The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development
Open accessAbstract
How environmental cues regulate adult stem cell and cancer cell activity through surface receptors is poorly understood. Angiopoietin-like proteins (ANGPTLs), a family of seven secreted glycoproteins, are known to support the activity of haematopoietic stem cells (HSCs) in vitro and in vivo. ANGPTLs also have important roles in lipid metabolism, angiogenesis and inflammation, but were considered ‘orphan ligands’ because no receptors were identified. Here we show that the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue paired immunoglobulin-like receptor (PIRB) are receptors for several ANGPTLs. LILRB2 and PIRB are expressed on human and mouse HSCs, respectively, and the binding of ANGPTLs to these receptors supported ex vivo expansion of HSCs. In mouse transplantation acute myeloid leukaemia models, a deficiency in intracellular signalling of PIRB resulted in increased differentiation of leukaemia cells, revealing that PIRB supports leukaemia development. Our study indicates an unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development.
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Cites
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“The manufacturers and catalogue numbers for other antibodies are as follows: anti-LILRB1, Biolegend (33707); anti-LILRB2, eBioscience (125149); anti-LILRB3, eBioscience (12-5159); anti-LILRB4, eBiosciene (12-5139); anti-LILRB5, R&D Systems (AF3065); anti-PIRB–PE, R&D Systems (FAB2754P); anti-human LAIR1–PE, BD Pharmin…”
BackgroundSimsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101
Self-citationIdentification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
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PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration
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PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
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Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
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Phagocytosis checkpoints as new targets for cancer immunotherapy
Feng, M., Jiang, W., Kim, B. Y. S., Zhang, C. C., Fu, Y.-X., & Weissman, I. L. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0183-z · Cited by 911
Self-citationKim, T., Vidal, G. S., Djurisic, M., William, C. M., Birnbaum, M. E., Garcia, K. C., Hyman, B. T., & Shatz, C. J. (2013) · Science · doi:10.1126/science.1242077 · Cited by 410
Carosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
Medyouf, H., Mossner, M., Jann, J.-C., Nolte, F., Raffel, S., Herrmann, C., Lier, A., Eisen, C., Nowak, V., Zens, B., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.02.014 · Cited by 388
Metadata
- Authors
- Zheng, J., Umikawa, M., Cui, C., Li, J., Chen, X., Zhang, C., Huynh, H., Kang, X., Silvany, R., Wan, X., Ye, J., Cantó, A. P., Chen, S.-H., Wang, H.-Y., Ward, E. S., & Zhang, C. C.
- Venue
- Nature
- Published
- 2012-05-30
- Volume
- 485
- Issue
- 7400
- Pages
- 656-660
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2049489460
- Cited by
- 275
- References
- 35
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, J., Umikawa, M., Cui, C., Li, J., Chen, X., Zhang, C., Huynh, H., Kang, X., Silvany, R., Wan, X., Ye, J., Cantó, A. P., Chen, S.-H., Wang, H.-Y., Ward, E. S., & Zhang, C. C. (2012). Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. https://doi.org/10.1038/nature11095
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