Dissecting the genomic complexity underlying medulloblastoma

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Items 301–400 of 852

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2. Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33
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5. Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies
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6. Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
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7. The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target
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8. Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022
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9. Genetic and molecular alterations across medulloblastoma subgroups
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10. Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma
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11. Genomic and Epigenomic Landscape in Meningioma
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12. Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy
    Nagendra K. Chaturvedi, Matthew J. Kling, Donald W. Coulter, Timothy R. McGuire, Sutapa Ray, Varun Kesherwani, Shantaram S. Joshi, John Graham Sharp · 2018 · Oncotarget
13. MRI features as a helpful tool to predict the molecular subgroups of medulloblastoma: state of the art
    Giovanna Stefania Colafati, Ioan Paul Voicu, Chiara Carducci, Evelina Miele, Andrea Carai, Simona Di Loreto, Antonio Marrazzo, Antonella Cacchione, Valerio Cecinati, Assunta Tornesello et al. · 2018 · Therapeutic Advances in Neurological Disorders
14. Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
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15. Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization
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16. Targeting BRD9 for Cancer Treatment: A New Strategy
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17. Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis
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18. Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma
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19. Embryonal Tumors of the Central Nervous System in Children: The Era of Targeted Therapeutics
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20. Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors
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21. Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack
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22. Identification of a neuronal transcription factor network involved in medulloblastoma development
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23. Future of Clinical Genomics in Pediatric Oncology
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24. Demographics, patterns of care, and survival in pediatric medulloblastoma
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25. Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis
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26. SETD2 mutations in primary central nervous system tumors
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27. Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy
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28. Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors
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29. Planarian flatworms as a new model system for understanding the epigenetic regulation of stem cell pluripotency and differentiation
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30. Identification and Characterization of Cancer Mutations in Japanese Lung Adenocarcinoma without Sequencing of Normal Tissue Counterparts
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31. The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture
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32. UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes
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33. Principles of tumorigenesis and emerging molecular drivers of SHH ‐activated medulloblastomas
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34. Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors’ Cancer Stem Cells: Current Knowledge and Future Perspectives
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35. Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development
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36. The evolution of medulloblastoma therapy to personalized medicine
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37. Pediatric Brain Tumors
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38. Subgroup-Specific Diagnostic, Prognostic, and Predictive Markers Influencing Pediatric Medulloblastoma Treatment
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39. Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer
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40. MED 12 mutations and NOTCH signalling in chronic lymphocytic leukaemia
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41. Medulloblastoma: recurrence and metastasis
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42. Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics
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43. Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
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44. Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential
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45. Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer
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46. Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells
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47. Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy
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48. The Updated World Health Organization Glioma Classification: Cellular and Molecular Origins of Adult Infiltrating Gliomas
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49. Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma
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50. The use of amnion-derived cellular cytokine solution to improve healing in acute and chronic wound models.
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58. Fluorescence Lifetime Imaging Microscopy, a Novel Diagnostic Tool for Metastatic Cell Detection in the Cerebrospinal Fluid of Children with Medulloblastoma
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59. Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence
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60. Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development
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61. The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas
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62. Casein Kinase 1δ Is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis
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63. Primary cilia control translation and the cell cycle in medulloblastoma
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64. Molecular and clinical heterogeneity within MYC -family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study
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65. RNA Binding Protein-Mediated Post-Transcriptional Gene Regulation in Medulloblastoma
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68. Medulloblastoma in the Molecular Era
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69. Genomic sequencing in cancer
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70. The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
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71. Genetic alterations related to BRAF‐FGFR genes and dysregulated MAPK/ERK /m TOR signaling in adult pilocytic astrocytoma
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72. The role of stem cells and progenitors in the genesis of medulloblastoma
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73. Notch1 -Induced Brain Tumor Models the Sonic Hedgehog Subgroup of Human Medulloblastoma
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74. Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation
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75. Next Generation Protein Structure Predictions and Genetic Variant Interpretation
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76. Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma
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77. Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study*
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79. Deregulated proliferation and differentiation in brain tumors
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80. Pediatric high-grade astrocytomas: a distinct neuro-oncological paradigm
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81. Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation
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82. Hedgehog signaling pathway as a therapeutic target for ovarian cancer
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83. Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream
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84. Genomic features of renal cell carcinoma with venous tumor thrombus
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85. Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
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86. DDX3X-MLLT10 fusion in adults with NOTCH1 positive T-cell acute lymphoblastic leukemia
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88. Mutations of Chromatin Structure Regulating Genes in Human Malignancies
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97. Targeting of histone deacetylases in brain tumors
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98. Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a Time
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99. Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation
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