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Integration of chemical catalysis with extractive fermentation to produce fuels
Abstract
Nearly one hundred years ago, the fermentative production of acetone by Clostridium acetobutylicum provided a crucial alternative source of this solvent for manufacture of the explosive cordite. Today there is a resurgence of interest in solventogenic Clostridium species to produce n-butanol and ethanol for use as renewable alternative transportation fuels. Acetone, a product of acetone-n-butanol-ethanol (ABE) fermentation, harbours a nucleophilic α-carbon, which is amenable to C-C bond formation with the electrophilic alcohols produced in ABE fermentation. This functionality can be used to form higher-molecular-mass hydrocarbons similar to those found in current jet and diesel fuels. Here we describe the integration of biological and chemocatalytic routes to convert ABE fermentation products efficiently into ketones by a palladium-catalysed alkylation. Tuning of the reaction conditions permits the production of either petrol or jet and diesel precursors. Glyceryl tributyrate was used for the in situ selective extraction of both acetone and alcohols to enable the simple integration of ABE fermentation and chemical catalysis, while reducing the energy demand of the overall process. This process provides a means to selectively produce petrol, jet and diesel blend stocks from lignocellulosic and cane sugars at yields near their theoretical maxima.
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“Another promising approach to convert ethanol (and other short-chain alcohols) to jet (or biodiesel) fuels is via extractive catalytic upgrading directly from the fermentation broth (Anbarasan et al., 2012; Bormann et al., 2014; Sreekumar et al., 2014, 2015; Baer et al., 2016).”
From Gas Fermentation—A Flexible Platform for Commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks (2016) · cites this paper as Anbarasan et al., 2012
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Metadata
- Authors
- Anbarasan, P., Baer, Z. C., Sreekumar, S., Gross, E., Binder, J. B., Blanch, H. W., Clark, D. S., & Toste, F. D.
- Affiliations
- Energy Biosciences Institute (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Toste, F. Dean
- Venue
- Nature
- Published
- 2012-11-07
- Volume
- 491
- Issue
- 7423
- Pages
- 235-239
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1995815598
- Cited by
- 385
- References
- 28
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 21 · 2023: 22 · 2022: 29 · 2021: 24 · 2020: 26 · 2019: 32 · 2018: 30 · 2017: 36 · 2016: 56 · 2015: 33 · 2014: 26 · 2013: 21 · 2012: 1
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Catalysis for Biomass Conversion
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- acetone-butanol-ethanol fermentation, ketone production, biofuels, jet fuel precursors, Clostridium acetobutylicum, lignocellulosic biomass, cane sugar, C–C bond formation, renewable transportation fuels
- MeSH terms
- Acetone, Ethanol, Alkylation, Catalysis, Fermentation, Gasoline, Ketones, Lignin, Models, Chemical, Palladium, Time Factors, Triglycerides, Biomass, 1-Butanol, Saccharum, Clostridium acetobutylicum, Biofuels
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