Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

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    Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Flávia Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Iván Izquierdo · 2021 · Neurobiology of Learning and Memory
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  8. Prevention and Early Intervention: PTSD Following Traumatic Events
    Suzanne C. Leaman, Megan C. Kearns, Barbara O. Rothbaum · 2013 · FOCUS The Journal of Lifelong Learning in Psychiatry
  9. Genetic Markers in Psychiatry
    Gordana Nedić Erjavec, Dubravka Švob Štrac, Lucija Tudor, Marcela Konjevod, Marina Šagud, Nela Pivac · 2019 · Advances in experimental medicine and biology
  10. Abuse and Delayed Brain Maturation in Girls: The Cost of Lagging Behind
    Anaïs F. Stenson, Tanja Jovanović · 2021 · American Journal of Psychiatry
  11. Regulation of behavioral responses to single prolonged stress in male and female rats: Role of PACAP
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  12. Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models
    Yusuke Shintani, Atsuko Hayata‐Takano, Ichiro Takasaki, Takashi Kurihara, Atsuro Miyata, Yui Yamano, Manato Ikuta, Rei Takeshita, Kenichiro Murata, Taisei Oguri et al. · 2025 · Molecular Psychiatry
  13. Biomarkers of Traumatic Injury
    Cameron B. Jeter, John B. Redell, Anthony N. Moore, Georgene W. Hergenroeder, Jing Zhao, Daniel R. Johnson, Michael J. Hylin, Pramod K. Dash · 2011 · Springer eBooks
  14. PTSD biomarkers: Neuroendocrine signaling to epigenetic variants
    Alyssa M. Sbisa, Kristin Graham, Ellie Lawrence‐Wood, ALEXANDER COWELL McFARLANE, Catherine G. Toben · 2024 · Advances in clinical chemistry
  15. From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer’s disease treatment
    Artur Galushkin, Illana Gozes · 2024 · Current Research in Biotechnology
  16. Transgenerational Effects of PTSD or Traumatic Stress: Do Telomeres Reach Across the Generations?
    Burri A Maercker A · 2014 · Journal of Trauma & Treatment
  17. Post-traumatic Stress Disorder and DNA Methylation
    Jennifer A. Rusiecki, Monica Uddin, Melannie S. Alexander, Lee E. Moore · 2015 · Springer eBooks
  18. Cinsel İstismar Mağduru Kompleks Travma Sonrası Stres Bozukluğu olan Kız Ergenlerde Grup EMDR Uygulaması
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  19. The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms—A longitudinal analysis
    Jingyi Zhang, Gen Li, Haibo Yang, Chengqi Cao, Ruojiao Fang, Ping Liu, Shu Luo, Guangyi Zhao, Yingqian Zhang, Kunlin Zhang et al. · 2022 · Frontiers in Psychiatry
  20. Does age matter in genetics? The role of ADCYAP1R1 in sex-specific risk for posttraumatic stress disorder in trauma-exposed preadolescent children
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  21. PACAP Modulates Distinct Neuronal Components to Induce Cell-Specific Plasticity at Central and Autonomic Synapses
    Eric R. Starr, Joseph F. Margiotta · 2016 · Current topics in neurotoxicity
  22. Mechanisms of PACAP in PTSD and Stress-Related Disorders in Humans
    Lauren A. M. Lebois, Kerry James Ressler · 2016 · Current topics in neurotoxicity
  23. Epigenetics of Psychopathology
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  24. Prevalence and Predictors of Posttraumatic Stress Disorder Among Chinese Youths After an Earthquake
    Yue Wei, Li Wang, Richu Wang, Chengqi Cao, Zhanbiao Shi, Jianxin Zhang · 2013 · Social Behavior and Personality An International Journal
  25. Intergenerational Effects of PTSD on Offspring Glucocorticoid Receptor Methylation
    Mallory E. Bowers, Rachel Yehuda · 2016 · Epigenetics and human health
  26. Increased PACAP- and DβH-Positive Hepatic Nerve Fibers after Bisphenol A Exposure
    Michael Allen Thoene, Liliana Rytel, Ewa Dzika, Joanna Wojtkiewicz · 2021 · Toxics
  27. Neurogenetics Approaches to Mapping Pathways in Developmental Psychopathology
    Luke Williamson Hyde, Johnna R. Swartz, Rebecca E. Waller, Ahmad R. Hariri · 2016 · Wiley eBooks
  28. Integrative single-cell characterization of hypothalamus sex-differential and obesity-associated genes and regulatory elements
    Hai P. Nguyen, Candace S. Y. Chan, Dianne Laboy Cintrón, Rory R. Sheng, Lana Harshman, Mai Nobuhara, Aki Ushiki, Cassidy Biellak, Kelly An, Gracie Gordon et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Epigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders
    Fabien Boulle · 2013 · Research Publications (Maastricht University)
  30. Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing
    Jessica J. Lu, Giuseppe Deganutti, Miaomiao Li, Laura J. Humphrys, Yandi Li, Theodore J. Nettleton, Hariprasad Venugopal, Villy Julita, George Christopoulos, Christopher Arthur Reynolds et al. · 2025 · Proceedings of the National Academy of Sciences
  31. Bed Nucleus of the Stria Terminalis PACAP Signaling in the Dorsal Medial Habenula Mediates Depression-Related Behavioral Responses After Chronic Stress
    Nicholas R. Fontaine, Lauren Lepeak, Mahafuza Aktar, Aimee Mahler, William Black, Jens Hannibal, Margaret A. Vizzard, Víctor May, Sayamwong E. Hammack · 2025 · Biological Psychiatry
  32. The interface between the homeostatic and hedonic energy balance circuitries in the regulation of appetitive behavior: A focus on steroidogenic factor-1/pituitary adenylate cyclase-activating polypeptide neurons in the hypothalamic ventromedial nucleus
    Christopher Phan, Edward J. Wagner · 2025 · Neuroscience
  33. Estradiol and Sex Differences in Generalized Fear
    Jordan M. Adkins, Aaron M. Jasnow, Joseph F. Lynch · 2020 · Oxford University Press eBooks
  34. PACAP a mediator of inflammation following trauma exposure and mild traumatic brain injury: Differential effects in males and females
    Shane W. Adams, Aoife O’Donovan, Thomas C. Neylan, Víctor May, Sayamwong E. Hammack, Kerry James Ressler, Odette A. Harris, Sabra S. Inslicht · 2025 · Brain Behavior and Immunity
  35. Cartilage degradation is followed by PAC1 receptor reduction in articular cartilage of human knee joints
    Kálmán Racz, Yonatan Segal, Kinga Lénárt, Csaba Fillér, Anna Tóth, Vince Szegeczki, Péter Attila Gergely, Róza Zákány, Dóra Reglődi, Tamás Juhász · 2025 · GeroScience
  36. The vestibulocochlear bases for wartime posttraumatic stress disorder manifestations
    Teodoro A. Tigno, Rocco Anthony Armonda, Randy Scott Bell, Meryl A. Severson · 2017 · Medical Hypotheses
  37. The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli
    Daniel Porta Casteràs, Marta Cano, Trevor Steward, Raül Andero, Narcı́s Cardoner · 2022 · Neurobiology of Stress
  38. Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume
    Yukio Ago, Christina Van, Michael C. Condro, Haley Hrncir, Anna L. Diep, Abha Karki Rajbhandari, Michael S. Fanselow, Hitoshi Hashimoto, Allan J. MacKenzie‐Graham, James A. Waschek · 2023 · Experimental Neurology
  39. Partial Quantile Tensor Regression
    Dayu Sun, Limin Peng, Zhiping Qiu, Ying Guo, Amita K. Manatunga · 2024 · Journal of the American Statistical Association
  40. Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms
    Antonia V. Seligowski, Kevin J. Clancy, Eylül Akman, Michael William Lewis, Víctor May, Caitlin T. Ravichandran, Sydney A. Jobson, Daniel E. Bradford, Sayamwong E. Hammack, William A. Carlezon et al. · 2025 · Journal of Mood and Anxiety Disorders
  41. Integrated Approaches for Treatment-Resistant Psychiatric Disorders
    Seon‐Cheol Park, Yong‐Ku Kim · 2018 · Springer eBooks
  42. Epigenetics, Gender, and Sex in the Diagnosis of Depression
    Lewis Mehl‐Madrona, Patrick S. McFarlane, Barbara Mainguy · 2019 · Current Psychiatry Research and Reviews
  43. Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals
    Vinogran Naidoo, Olaia A. Martínez-Iglesias, Ramón Cacabelos · 2022 · Elsevier eBooks
  44. A PACAP-activated network for secretion requires coordination of Ca 2+ influx and Ca 2+ mobilization
    Xiaohuan Chen, Nicole A. Bell, Breanna L. Coffman, Agustín Rabino, Rafael García‐Mata, Paul J. Kammermeier, David I. Yule, Daniel Axelrod, Alan V. Smrcka, David R. Giovannucci et al. · 2024 · Molecular Biology of the Cell
  45. Posttraumatic Stress Disorder, Substance Abuse, and Other Behavioral Health Indicators among Active Duty Military Men and Women
    Laurel Lockwood Hourani · 2014 · Journal of Traumatic Stress Disorders & Treatment
  46. Sniffing Out a Role for PACAP in the Olfactory System
    Mary T. Lucero · 2016 · Current topics in neurotoxicity
  47. Investigation of pituitary adenylate cyclase activating polypeptide (PACAP) in human amniotic fluid samples
    Dénes Tóth, Béla Veszprémi, Miklós Koppán, Andrea Tamás, Donat Szogyi, Réka Brubel, József Németh, Mahsa Shams, Dóra Reglődi · 2020 · Reproductive Biology
  48. The predictors and outcome of psychiatric disorders among survivors post-earthquake: survey from Sichuan China
    Dongling Liu, Xiaolian Jiang, Samantha Pang, Sijian Li · 2014 · Australian journal of advanced nursing
  49. Post-Traumatic Stress Disorder and DNA Methylation
    Jennifer A. Rusiecki, Monica Uddin, Melannie S. Alexander, Lee E. Moore · 2016 · Springer eBooks
  50. It’s in the Genes: A New Marker for Sex Differences in Depression and Anxiety
    María M. Diehl · 2017 · Biological Psychiatry
  51. Activity-dependent neuroprotective protein (ADNP)/NAP (CP201): Autism, schizophrenia, and Alzheimer’s disease
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  52. Pituitary adenylate cyclase-activating polypeptide (PACAP) in stress, pain, and learning
    Nicole C. Ferrara, Marieke R. Gilmartin · 2020 · Handbook of behavioral neuroscience
  53. Trauma‐ and Stressor‐Related Disorders: Posttraumatic Stress Disorder, Acute Stress Disorder, and Adjustment Disorder
    Jessica Jade Fulton, Patrick S. Calhoun, Jean C. Beckham · 2015 · Wiley eBooks
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    Qi Zhang, Yang Han, Jacqueline C. K. Lam, Ruiqiao Bai, Illana Gozes, Victor O. K. Li · 2023 · medRxiv
  55. The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in women with no trauma/low trauma
    Eric Raúl Velasco, Jaime F. Nabás, David Torrents‐Rodas, Bárbara Arias, Rafael Torrúbia, Miquel Angel Fullana, Raül Andero · 2024 · Biological Psychology
  56. Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles
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  57. A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo
    Gwendolyn Shingles, Qianqian Pang, Jian Weng, Ryan Singer, Waleed Babar, Jiaqi Shen, Luis Vazquez-Rivera, Yao Chen, Peng Li, Wenjing Wang · 2026 · Proceedings of the National Academy of Sciences
  58. The ventral hippocampus to paraventricular thalamus circuit regulates context-dependent hyperlocomotion through PAC1 receptor signaling in the chronic stress-induced PTSD mouse model
    Zhiping Cao, Haiyan Gao, Binliang Tang, Yong Ji Xu · 2026 · Translational Psychiatry
  59. Frequent lineage-specific substitution rate changes support an episodic model for protein evolution
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  60. Az adenilát-cikláz-aktiváló polipeptid (PACAP) klinikai jelentősége
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  61. Sex Differences in Anxiety Disorders: Gonadal Hormone Interactions with Pathophysiology, Neurobiology, and Treatment
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  64. Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
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  65. Powerful and Efficient Strategies for Genetic Association Testing of Symptom and Questionnaire Data in Psychiatric Genetic Studies
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  67. Computational analysis of deleterious single nucleotide polymorphisms in catechol O-Methyltransferase conferring risk to post-traumatic stress disorder
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  68. Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder
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  69. Functional Chemoanatomy of PACAP in Neuroendocrine and Neuronal Circuits
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  70. Anxiety disorders
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  71. Mindfulness-Based Stretching and Deep Breathing Exercises Normalize Serum Cortisol Levels and Reverse Symptoms of PTSD: A Prospective Randomized-Controlled Trial
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  72. Trauma- and Stressor-Related Disorders
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  73. How and why does the pharmaceutical management of PTSD differ between men and women?
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  74. Genomics of PTSD
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  75. Corticotropin-Releasing Hormone Signaling in the Oval Bed Nucleus of the Stria Terminalis Mediates Chronic Stress-Induced Negative Valence Behaviors Associated with Anxiety
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  76. PACAP-mediated gating of anxiety-controlling circuits
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  77. Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility
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  92. HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment
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  95. Frequency and impact of post-traumatic stress disorder and traumatic life events in patients with migraine
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  100. Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach
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