The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A newly discovered protein export machine in malaria parasites
Open accessAbstract
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and into the cytosol of the host erythrocyte, a process that is central to the virulence and viability of the causative Plasmodium species. The trafficking machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported proteins (PTEX), which is located in the vacuole membrane. The PTEX complex is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a novel protein termed PTEX150 and a known parasite protein, exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, a new protein PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. As a common portal for numerous crucial processes, this translocon offers a new avenue for therapeutic intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The economic and social burden of malaria
Sachs, J., & Malaney, P. (2002) · Nature · doi:10.1038/415680a · Cited by 2,248 · cited 3×
“Right, the total number of peptides present in all excised bands for those parasite-specific proteins that were the top peptide hit in the visible bands unique to pull-downs using transgenic parasites (labelled (1)–(5)), and the peptide abundance of Pfcdc48 and all other parasite and host cell proteins identified.”
Background
Cited by
Kehrer, J., Frischknecht, F., & Mair, G. R. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.058263 · Cited by 105
Davies, H., Belda, H., Broncel, M., Dalimot, J., & Treeck, M. (2023) · eLife · doi:10.7554/elife.86367 · Cited by 17
Ling, D. B., Nguyen, W., Looker, O., Razook, Z., McCann, K., Barry, A. E., Scheurer, C., Wittlin, S., Famodimu, M. T., Delves, M. J., et al. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00138 · Cited by 6
Self-citation
Metadata
- Authors
- de Koning-Ward, T. F., Gilson, P. R., Boddey, J. A., Rug, M., Smith, B. J., Papenfuss, A. T., Sanders, P. R., Lundie, R. J., Maier, A. G., Cowman, A. F., & Crabb, B. S.
- Venue
- Nature
- Published
- 2009-06
- Volume
- 459
- Issue
- 7249
- Pages
- 945-949
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2068928962
- Cited by
- 497
- References
- 1
- FWCI
- 37.05
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A newly discovered protein export machine in malaria parasites. https://app.cochat.ai/papers/10.1038/nature08104
- The paper
- de Koning-Ward, T. F., Gilson, P. R., Boddey, J. A., Rug, M., Smith, B. J., Papenfuss, A. T., Sanders, P. R., Lundie, R. J., Maier, A. G., Cowman, A. F., & Crabb, B. S. (2009). A newly discovered protein export machine in malaria parasites. Nature. https://doi.org/10.1038/nature08104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
