The microcosmos of cancer
Open accessAbstract
The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.
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Recent studies have added numerous miRNAs to the gene constellation that p53 regulates, which contribute to its activation.
“Recent studies have added numerous miRNAs to the gene constellation that p53 regulates48,49, which in turn contribute to its activation.”
From MDM2, MDMX and p53 in oncogenesis and cancer therapy (2013) · cites this paper as [49]
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References 102 · Cited by 1,084
- Authors
- Lujambio, A., & Lowe, S. W.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Lowe, Scott W.
- Venue
- Nature
- Published
- 2012-02
- Volume
- 482
- Issue
- 7385
- Pages
- 347-355
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3509753
- OpenAlex
- W2148929244
- Cited by
- 1,084
- References
- 102
- Citations by year
- 2026: 15 · 2025: 36 · 2024: 44 · 2023: 49 · 2022: 58 · 2021: 54 · 2020: 81 · 2019: 78 · 2018: 95 · 2017: 95 · 2016: 100 · 2015: 124 · 2014: 110 · 2013: 108 · 2012: 37
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (R01AG016379)
- National Cancer Institute (P01CA013106, P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- microRNA, non-coding RNA, gene expression regulation, cancer, oncogenes, tumour suppressor, microRNA dysregulation, cancer therapeutics, therapeutic target
- MeSH terms
- Animals, Humans, Neoplasm Metastasis, Neoplasms, Oncogenes, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, MicroRNAs
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