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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Open accessAbstract
Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.
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Whelan, S., & Goldman, N. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003851 · Cited by 2,849
Cited by
O'Connell, R. J., Thon, M. R., Hacquard, S., Amyotte, S. G., Kleemann, J., Torres, M. F., Damm, U., Buiate, E. A., Epstein, L., Alkan, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2372 · Cited by 1,047
Self-citationThe Spectrum of Fungi That Infects Humans
Kohler, J. R., Casadevall, A., & Perfect, J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019273 · Cited by 364
A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi
Hane, J. K., Rouxel, T., Howlett, B. J., Kema, G. H., Goodwin, S. B., & Oliver, R. P. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r45 · Cited by 169
Baroncelli, R., Amby, D. B., Zapparata, A., Sarrocco, S., Vannacci, G., Le Floch, G., Harrison, R. J., Holub, E., Sukno, S. A., Sreenivasaprasad, S., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-2917-6 · Cited by 179
AlphaFold-Multimer predicts cross-kingdom interactions at the plant-pathogen interface
Homma, F., Huang, J., & van der Hoorn, R. A. L. (2023) · Nature Communications · doi:10.1038/s41467-023-41721-9 · Cited by 176
Metadata
- Authors
- Ma, L.-J., van der Does, H. C., Borkovich, K. A., Coleman, J. J., Daboussi, M.-J., Di Pietro, A., Dufresne, M., Freitag, M., Grabherr, M., Henrissat, B., Houterman, P. M., Kang, S., Shim, W.-B., Woloshuk, C., Xie, X., Xu, J.-R., Antoniw, J., Baker, S. E., Bluhm, B. H., Breakspear, A., Brown, D. W., Butchko, R. A. E., Chapman, S., Coulson, R., Coutinho, P. M., Danchin, E. G. J., Diener, A., Gale, L. R., Gardiner, D. M., Goff, S., Hammond-Kosack, K. E., Hilburn, K., Hua-Van, A., Jonkers, W., Kazan, K., Kodira, C. D., Koehrsen, M., Kumar, L., Lee, Y.-H., Li, L., Manners, J. M., Miranda-Saavedra, D., Mukherjee, M., Park, G., Park, J., Park, S.-Y., Proctor, R. H., Regev, A., Ruiz-Roldan, M. C., Sain, D., Sakthikumar, S., Sykes, S., Schwartz, D. C., Turgeon, B. G., Wapinski, I., Yoder, O., Young, S., Zeng, Q., Zhou, S., Galagan, J., Cuomo, C. A., Kistler, H. C., & Rep, M.
- Venue
- Nature
- Published
- 2010-03
- Volume
- 464
- Issue
- 7287
- Pages
- 367-373
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2171468101
- Cited by
- 1,772
- References
- 1
- FWCI
- 35.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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