The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
An oestrogen-receptor-α-bound human chromatin interactome
Open accessAbstract
Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind to regulatory DNA elements distant from gene promoters. Although distal binding sites have been shown to regulate transcription by long-range chromatin interactions at a few loci, chromatin interactions and their impact on transcription regulation have not been investigated in a genome-wide manner. Here we describe the development of a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global chromatin interactions, with which we have comprehensively mapped the chromatin interaction network bound by oestrogen receptor α (ER-α) in the human genome. We found that most high-confidence remote ER-α-binding sites are anchored at gene promoters through long-range chromatin interactions, suggesting that ER-α functions by extensive chromatin looping to bring genes together for coordinated transcriptional regulation. We propose that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes.
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Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
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Self-citationQuantitative analysis of chromosome conformation capture assays (3C-qPCR)
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An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212
Differential analysis of gene regulation at transcript resolution with RNA-seq
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Self-citationThree-dimensional folding and functional organization principles of the Drosophila genome
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Metadata
- Authors
- Fullwood, M. J., Liu, M. H., Pan, Y. F., Liu, J., Xu, H., Mohamed, Y. B., Orlov, Y. L., Velkov, S., Ho, A., Mei, P. H., Chew, E. G. Y., Huang, P. Y. H., Welboren, W.-J., Han, Y., Ooi, H. S., Ariyaratne, P. N., Vega, V. B., Luo, Y., Tan, P. Y., Choy, P. Y., Wansa, K. D. S. A., Zhao, B., Lim, K. S., Leow, S. C., Yow, J. S., Joseph, R., Li, H., Desai, K. V., Thomsen, J. S., Lee, Y. K., Karuturi, R. K. M., Herve, T., Bourque, G., Stunnenberg, H. G., Ruan, X., Cacheux-Rataboul, V., Sung, W.-K., Liu, E. T., Wei, C.-L., Cheung, E., & Ruan, Y.
- Venue
- Nature
- Published
- 2009-11
- Volume
- 462
- Issue
- 7269
- Pages
- 58-64
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1985621639
- Cited by
- 1,721
- References
- 6
- FWCI
- 37.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Fullwood, M. J., Liu, M. H., Pan, Y. F., Liu, J., Xu, H., Mohamed, Y. B., Orlov, Y. L., Velkov, S., Ho, A., Mei, P. H., Chew, E. G. Y., Huang, P. Y. H., Welboren, W.-J., Han, Y., Ooi, H. S., Ariyaratne, P. N., Vega, V. B., Luo, Y., Tan, P. Y., . . . Ruan, Y. (2009). An oestrogen-receptor-α-bound human chromatin interactome. Nature. https://doi.org/10.1038/nature08497
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