The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth
Open accessAbstract
The development of multicellular organisms relies on the coordinated control of cell divisions leading to proper patterning and growth. The molecular mechanisms underlying pattern formation, particularly the regulation of formative cell divisions, remain poorly understood. In Arabidopsis, formative divisions generating the root ground tissue are controlled by SHORTROOT (SHR) and SCARECROW (SCR). Here we show, using cell-type-specific transcriptional effects of SHR and SCR combined with data from chromatin immunoprecipitation-based microarray experiments, that SHR regulates the spatiotemporal activation of specific genes involved in cell division. Coincident with the onset of a specific formative division, SHR and SCR directly activate a D-type cyclin; furthermore, altering the expression of this cyclin resulted in formative division defects. Our results indicate that proper pattern formation is achieved through transcriptional regulation of specific cell-cycle genes in a cell-type- and developmental-stage-specific context. Taken together, we provide evidence for a direct link between developmental regulators, specific components of the cell-cycle machinery and organ patterning.
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Cited by
Adventitious Roots and Lateral Roots: Similarities and Differences
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Self-citationCilia, M., Peter, K. A., Bereman, M. S., Howe, K., Fish, T., Smith, D., Gildow, F., MacCoss, M. J., Thannhauser, T. W., & Gray, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048177 · Cited by 35
Metadata
- Authors
- Sozzani, R., Cui, H., Moreno-Risueno, M. A., Busch, W., Van Norman, J. M., Vernoux, T., Brady, S. M., Dewitte, W., Murray, J. A. H., & Benfey, P. N.
- Venue
- Nature
- Published
- 2010-07
- Volume
- 466
- Issue
- 7302
- Pages
- 128-132
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2035575208
- Cited by
- 438
- References
- 37
- FWCI
- 37.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Sozzani, R., Cui, H., Moreno-Risueno, M. A., Busch, W., Van Norman, J. M., Vernoux, T., Brady, S. M., Dewitte, W., Murray, J. A. H., & Benfey, P. N. (2010). Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. Nature. https://doi.org/10.1038/nature09143
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