Neural bases for addictive properties of benzodiazepines

Tan, Kelly R., Brown, Matthew, Labouèbe, Gwenaël, Yvon, Cédric, Creton, Cyril, Fritschy, Jean-Marc, Rudolph, Uwe, Lüscher, Christian·2010·Nature

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    2013 · Elsevier eBooks
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  62. References
    Brian S. Fulton · 2014 · Wiley eBooks
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    2017 · Elsevier eBooks
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  81. Additional file 1 of Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
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  83. Impact of the administration of α-casozepine, a benzodiazepine-like peptide from bovine αs1-casein, and of a proteolysis fragment on neural activity in mice
    Simon Benoit · 2017
  84. Rang social, système dopaminergique et réponse au stress
    Dorian Battivelli · 2019 · theses.fr (ABES)
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    Géraldine Gazzo · 2020
  86. Role of the endocannabinoid system in exercise motivation
    Bastien Redon · 2021 · theses.fr (ABES)
  87. Diversité des effets de la nicotine sur les neurones dopaminergiques de l’aire tegmentale ventrale
    Claire Nguyen · 2020 · theses.fr (ABES)
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  95. BindingDB Entry 50000733: Synthesis and Characterization of a Novelγ-Aminobutyric Acid Type A (GABA
    BindingDB · 2020 · UC San Diego
  96. BindingDB Entry 50023168: Structural Studies of the Dopamine D4 Receptor Antagonist Sonepiprazole as an Inhibitor of Human Carbonic Anhydrases.
    BindingDB · 2026 · UC San Diego
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  98. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia
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