The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex
Open accessAbstract
Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice. Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3β, whereas specific phosphorylation at serine 710 (S710) triggers the recruitment of Bardet–Biedl syndrome (BBS) proteins to the centrosome. In support of this model, loss of BBS1 leads to defects in migration, but not proliferation, whereas DISC1 knockdown leads to deficits in both. A phospho-dead mutant can only rescue proliferation, whereas a phospho-mimic mutant rescues exclusively migration defects. These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch.
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Cites
The cell biology of neurogenesis
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Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
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Cell-cycle control and cortical development
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Trekking across the Brain: The Journey of Neuronal Migration
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Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain
Duan, X., Chang, J. H., Ge, S., Faulkner, R. L., Kim, J. Y., Kitabatake, Y., Liu, X.-B., Yang, C.-H., Jordan, J. D., Ma, D. K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.010 · Cited by 611
Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
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Self-citationThe determination of projection neuron identity in the developing cerebral cortex
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Cited by
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon, N. J., & Sawa, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3120 · Cited by 428
Self-citationBarry, G., Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Ratnu, V. S., Nayler, S. P., Nones, K., Hu, J., Bredy, T. W., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.45 · Cited by 394
Ayalew, M., Le-Niculescu, H., Levey, D. F., Jain, N., Changala, B., Patel, S. D., Winiger, E., Breier, A., Shekhar, A., Amdur, R., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.37 · Cited by 397
Adolescent Stress–Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids
Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N. G., Kano, S.-I., Ozaki, N., Nabeshima, T., et al. (2013) · Science · doi:10.1126/science.1226931 · Cited by 318
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Metadata
- Authors
- Ishizuka, K., Kamiya, A., Oh, E. C., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K.-I., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M. D., Katsanis, N., & Sawa, A.
- Venue
- Nature
- Published
- 2011-04-06
- Volume
- 473
- Issue
- 7345
- Pages
- 92-96
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2128979893
- Cited by
- 198
- References
- 8
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Ishizuka, K., Kamiya, A., Oh, E. C., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K.-I., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M. D., Katsanis, N., & Sawa, A. (2011). DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. https://doi.org/10.1038/nature09859
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