a K + -channel voltage sensor by electric field remodeling
Gonzalez-Perez, V. M., Stack, K., Boric, K., & Naranjo, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000963107 · Cited by 22
Structural Interactions between Lipids, Water and S1–S4 Voltage-Sensing Domains
Krepkiy, D. V., Gawrisch, K., & Swartz, K. J. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.07.015 · Cited by 22
Ethynyl benziodoxolones: functional terminators for cell-penetrating poly(disulfide)s
Morelli, P., Martin‐Benlloch, X., Tessier, R., Waser, J., Sakai, N., & Matile, S. (2016) · Polymer Chemistry · doi:10.1039/c6py00562d · Cited by 22
Probing membrane protein properties using droplet interface bilayers
Allen-Benton, M. P., Findlay, H. E., & Booth, P. J. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219847939 · Cited by 22
Beilstein Journal of Organic Chemistry
(2019) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc · Cited by 22
Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site
Sridhar, A., Lummis, S. C. R., Pasini, D., Mehregan, A., Brams, M., Kambara, K., Bertrand, D., Lindahl, E. R., Howard, R. J., & Ulens, C. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100899 · Cited by 18
Energetic role of the paddle motif in voltage gating of Shaker K+ channels
Xu, Y., Ramu, Y., Shin, H.-G., Yamakaze, J., & Lü, Z. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2535 · Cited by 21
New Disaccharide‐Based Ether Lipids as SK3 Ion Channel Inhibitors
Berthe, W., Sevrain, C. M., Chantôme, A., Bouchet, A. M., Guéguinou, M., Fourbon, Y., Potier‐Cartereau, M., Haelters, J., Couthon‐Gourvès, H., Vandier, C., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201600147 · Cited by 21
Coupling between the voltage-sensing and pore domains in a voltage-gated potassium channel
Schow, E. V., Freites, J. A., Nizkorodov, A., White, S. H., & Tobias, D. J. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.02.029 · Cited by 21
In Vitro Folding of KvAP, a Voltage-Gated K+ Channel
Devaraneni, P. K., Devereaux, J., & Valiyaveetil, F. I. (2011) · Biochemistry · doi:10.1021/bi2012965 · Cited by 21
Fluorescence Techniques for Determination of the Membrane Potentials in High Throughput Screening
Przybyło, M., Borowik, T., & Langner, M. (2010) · Journal of Fluorescence · doi:10.1007/s10895-010-0665-6 · Cited by 20
Ben-Zeev, G., Telias, M., & Nussinovitch, I. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.04.006 · Cited by 20
Ben-Zeev, G., Telias, M., Bert, D., & Nussinovitch, I. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.093 · Cited by 19
Ahrens, J., Foadi, N., Eberhardt, A., Haeseler, G., Dengler, R., Leffler, A., Mühlenhoff, M., Gerardy‐Schahn, R., & Leuwer, M. (2011) · Pharmacology · doi:10.1159/000327389 · Cited by 19
Membrane Insertion of a Voltage Sensor Helix
Wee, C. L., Chetwynd, A. P., & Sansom, M. S. P. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.12.3682 · Cited by 19
Song, S., Cheong, L., Man, Q., Pang, S., Li, Y.-Q., Ren, B., & Zhang, J. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-0975-0 · Cited by 19
Saffari, M., Shirazi, F. H., Oghabian, M. A., & Moghimi, H. R. (2013) · Europe PMC (PubMed Central) · Cited by 18
Review: Placental syncytiotrophoblast membranes – domains, subdomains and microdomains
Riquelme, G. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.002 · Cited by 18
Functional reconstitution of cell-free synthesized purified Kv channels
Renauld, S., Cortès, S., Bersch, B., Henry, X., WAARD, M. M. D., & Schaack, B. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.09.002 · Cited by 18
Structural Dynamics of the S4 Voltage-Sensor Helix in Lipid Bilayers Lacking Phosphate Groups
Andersson, M., Freites, J. A., Tobias, D. J., & White, S. H. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp2001964 · Cited by 17
Accessibility of Four Arginine Residues on the S4 Segment of the Bacillus halodurans Sodium Channel
Blanchet, J., & Chahine, M. (2007) · The Journal of Membrane Biology · doi:10.1007/s00232-007-9016-1 · Cited by 17
Do Lipids Show State-dependent Affinity to the Voltage-gated Potassium Channel KvAP?
Faure, É., Thompson, C., & Blunck, R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537134 · Cited by 17
Structural Dynamics of the Paddle Motif Loop in the Activated Conformation of KvAP Voltage Sensor
Das, A., Chatterjee, S., & Raghuraman, H. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.08.017 · Cited by 17
Dixit, G., Sahu, I. D., Reynolds, W. D., Wadsworth, T. M., Harding, B. D., Jaycox, C. K., Dabney‐Smith, C., Sanders, C. R., & Lorigan, G. A. (2019) · Biochemistry · doi:10.1021/acs.biochem.8b01042 · Cited by 17
Ramirez, P. G. T., Pópolo, M. G. D., Vila, J. A., Szleifer, I. G., & Longo, G. S. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.05.087 · Cited by 17
Position and motions of the S4 helix during opening of the Shaker potassium channel
Phillips, L. R., & Swartz, K. J. (2010) · The Journal of General Physiology · doi:10.1085/jgp.201010517 · Cited by 17
Dynamics of activation in the voltage-sensing domain of Ciona intestinalis phosphatase Ci-VSP
Guo, S. C., Shen, R., Roux, B., & Dinner, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-45514-6 · Cited by 16
Lipid Regulation of Sodium Channels
D’Avanzo, N. (2016) · Current topics in membranes · doi:10.1016/bs.ctm.2016.04.003 · Cited by 17
Structure of the Human BK Ion Channel in Lipid Environment
Tonggu, L., & Wang, L. (2022) · Membranes · doi:10.3390/membranes12080758 · Cited by 16
Balajthy, A., Somodi, S., Pethő, Z., Péter, M., Varga, Z., Szabó, G. P., Paragh, G., Vígh, L., Panyi, G., & Hajdú, P. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1851-4 · Cited by 17
McKeown, L., Burnham, M. P., Hodson, C., & Jones, O. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708921200 · Cited by 15
The conformational shifts of the voltage sensing domains between NavRh and NavAb
Zhang, X., & Yan, N. (2012) · Cell Research · doi:10.1038/cr.2012.158 · Cited by 15
Lipid Flip-Flop and Pore Nucleation on Zwitterionic Bilayers are Asymmetric under Ionic Imbalance
Lin, J., Dargazany, R., & Alexander‐Katz, A. (2017) · Small · doi:10.1002/smll.201603708 · Cited by 16
Mapping the Membrane-aqueous Border for the Voltage-sensing Domain of a Potassium Channel
Neale, E. J., Rong, H., Cockcroft, C. J., & Sivaprasadarao, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706437200 · Cited by 15
Mokrab, Y., & Sansom, M. S. P. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.11.049 · Cited by 14
A multi-scale molecular dynamics simulation of PMAL facilitated delivery of siRNA
Li, J., Ouyang, Y., Kong, X., Zhu, J., Lu, D., & Liu, Z. (2015) · RSC Advances · doi:10.1039/c5ra10965e · Cited by 14
In Vitro Folding of KvAP, a Voltage Gated K+ Channel
Devaraneni, P. K., & Valiyaveetil, F. I. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.1461 · Cited by 14
Gupta, S., Dura, J. A., Freites, J. A., Tobias, D. J., & Blasie, J. K. (2012) · Langmuir · doi:10.1021/la301219z · Cited by 14
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels
Perry, M., Wong, S., Ng, C., & Vandenberg, J. I. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201310975 · Cited by 14
Bhargava, P., Singh, M. P., Sreekanth, V., & Bajaj, A. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp504104a · Cited by 14
Wang, G. (2008) · The Open Magnetic Resonance Journal · doi:10.2174/1874769800801010009 · Cited by 14
Modeling gating charge and voltage changes in response to charge separation in membrane proteins
Kim, I., Chakrabarty, S., Brzezinski, P., & Warshel, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411573111 · Cited by 13
Mathematical models of ion transport through cell membrane channels
Miȩkisz, J., Gomułkiewicz, J., & Mie̢kisz, S. (2014) · Roczniki Polskiego Towarzystwa Matematycznego. Seria 3, Matematyka Stosowana/Matematyka Stosowana/Mathematica Applicanda · doi:10.14708/ma.v42i1.469 · Cited by 13
Gong, X., Ding, Y., Yu, J., Yao, Y., & Marassi, F. M. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.04.021 · Cited by 13
Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain
Gourgy-Hacohen, O., Kornilov, P., Pittel, I., Peretz, A. S., Attali, B., & Paas, Y. (2014) · The Journal of General Physiology · doi:10.1085/jgp.201411221 · Cited by 13
Voltage-sensitive ion channels, acidic lipids and Hodgkin–Huxley equations: New ideas 55 years later
Kocherginsky, N. (2008) · Journal of Membrane Science · doi:10.1016/j.memsci.2008.10.024 · Cited by 13
Zheng, H., Lee, S., Llaguno, M. C., & Jiang, Q. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201511448 · Cited by 13
Self-citationNon-linear Conductance, Rectification, and Mechanosensitive Channel Formation of Lipid Membranes
Zecchi, K. A., & Heimburg, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.592520 · Cited by 13
Takeuchi, T., Sakai, N., & Matile, S. (2009) · Faraday Discussions · doi:10.1039/b900133f · Cited by 13
Sun, Z., Xu, Y., Zhang, D., & McDermott, A. E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908828117 · Cited by 12
Fine-tuning of Voltage Sensitivity of the Kv1.2 Potassium Channel by Interhelix Loop Dynamics
Sand, R. M., Sharmin, N., Morgan, C., & Gallin, W. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437483 · Cited by 12
Scornik, F. S., Bucciero, R. S., Wu, Y., Selga, E., Calero, C. B., Brugada, R., & Pérez, G. J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00939.2012 · Cited by 12
Ramirez, P. G. T., Pópolo, M. G. D., Vila, J. A., & Longo, G. S. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp02770g · Cited by 12
A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide
Saikia, C., Dym, O., Altman-Gueta, H., Gordon, D., Reuveny, E., & Karbat, I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166957 · Cited by 12
Determinants of conductance of a bacterial voltage-gated sodium channel
Chen, A. Y., Brooks, B. R., & Damjanovic, A. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.06.013 · Cited by 11
A hydrophobic element secures S4 voltage sensor in position in resting Shaker K+ channels
Yang, Y., Own, C., & Kuo, C. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.131490 · Cited by 12
Rhomboid intramembrane protease structures galore!
White, S. H. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1206-1049 · Cited by 12
Schniederberend, M., Zimmann, P., Bogdanov, M. V., Dowhan, W., & Altendorf, K. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.10.002 · Cited by 12
How to Understand Lipid–Protein Interactions in Biological Membranes
Lee, A. J. (2011) · CRC Press eBooks · doi:10.1201/b11018-14 · Cited by 12
Guo, Y., Werner, M., Fleury, J., & Baulin, V. A. (2020) · Physical Review Letters · doi:10.1103/physrevlett.124.038001 · Cited by 11
Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
Strege, P. R., Cowan, L. M., Alcaino, C., Mazzone, A., Ahern, C. A., Milescu, L. S., Farrugia, G., & Beyder, A. (2023) · eLife · doi:10.7554/elife.79271 · Cited by 11
Role of terminal dipole charges in aggregation of α-helix pair in the voltage gated K+ channel
Adhya, L., Mapder, T., & Adhya, S. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.11.008 · Cited by 11
Wang, W., & van Veen, H. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038715 · Cited by 11
Das, A., & Raghuraman, H. (2021) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2021.183568 · Cited by 11
The sliding-helix voltage sensor: mesoscale views of a robust structure–function relationship
Peyser, A., & Nonner, W. (2012) · European Biophysics Journal · doi:10.1007/s00249-012-0847-z · Cited by 11
Ahangar, A. A., Elhanafy, E., Blanton, H., & Li, J. (2024) · iScience · doi:10.1016/j.isci.2024.110678 · Cited by 9
Díaz-Franulic, I., Gonzalez-Perez, V. M., Moldenhauer, H. J., Navarro‐Quezada, N., & Naranjo, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806578115 · Cited by 10
Oligomers of Cyclic Oligochalcogenides for Enhanced Cellular Uptake
Martinent, R., Du, D., López‐Andarias, J., Sakai, N., & Matile, S. (2020) · ChemBioChem · doi:10.1002/cbic.202000630 · Cited by 10
Liu, T., Pang, S., Jia, S., Man, Q., Li, Y., Song, S., & Zhang, J. (2021) · Nutrients · doi:10.3390/nu13072185 · Cited by 12
Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies
Lee, S., Zheng, H., Shi, L., & Jiang, Q. (2013) · Journal of Visualized Experiments · doi:10.3791/50436 · Cited by 10
Self-citationLEE, A. G. J. (2006) · Nature · doi:10.1038/nature05408 · Cited by 10
Lin, Y., Tao, E., Champion, J. P., & Corry, B. (2023) · eLife · doi:10.7554/elife.91218 · Cited by 9
Portella, G., Polupanow, T., Zocher, F., Boytsov, D., Pohl, P., Diederichsen, U., & de Groot, B. L. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.08.059 · Cited by 9
Structure-activity relationships of ω-Agatoxin IVA in lipid membranes
Ryu, J. H., Jung, H. J., Konishi, S., Kim, H. H., Park, Z., & Kim, J. I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.025 · Cited by 9
EPR Studies of Gating Mechanisms in Ion Channels
Chakrapani, S. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.12.030 · Cited by 9
Zubcevic, L. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15310 · Cited by 9
Broken Symmetry in the Human BK ChannelPreprint
Tonggu, L., & Wang, L. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3310822 · Cited by 9
Lipid Bilayer Modules as Determinants of K+ Channel Gating
Syeda, R., Santos, J. S., & Montal, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530055 · Cited by 8
Expression, Purification, and Reconstitution of the Voltage-Sensing Domain from Ci-VSP
Li, Q., Jogini, V., Wanderling, S. S., Cortés, D. M., & Perozo, E. (2012) · Biochemistry · doi:10.1021/bi300980q · Cited by 8
Imbrici, P., Accogli, A., Blunck, R., Altamura, C., Iacomino, M., D’Adamo, M. C., Allegri, A. E. M., Pedemonte, M., Brolatti, N., Vari, S., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010075 · Cited by 8
Metadata
- Authors
- Schmidt, D., Jiang, Q.-X., & MacKinnon, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- MacKinnon, Roderick
- Venue
- Nature
- Published
- 2006-11-29
- Volume
- 444
- Issue
- 7120
- Pages
- 775-779
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2022309859
- Cited by
- 417
- References
- 21
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 18 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 36 · 2013: 29 · 2012: 32
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM043949)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- voltage sensor, phospholipids, potassium channels, arginine residues, membrane lipid composition, membrane potential, voltage-gated ion channels, membrane protein stability
- MeSH terms
- Cations, Lipid Bilayers, Liposomes, Phospholipids, Ion Channel Gating, Potassium Channels, Voltage-Gated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review