Cited by 475Vagus Nerve Stimulation ResearchCancer, Stress, Anesthesia, and Immune ResponseInflammation biomarkers and pathways

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Phagocyte-derived catecholamines enhance acute inflammatory injury

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Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Chen, Anthony J., Sarma, J. Vidya, Zetoune, Firas S., McGuire, Stephanie R., List, Rachel P., Day, Danielle E., Hoesel, L. Marco, Gao, Hongwei, Van Rooijen, Nico, Huber-Lang, Markus S., Neubig, Richard R., Ward, Peter A.·2007·Nature

DOI 10.1038/nature06185

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Abstract

It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic and parasympathetic pathways. We investigated whether phagocytes are capable of de novo production of catecholamines, suggesting an autocrine/paracrine self-regulatory mechanism by catecholamines during inflammation, as has been described for lymphocytes. Here we show that exposure of phagocytes to lipopolysaccharide led to a release of catecholamines and an induction of catecholamine-generating and degrading enzymes, indicating the presence of the complete intracellular machinery for the generation, release and inactivation of catecholamines. To assess the importance of these findings in vivo, we chose two models of acute lung injury. Blockade of alpha2-adrenoreceptors or catecholamine-generating enzymes greatly suppressed lung inflammation, whereas the opposite was the case either for an alpha2-adrenoreceptor agonist or for inhibition of catecholamine-degrading enzymes. We were able to exclude T cells or sympathetic nerve endings as sources of the injury-modulating catecholamines. Our studies identify phagocytes as a new source of catecholamines, which enhance the inflammatory response.

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Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
The inflammatory reflex
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
International Union of Pharmacology nomenclature of adrenoceptors.
Bylund, D., Eikenberg, D. C., Hieble, J. P., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P., Molinoff, P. B., Ruffolo, R. R., & TRENDELENBURG, U. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06780-8 · Cited by 1,204
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Generation of C5a in the absence of C3: a new complement activation pathway
Huber-Lang, M. S., Sarma, J. V., Zetoune, F. S., Rittirsch, D., Neff, T. A., McGuire, S. R., Lambris, J. D., Warner, R. L., Flierl, M. A., Hoesel, L. M., et al. (2006) · Nature Medicine · doi:10.1038/nm1419 · Cited by 976
Self-citation
Toll-like receptors in the pathogenesis of human disease
Cook, D. N., Pisetsky, D. S., & Schwartz, D. A. (2004) · Nature Immunology · doi:10.1038/ni1116 · Cited by 827
Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help
Sanders, V. M., Baker, R. A., Ramer-Quinn, D. S., Kasprowicz, D. J., Fuchs, B. A., & Street, N. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4200 · Cited by 434
Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor.
Spengler, R. N., Allen, R., Remick, D. G., Strieter, R. M., & Kunkel, S. L. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.5.1430 · Cited by 388

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Hoffman, B. B. in Goodman & Gilman’s The Pharmacological Basics of Therapeutics (eds Brunton, L. L., Lazo, J. S. & Parker, K. L.) 845–868 (McGraw-Hill, New York, 2006)

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Giebelen, I. A. J., Leendertse, M., Dessing, M. C., Meijers, J. C. M., Levi, M. M., Draing, C., von Aulock, S., & van der Poll, T. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0439oc · Cited by 13
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A novel nervous system‐induced factor inducing immune responses in the spleen
Bakhiet, M., & Taha, S. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.57 · Cited by 13
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Luo, P., Liu, D., & Li, J. (2020) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2020-002295 · Cited by 11
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Enten, G. A., Gao, X., Strzelinski, H. R., Weche, M., Liggett, S. B., & Majetschak, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2123511119 · Cited by 11
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Gomes, A., Soares, R. A., Costa, R., Marino, F., Cosentino, M., Malagón, M. M., & Ribeiro, L. V. P. T. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01971-0 · Cited by 11
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Das, U. N. (2011) · Springer eBooks · doi:10.1007/978-94-007-0495-4_3 · Cited by 11
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Self-citation
Effect of α2-adrenergic agonists and antagonists on cytokine release from human lung macrophages cultured in vitro
Piazza, O., Staiano, R. I., ROBERTIS, E. D., Conti, G., Crescenzo, V. G. D., Loffredo, S., Marone, G., Marinosci, G. Z., & Cataldi, M. (2016) · PubMed Central · doi:10.14273/unisa-2673 · Cited by 11
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Mechanism and impact of catecholamine conversion by Vibrio cholerae
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Authors: Flierl, M. A., Rittirsch, D., Nadeau, B. A., Chen, A. J., Sarma, J. V., Zetoune, F. S., McGuire, S. R., List, R. P., Day, D. E., Hoesel, L. M., Gao, H., Van Rooijen, N., Huber-Lang, M. S., Neubig, R. R., & Ward, P. A.
Affiliations: University of Michigan (US)
Universität Ulm (DE)
Corresponding author: Ward, Peter A.
ORCID: Flierl, Michael A.
Rittirsch, Daniel
Nadeau, Brian A.
Gao, Hongwei
Huber-Lang, Markus S.
Neubig, Richard R.
Ward, Peter A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-09-30
Volume: 449
Issue: 7163
Pages: 721-725
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06185
OpenAlex: W2058021161
Cited by: 475
References: 26
Citations by year: 2026: 17 · 2025: 18 · 2024: 26 · 2023: 16 · 2022: 24 · 2021: 25 · 2020: 29 · 2019: 35 · 2018: 26 · 2017: 22 · 2016: 26 · 2015: 34 · 2014: 20 · 2013: 27 · 2012: 22
FWCI: 14.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
National Institutes of Health
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: phagocytes, catecholamines, norepinephrine, epinephrine, acute lung injury, macrophages, neutrophils, lipopolysaccharide, alpha2-adrenoceptors, adrenergic system, neuroimmune interactions, autocrine and paracrine regulation, inflammatory injury
MeSH terms: Acute Disease, Animals, Catecholamines, Inflammation, Lipopolysaccharides, Lung Diseases, Macrophages, Male, Neutrophils, Phagocytes, T-Lymphocytes, Receptors, Adrenergic, alpha-2, Rats, Long-Evans, Rats, Adrenergic alpha-2 Receptor Antagonists

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