Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219

Heart Regeneration in Zebrafish

Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,938

The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs

Kwan, K. M., Fujimoto, E., Grabher, C., Mangum, B. D., Hardy, M., Campbell, D. S., Parant, J. M., Yost, H. J., Kanki, J. P., & Chien, C.-B. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21343 · Cited by 1,768

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

Bersell, K. R., Arab, S., Haring, B., & Kühn, B. (2009) · Cell · doi:10.1016/j.cell.2009.04.060 · Cited by 1,053

Practical Methods in Electron Microscopy

Corliss, J. O., & Glauert, A. M. (1973) · Transactions of the American Microscopical Society · doi:10.2307/3224938 · Cited by 1,012

A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration

Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 848

Controlled expression of transgenes introduced by in vivo electroporation

Matsuda, T., & Cepko, C. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610155104 · Cited by 666

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytesPreprint

Engel, F. B., Schebesta, M., Duong, M. T., Lü, G., Ren, S. V., Madwed, J. B., Jiang, H., Wang, Y., & Keating, M. T. (2005) · Genes & Development · doi:10.1101/gad.1306705 · Cited by 595

Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies

Curado, S., Anderson, R. M., Jungblut, B., Mumm, J. S., Schroeter, E. H., & Stainier, D. Y. R. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21100 · Cited by 509

Germ‐line transmission of a myocardium‐specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish

Huang, C., Tu, C., Hsiao, C., Hsieh, F., & Tsai, H. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10356 · Cited by 506

Life Before Nkx2.5

Scott, I. C. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00001-4 · Cited by 27

Redox Signaling in Cardiac Renewal

Kimura, W., Muralidhar, S. A., Canseco, D. C., Puente, B. N., Zhang, C. C., Xiao, F., Abderrahman, Y., & Sadek, H. A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6029 · Cited by 24

Stimulating endogenous cardiac repair

Finan, A., & Richard, S. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00057 · Cited by 23

Reviewing the Limitations of Adult Mammalian Cardiac Regeneration: Noncoding RNAs as Regulators of Cardiomyogenesis

Verjans, R., van Bilsen, M., & Schroen, B. L. M. (2020) · Biomolecules · doi:10.3390/biom10020262 · Cited by 24

Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure

Salama, A. B. M., Gebreil, A., Mohamed, T., & Abouleisa, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147720 · Cited by 23

MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States

Bailey, L. R. J., Bugg, D., Reichardt, I. M., Ortaç, C. D., Nagle, A., Gunaje, J. J., Martinson, A., Johnson, R. S., MacCoss, M. J., Sakamoto, T., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.066860 · Cited by 24

Cardiac fibroblasts in heart failure and regeneration

Harrington, A., & Moore‐Morris, T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1388378 · Cited by 25

Turning Back the Cardiac Regenerative Clock: Lessons From the Neonate

Mahmoud, A. I., & Porrello, E. R. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.07.008 · Cited by 23

Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway

Zhang, X., Ma, S., Zhang, R., Li, S., Zhu, D., Han, D. H., Li, X., Li, C., Yan, W., Sun, D., et al. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv137 · Cited by 24

Fish, the better model in human heart research? Zebrafish Heart aggregates as a 3D spontaneously cardiomyogenic in vitro model system

Hodgson, P., Ireland, J., & Grunow, B. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.04.009 · Cited by 23

Understanding the Metabolic Profile of Macrophages During the Regenerative Process in Zebrafish

Paredes, L. C., Câmara, N. O. S., & Braga, T. T. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00617 · Cited by 23

Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal

Chen, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062186 · Cited by 23

Cellular Reprogramming—A Model for Melanoma Cellular Plasticity

Granados, K., Poelchen, J., Novak, D., & Utikal, J. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218274 · Cited by 23

Low-Dose 6-Bromoindirubin-3′-oxime Induces Partial Dedifferentiation of Endothelial Cells to Promote Increased Neovascularization

Kohler, E. E., Baruah, J., Urao, N., Ushio‐Fukai, M., Fukai, T., Chatterjee, I., & Wary, K. K. (2014) · Stem Cells · doi:10.1002/stem.1658 · Cited by 22

Roles for noncoding RNAs in cell-fate determination and regeneration

Li, M., & Belmonte, J. C. I. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2946 · Cited by 22

From Ontogenesis to Regeneration

Chimenti, I., Forte, E., Angelini, F., Giacomello, A., & Messina, E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398459-3.00005-8 · Cited by 22

In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of cardiomyocyte proliferative potential

Cutie, S., Payumo, A. Y., Lunn, D., & Huang, G. N. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.04.013 · Cited by 22

Zebrafish Models of Cancer Therapy-Induced Cardiovascular Toxicity

Lane, S., More, L. A., & Asnani, A. H. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8020008 · Cited by 22

Cardiac cell type-specific responses to injury and contributions to heart regeneration

Zhang, W., Liang, J., & Han, P. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00065-1 · Cited by 23

Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial–Mesenchymal Transition-Like Response During Ventricle Regeneration

Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y., Li, X., Long, H., Xiong, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.632372 · Cited by 22

Cardiovascular Effects Mediated by HMMR and CD44

Jaskuła, K., Sacharczuk, M., Gaciong, Z. A., & Skiba, D. S. (2021) · Mediators of Inflammation · doi:10.1155/2021/4977209 · Cited by 22

Perfluorononanoate and Perfluorobutane Sulfonate Induce Cardiotoxic Effects in Zebrafish

Gong, H., Du, J., Xu, J. L., Yang, Y., Lü, H., & Xiao, H. (2022) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5447 · Cited by 22

Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis

Cho, K.-W., Andrade, M., Bae, S., Kim, S., Kim, J. E., Jang, E. Y., Lee, S., Husain, A., Sutliff, R. L., Calvert, J. W., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.061131 · Cited by 22

The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration

Goumenaki, P., Günther, S., Kikhi, K., Looso, M., Marín‐Juez, R., & Stainier, D. Y. R. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00538-5 · Cited by 22

Adult Stem Cells: From New Cell Sources to Changes in Methodology

Pelacho, B., Mazo, M. M., Gavira, J. J., & Prósper, F. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9245-z · Cited by 22

Micromechanical function of myofibrils isolated from skeletal and cardiac muscles of the zebrafish

Iorga, B. I., Neacsu, C. D., Neiss, W. F., Wagener, R., Paulsson, M., Stehle, R., & Pfitzer, G. (2011) · The Journal of General Physiology · doi:10.1085/jgp.201010568 · Cited by 22

An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation

Lim, C., Gandhi, S. K., Biniossek, M. L., Feng, L., Schilling, O., Urban, S., & Chen, X. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.001 · Cited by 22

Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes

Fan, X., Hughes, B. G., Ali, M. A., Chan, B. Y. H., Launier, K., & Schulz, R. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00229.2016 · Cited by 22

Dating the Heart: Exploring Cardiomyocyte Renewal in Humans

Graham, E. L., & Bergmann, O. (2016) · Physiology · doi:10.1152/physiol.00015.2016 · Cited by 22

Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine

Takata, N., & Eiraku, M. (2017) · Journal of Human Genetics · doi:10.1038/s10038-017-0348-0 · Cited by 23

The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

Yifa, O., Weisinger, K., Bassat, E., Li, H., Kain, D., Barr, H. M., Kozer, N., Genzelinakh, A., Rajchman, D., Eigler, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.128025 · Cited by 24

Stem cell therapies in cardiac diseases: Current status and future possibilities

Kasai-Brunswick, T. H., Carvalho, A. B., & de Carvalho, A. C. C. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i9.1231 · Cited by 22

Zebrafish models of cardiovascular diseases and their applications in herbal medicine research

Seto, S. W., Kiat, H., Lee, S. M., Bensoussan, A., Sun, Y., Hoi, M. P. M., & Chang, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.031 · Cited by 22

TCDD Inhibits Heart Regeneration in Adult Zebrafish

Hofsteen, P., Mehta, V., Kim, M., Peterson, R. E., & Heideman, W. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs329 · Cited by 22

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

Friedman, C. E., Cheetham, S. W., Negi, S., Mills, R. J., Ogawa, M., Redd, M. A., Chiu, H. S., Shen, S., Sun, Y., Mizikovsky, D., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.11.012 · Cited by 21

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

Bouwman, M., de Bakker, D. E. M., Honkoop, H., Giovou, A. E., Versteeg, D., Boender, A., Nguyen, P. D., Slotboom, M., Colquhoun, D., Vigil‐Garcia, M., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00588-9 · Cited by 21

The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish

Tahara, N., Akiyama, R., Wang, J., Kawakami, H., Bessho, Y., & Kawakami, Y. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.019 · Cited by 21

Postnatal state transition of cardiomyocyte as a primary step in heart maturation

Zheng, L., Yao, F., Peng, Y., Li, D., Zhang, M., Mao, L., Shen, X., Ren, Z., Wang, L., & Zhou, B. (2022) · Protein & Cell · doi:10.1007/s13238-022-00908-4 · Cited by 21

Cardiomyocyte maturation and its reversal during cardiac regeneration

Beisaw, A., & Wu, C. C. (2022) · Developmental Dynamics · doi:10.1002/dvdy.557 · Cited by 21

Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond

Huang, H., Huang, G. N., & Payumo, A. Y. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1629 · Cited by 21

Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture

Pieperhoff, S., Wilson, K. S., Baily, J. E., de Mora, K., Maqsood, S., Vass, S., Taylor, J. M., Del‐Pozo, J., MacRae, C. A., Mullins, J. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096771 · Cited by 21

Bone Marrow Therapies for Chronic Heart Disease

Behbahan, I. S., Keating, A., & Gale, R. P. (2015) · Stem Cells · doi:10.1002/stem.2080 · Cited by 21

Heart Regeneration in Adult Mammals after Myocardial Damage.

Cui, B., Zheng, Y., Sun, L., Shi, T., Shi, Z., Wang, L., Huang, G., & Sun, N. (2018) · PubMed Central · doi:10.6515/acs.201803_34(2).20171206a · Cited by 21

Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program

Yu, J. K., Sarathchandra, P., Chester, A. H., Yacoub, M. H., Brand, T., & Butcher, J. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-33994-8 · Cited by 21

Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration

Breus, O., & Dickmeis, T. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0269 · Cited by 21

Endocrine Influence on Cardiac Metabolism in Development and Regeneration

Graham, N., & Huang, G. N. (2021) · Endocrinology · doi:10.1210/endocr/bqab081 · Cited by 21

Animal Models of Spinal Cord Injury

Sobolev, V. E., Sysoev, Y. I., V’yunova, T. V., & Евгеньевич, М. П. (2025) · Biomedicines · doi:10.3390/biomedicines13061427 · Cited by 20

IL-6 coaxes cellular dedifferentiation as a pro-regenerative intermediate that contributes to pericardial ADSC-induced cardiac repair

Zhu, H., Liu, X., Ding, Y., Tan, K., Ni, W., Ouyang, W., Tang, J., Ding, X., Zhao, J., Hao, Y., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02675-1 · Cited by 19

Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

Peters, M. M. C., Martino, S. D., Boelens, T., Qin, J., van Mil, A., Doevendans, P. A., Chamuleau, S. A. J., Sluijter, J. P. G., & Neef, K. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.02.005 · Cited by 23

Extracellular Matrix-Based Approaches in Cardiac Regeneration: Challenges and Opportunities

Vu, T. V. A., Lorizio, D., Vuerich, R., Lippi, M., Nascimento, D. S., & Zacchigna, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415783 · Cited by 20

Autophagy in Tissue Repair and Regeneration

Moreno-Blas, D., Adell, T., & González‐Estévez, C. (2025) · Cells · doi:10.3390/cells14040282 · Cited by 22

Medicinal Chemistry Approaches to Heart Regeneration

Schade, D., & Plowright, A. T. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00446 · Cited by 21

Heart repair: from natural mechanisms of cardiomyocyte production to the design of new cardiac therapies

Martı́n-Puig, S., Fuster, V., & Torres, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06488.x · Cited by 20

Dynamics of Zebrafish Heart Regeneration Using an HPLC–ESI–MS/MS Approach

Ma, D., Tu, C., Sheng, Q., Yang, Y., Kan, Z., Guo, Y. P., Shyr, Y., Scott, I. C., & Lou, X. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00915 · Cited by 20

Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration

Klett, H., Jürgensen, L., Most, P., Busch, M., Günther, F., Dobreva, G. D., Leuschner, F., Hassel, D., Busch, H. S., & Boerries, M. (2018) · Biomolecules · doi:10.3390/biom9010011 · Cited by 20

Interventions in WNT Signaling to Induce Cardiomyocyte Proliferation: Crosstalk with Other Pathways

Blankesteijn, W. M. (2019) · Molecular Pharmacology · doi:10.1124/mol.119.118018 · Cited by 20

Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals

de Wit, L. H. C., Fang, J., Neef, K., Xiao, J., Doevendans, P. A., Schiffelers, R. M., Lei, Z., & Sluijter, J. P. G. (2020) · Biomolecules · doi:10.3390/biom10091204 · Cited by 20

The TGFβ superfamily in cardiac dysfunction

Wu, J., Jackson‐Weaver, O., & Xu, J. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy007 · Cited by 19

Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration

Martin, M., Gähwiler, E. K. N., Generali, M., Hoerstrup, S. P., & Emmert, M. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065188 · Cited by 19

Dedifferentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development in Mice

Arolkar, G., Sneha, K., Wang, H., Gonzalez, K. M., Kumar, S., Bishnoi, B., Coronado, P. E. R., Woo, Y.-P. J., Red‐Horse, K., & Das, S. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319319 · Cited by 19

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

Xiao, F., Nguyen, N. U. N., Wang, P., Li, S., Hsu, C., Thet, S., Kimura, W., Luo, X., Lam, N. T., Menendez-Montes, I., et al. (2024) · Circulation · doi:10.1161/circulationaha.122.059102 · Cited by 19

Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals

Tomasso, A., Disela, V., Longaker, M. T., & Bartscherer, K. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102228 · Cited by 19

Regulation of microRNA during cardiomyocyte maturation in sheep

Morrison, J. L., Zhang, S., Tellam, R. L., Brooks, D. A., McMillen, I. C., Porrello, E. R., & Botting, K. J. (2015) · BMC Genomics · doi:10.1186/s12864-015-1693-z · Cited by 19

Myocardial regeneration of the failing heart

Akhmedov, A. T., & Marín-García, J. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9348-5 · Cited by 20

Regenerative responses after mild heart injuries for cardiomyocyte proliferation in zebrafish

Itou, J., Akiyama, R., Pehoski, S., Yu, X., Kawakami, H., & Kawakami, Y. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24171 · Cited by 19

Redox Regulation of Heart Regeneration: An Evolutionary Tradeoff

Elhelaly, W. M., Lam, N. T., Hamza, M., Xia, S., & Sadek, H. A. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00137 · Cited by 20

Pericytes and cardiac stem cells: Common features and peculiarities

Beltrami, A. P., & Madeddu, P. R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.023 · Cited by 19

Constitutive cardiomyocyte proliferation in the leopard gecko (Eublepharis macularius)

Jacyniak, K., & Vickaryous, M. K. (2018) · Journal of Morphology · doi:10.1002/jmor.20850 · Cited by 19

Cardiomyocyte nuclearity and ploidy: when is double trouble?

Landim-Vieira, M., Schipper, J. M., Pinto, J. R., & Chase, P. B. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09545-7 · Cited by 21

Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway

Peng, X., Fan, S., Tan, J. H., Zeng, Z., Su, M., Zhang, Y., Yang, M. W. O., Xia, L., Fan, X., Cai, W., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00323 · Cited by 19

The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase

She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K. S., Wong, J., et al. (2020) · Development · doi:10.1242/dev.190678 · Cited by 20

Zebra-Fishing for Regenerative Awakening in Mammals

Massoz, L., Dupont, M. A., & Manfroid, I. (2021) · Biomedicines · doi:10.3390/biomedicines9010065 · Cited by 20

High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins

Niksirat, H., Siino, V., Steinbach, C., & Levander, F. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00387 · Cited by 20

Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

Mellis, I. A., Edelstein, H. I., Truitt, R., Goyal, Y., Beck, L. E., Symmons, O., Dunagin, M. C., Linares-Saldana, R., Shah, P. P., Pérez-Bermejo, J. A., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.07.003 · Cited by 20

Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio

Singleman, C., & Holtzman, N. G. (2011) · Journal of Visualized Experiments · doi:10.3791/3165 · Cited by 19

Telomeres and telomerase in heart regeneration

Aix, E., Gallinat, A., & Flores, I. (2018) · Differentiation · doi:10.1016/j.diff.2018.01.003 · Cited by 19

Residual Diploidy in Polyploid Tissues: A Cellular State with Enhanced Proliferative Capacity for Tissue Regeneration?

Patterson, M., & Swift, S. K. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0193 · Cited by 20

FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice

Xia, J., Liu, K., Lin, X., Li, H.-J., Lin, J.-H., Li, L., Liang, C., Cao, Y., Wen, N., Liao, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57962-9 · Cited by 18

Myocardial regeneration in adriamycin cardiomyopathy by nuclear expression of GLP1 using ultrasound targeted microbubble destruction

Chen, S., Chen, J., Huang, P., Meng, X., Clayton, S., Shen, J., & Grayburn, P. A. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.038 · Cited by 18

Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration

Anderson, T., Mo, J., Gagarin, E., Sherwood, D., Blumenkrantz, M., Mao, E., Leon, G., Levitz, H., Chen, H.-J., Tseng, K.-C., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00329-9 · Cited by 18

Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts

Yamak, A., Temsah, R. M., Maharsy, W. M., Caron, S., Paradis, P., Aries, A., & Nemer, M. J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00250.2012 · Cited by 18

Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes

Xiao, Y., Gao, M.-M., Gao, L., Zhao, Y., Hong, Q., Li, Z., Yao, J., Cheng, H., & Zhou, R. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.07.020 · Cited by 18

Decoding the Heart through Next Generation Sequencing Approaches

Pawlak, M., Nieścierowicz, K., & Winata, C. L. (2018) · Genes · doi:10.3390/genes9060289 · Cited by 19

Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates

Palmquist‐Gomes, P., Pérez-Pomares, J. M., & Guadix, J. A. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9750-8 · Cited by 18

Nitrite Improves Heart Regeneration in Zebrafish

Rochon, E. R., Missinato, M. A., Xue, J., Tejero, J., Tsang, M., Gladwin, M. T., & Corti, P. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7687 · Cited by 18

Cardiac regeneration as an environmental adaptation

Sakaguchi, A., Nishiyama, C., & Kimura, W. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118623 · Cited by 19

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

Välimäki, M. J., Leigh, R. S., Kinnunen, S. M., March, A. R., de Sande, A. H., Kinnunen, M., Varjosalo, M. T., Heinäniemi, M., Kaynak, B. L., & Ruskoaho, H. J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02259-z · Cited by 18

Molecular regulation of myocardial proliferation and regeneration

Zheng, L., Du, J., Wang, Z., Zhou, Q., Zhu, X., & Xiong, J. (2021) · Cell Regeneration · doi:10.1186/s13619-021-00075-7 · Cited by 18

Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Alonaizan, R., & Carr, C. (2022) · Biochemical Society Transactions · doi:10.1042/bst20210231 · Cited by 18

The Toolbox for Conditional Zebrafish Cancer Models

Mayrhofer, M., & Mione, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-30654-4_2 · Cited by 18

A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration

Xiao, Q., Zhang, G., Wang, H., Chen, L., Lu, S., Pan, D., Liu, G., & Yang, Z. (2017) · Development · doi:10.1242/dev.147827 · Cited by 18

Non-coding RNAs in endothelial cell signalling and hypoxia during cardiac regeneration

Peters, M. M. C., Sampaio‐Pinto, V., & Martins, P. A. D. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.07.010 · Cited by 18

Intrathoracic Injection for the Study of Adult Zebrafish Heart

Bise, T., & Jaźwińska, A. (2019) · Journal of Visualized Experiments · doi:10.3791/59724 · Cited by 17

Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish

Bühler, A., Gahr, B. M., Park, D.-D., Bertozzi, A., Boos, A., Vasudevarao, M. D., Pott, A., Oswald, F., Kovall, R. A., Kühn, B., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009890 · Cited by 18

Targeting immunoregulation for cardiac regeneration

Li, R., Xiang, C., Li, Y., & Nie, Y. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.02.003 · Cited by 18

Regulation of chromatin organization during animal regeneration

Jia, X., Lin, W., & Wang, W. (2023) · Cell Regeneration · doi:10.1186/s13619-023-00162-x · Cited by 18

Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration

Fu, W., Liao, Q., Shi, Y., Liu, W., Ren, H., Xu, C., & Zeng, C. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.021 · Cited by 17

Exploring the Function of Epicardial Cells Beyond the Surface

Wong, D., Martinez, J., & Quijada, P. J. (2024) · Circulation Research · doi:10.1161/circresaha.124.321567 · Cited by 17

The drug-elicitable alternative splicing module for tunable vector expression in the heart

Chen, Z., Yang, L., Zhang, Y., Li, J., Yang, Y., Li, Y., Fan, L., Chen, W., Miao, L., Liu, J., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00665-7 · Cited by 17

The link between injury-induced stress and regenerative phenomena: A cellular and genetic synopsis

Erler, P., & Monaghan, J. R. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.021 · Cited by 18

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans, T., MacRae, C. A., Stainier, D. Y. R., & Poss, K. D. (2010) · Nature · doi:10.1038/nature08804 · Cited by 1,084

Zebrafish as a Model for Studying Cardiac Regeneration

Wu, C. C., & Weidinger, G. (2014) · Current Pathobiology Reports · doi:10.1007/s40139-014-0042-2 · Cited by 2

Cardiac Regeneration in Zebrafish

Wu, C. C., & Weidinger, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-27583-3_10

Signals for cardiomyocyte proliferation during zebrafish heart regeneration

Pronobis, M. I., & Poss, K. D. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.02.002 · Cited by 29

Cardiac Regeneration in the Zebrafish Model System

Poss, K. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381332-9.00040-2