orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET

Cited by (474)

Items 101–200 of 474

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    Lisa Soyeon Baik, John R. Carlson · 2020 · Proceedings of the National Academy of Sciences
  4. BiteOscope, an open platform to study mosquito biting behavior
    Felix J.H. Hol, Louis Lambrechts, Manu Prakash · 2020 · eLife
  5. Fruitless mutant male mosquitoes gain attraction to human odor
    Nipun S. Basrur, Maria Elena De Obaldia, Takeshi Morita, Margaret Herre, Ricarda K. von Heynitz, Yael N. Tsitohay, Leslie B. Vosshall · 2020 · eLife
  6. Ir76b is a Co-receptor for Amine Responses in Drosophila Olfactory Neurons
    Alina Vulpe, Pratyajit Mohapatra, Karen Menuz · 2021 · Frontiers in Cellular Neuroscience
  7. Recent Insights into Insect Olfactory Receptors and Odorant-Binding Proteins
    Tal Soo Ha, Dean P. Smith · 2022 · Insects
  8. A novel olfactory pathway is essential for fast and efficient blood-feeding in mosquitoes
    Je Won Jung, Seung-Jae Baeck, Haribalan Perumalsamy, Bill S. Hansson, Young‐Joon Ahn, Hyung Wook Kwon · 2015 · Scientific Reports
  9. Field Evaluation of Picaridin Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of Malaria and Arboviruses
    Karel J van Roey, Mao Sokny, Leen Denis, Nick Van den Broeck, Somony Heng, Siv Sovannaroth, Vincent Sluydts, Tho Sochantha, Marc Coosemans, Lies Durnez · 2014 · PLoS neglected tropical diseases
  10. Signaling Mode of the Broad-Spectrum Conserved CO2 Receptor Is One of the Important Determinants of Odor Valence in Drosophila
    Dyan MacWilliam, Joel Kowalewski, Arun Kumar, Crystal G. Pontrello, Anandasankar Ray · 2018 · Neuron
  11. Differential attraction in mosquito–human interactions and implications for disease control
    Julien Martinez, Alicia Showering, Catherine E. Oke, R. Gareth Jones, James G. Logan · 2020 · Philosophical Transactions of the Royal Society B Biological Sciences
  12. Discrete roles of Ir76b ionotropic coreceptor impact olfaction, blood feeding, and mating in the malaria vector mosquito Anopheles coluzzii
    Zi Ye, Feng Liu, Huahua Sun, Stephen T. Ferguson, Adam P. Baker, Samuel A. Ochieng, Laurence J. Zwiebel · 2022 · Proceedings of the National Academy of Sciences
  13. Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking
    Trias N. Thireou, Georgia Kythreoti, Katerina E. Tsitsanou, Konstantinos Koussis, Christina E. Drakou, Julie Kinnersley, Thomas Kröber, Patrick M. Guérin, Jing‐Jiang Zhou, Kostas Iatrou et al. · 2018 · Insect Biochemistry and Molecular Biology
  14. Prospects for malaria control through manipulation of mosquito larval habitats and olfactory-mediated behavioural responses using plant-derived compounds
    Jackson M. Muema, Joel Ltilitan Bargul, Sospeter Ngoci Njeru, Joab Otieno Onyango, Susan S Imbahale · 2017 · Parasites & Vectors
  15. Neurodevelopmental and transcriptomic effects of CRISPR/Cas9-induced somatic orco mutation in honey bees
    Zhenqing Chen, Ian M. Traniello, Seema Rana, Amy C. Cash-Ahmed, Alison L. Sankey, Che Yang, Gene E. Robinson · 2021 · Journal of Neurogenetics
  16. Human scent guides mosquito thermotaxis and host selection under naturalistic conditions
    Diego Giraldo, Stephanie Rankin‐Turner, Abel Corver, Genevieve M. Tauxe, Anne L. Gao, Dorian M. Jackson, Limonty Simubali, Christopher Book, Jennifer C. Stevenson, Philip E. Thuma et al. · 2023 · Current Biology
  17. Silencing the Olfactory Co-Receptor RferOrco Reduces the Response to Pheromones in the Red Palm Weevil, Rhynchophorus ferrugineus
    Alan Soffan, Binu Antony, Mahmoud M. Abdelazim, Paraj Shukla, Witjaksono Witjaksono, Saleh A. Aldosari, Abdulrahman S. Aldawood · 2016 · PLoS ONE
  18. Mosquito transgenesis for malaria control
    Shengzhang Dong, Yuemei Dong, Maria L. Simões, George Dimopoulos · 2021 · Trends in Parasitology
  19. A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
    Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih‐Che Weng, Brittney D Wick, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti et al. · 2025 · Cell
  20. Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact
    Jonathan Trevorrow Clark, Anandasankar Ray · 2016 · Journal of Chemical Ecology
  21. Silencing of the olfactory co-receptor gene in Dendroctonus armandi leads to EAG response declining to major host volatiles
    Ranran Zhang, Guanqun Gao, Hui Chen · 2016 · Scientific Reports
  22. Use of semiochemicals for surveillance and control of hematophagous insects
    Collins Kalwale Mweresa, Wolfgang Richard Mukabana, Joop J. A. van Loon, Marcel Dicke, Willem Takken · 2020 · Chemoecology
  23. Inhibition of Anopheles gambiae Odorant Receptor Function by Mosquito Repellents
    Panagiota Tsitoura, Konstantinos Koussis, Kostas Iatrou · 2015 · Journal of Biological Chemistry
  24. Silencing the odorant coreceptor (Orco) disrupts sex pheromonal communication and feeding responses in Blattella germanica: toward an alternative target for controlling insect‐transmitted human diseases
    Peng He, Yunfeng Ma, Mei‐Mei Wang, Hong Wang, Youssef Dewer, Nesreen M. Abd El-Ghany, Guang‐Lei Chen, Guiqing Yang, Fan Zhang, Ming He · 2020 · Pest Management Science
  25. Chemosensory gene expression in olfactory organs of the anthropophilic Anopheles coluzzii and zoophilic Anopheles quadriannulatus
    Giridhar Athrey, Luciano V. Cosme, Zachary R. Popkin-Hall, Sharmila Pathikonda, Willem Takken, Michel A. Slotman · 2017 · BMC Genomics
  26. Identification and phylogenetics of Spodoptera frugiperda chemosensory proteins based on antennal transcriptome data
    Lin Qiu, Li He, Xiaoping Tan, Zhengbing Zhang, Yong Wang, Xinwen Li, Hualiang He, Wenbing Ding, Youzhi Li · 2020 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
  27. A persistent behavioral state enables sustained predation of humans by mosquitoes
    Trevor R. Sorrells, Anjali Pandey, Adriana Rosas-Villegas, Leslie B. Vosshall · 2022 · eLife
  28. Divergent and Conserved Elements Comprise the Chemoreceptive Repertoire of the Nonblood-Feeding Mosquito Toxorhynchites amboinensis
    Xiaofan Zhou, David C. Rinker, Ronald Jason Pitts, Antonis Rokas, Laurence J. Zwiebel · 2014 · Genome Biology and Evolution
  29. Human Odour Coding in the Yellow Fever Mosquito, Aedes aegypti
    Zhou Chen, Feng Liu, Nannan Liu · 2019 · Scientific Reports
  30. Cross-modal sensory compensation increases mosquito attraction to humans
    Takeshi Morita, Nia G. Lyn, Ricarda K. von Heynitz, Olivia V. Goldman, Trevor R. Sorrells, Matthew DeGennaro, Benjamin John Matthews, Leah Houri-Zeevi, Leslie B. Vosshall · 2025 · Science Advances
  31. CRISPR‐mediated mutagenesis of the odorant receptor co‐receptor (Orco) gene disrupts olfaction‐mediated behaviors in Bactrocera dorsalis
    Li Xu, Hong‐Bo Jiang, Kai‐Yue Tang, Ying Yan, Marc F. Schetelig, Jin‐Jun Wang · 2022 · Insect Science
  32. Odorant-receptor-mediated regulation of chemosensory gene expression in the malaria mosquito Anopheles gambiae
    Sarah E. Maguire, Ali Afify, Loyal A. Goff, Christopher J. Potter · 2022 · Cell Reports
  33. Odor-mediated response of gravid Aedes aegypti to mosquito-associated symbiotic bacteria
    Katherine D. Mosquera, Zaid Khan, Betelehem Wondwosen, Beatrix Waechter Alsanius, Sharon R. Hill, Rickard Ignell, Marcelo Gustavo Lorenzo · 2022 · Acta Tropica
  34. The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells
    Samuel Legeay, Nicolas Clere, Grégory Hilairet, Quoc‐Tuan Do, Philippe Bernard, Jean‐François Quignard, Véronique Apaire-Marchais, Bruno Lapied, Sébastien Faure · 2016 · Scientific Reports
  35. Current status of genome editing in vector mosquitoes: A review
    Appadurai Daniel Reegan, Stanislaus Antony Ceasar, Michael Gabriel Paulraj, Savarimuthu Ignacimuthu S.J., Naïf Abdullah Al-Dhabi · 2016 · BioScience Trends
  36. An updated antennal lobe atlas for the yellow fever mosquito Aedes aegypti
    Shruti Shankar, Conor J. McMeniman · 2020 · PLoS neglected tropical diseases
  37. Diverse mechanisms of taste coding in Drosophila
    Hany K. M. Dweck, John R. Carlson · 2023 · Science Advances
  38. Targeted genome editing in Aedes aegypti using TALENs
    Azadeh Aryan, Kevin M. Myles, Zach N. Adelman · 2014 · Methods
  39. Age influences the olfactory profiles of the migratory oriental armyworm mythimna separate at the molecular level
    HE Yue-qiu, Bo Feng, Qianshuang Guo, Yongjun Du · 2017 · BMC Genomics
  40. Construction of an efficient genomic editing system with CRISPR/Cas9 in the vector mosquito Aedes albopictus
    Tong Liu, Wenqiang Yang, Yugu Xie, Pei‐Wen Liu, Lihua Xie, Feng Lin, Chen‐Ying Li, Jinbao Gu, Kun Wu, Guiyun Yan et al. · 2018 · Insect Science
  41. Transcriptome Surveys in Silverfish Suggest a Multistep Origin of the Insect Odorant Receptor Gene Family
    Michael Thoma, Christine Mißbach, Melissa D. Jordan, Ewald Große‐Wilde, Richard D. Newcomb, Bill S. Hansson · 2019 · Frontiers in Ecology and Evolution
  42. Silencing Orco Impaired the Ability to Perceive Trail Pheromones and Affected Locomotion Behavior in Two Termite Species
    Yongyong Gao, Qiuying Huang, Huan Xu · 2020 · Journal of Economic Entomology
  43. Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought
    2023
  44. Sodium channel activation underlies transfluthrin repellency in Aedes aegypti
    Andreazza, Felipe, Valbon, Wilson R., Wang, Qiang, Liu, Feng, Xu, Peng, Bandason, Elizabeth, Chen, Mengli, Wu, Shaoying, Smith, Leticia B., Scott, Jeffrey G. et al. · 2021 · PLOS Neglected Tropical Diseases
  45. Carbon Dioxide, Odorants, Heat and Visible Cues Affect Wild Mosquito Landing in Open Spaces
    Yang‐Hong Zhou, Zhong-Wei Zhang, Yu‐Fan Fu, Gongchang Zhang, Shu Yuan · 2018 · Frontiers in Behavioral Neuroscience
  46. Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee
    Julie Carcaud, Marianne Otte, Bernd Grünewald, Albrecht Haase, Jean‐Christophe Sandoz, Martin Beye · 2023 · PLoS Biology
  47. Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit
    Devin Kepchia, Pingxi Xu, Raymond Terryn, Ana Castro, Stephan C. Schürer, Walter S. Leal, Charles W. Luetje · 2019 · Scientific Reports
  48. Identification of Aedes aegypti cis-regulatory elements that promote gene expression in olfactory receptor neurons of distantly related dipteran insects
    Keshava Mysore, Ping Li, Molly Duman‐Scheel · 2018 · Parasites & Vectors
  49. Bdor ⧹ Orco is important for oviposition-deterring behavior induced by both the volatile and non-volatile repellents in Bactrocera dorsalis (Diptera: Tephritidae)
    Xin Yi, Haiming Zhao, Peidan Wang, Meiying Hu, Guohua Zhong · 2014 · Journal of Insect Physiology
  50. Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies
    Michelle Bui, Jennifer Shyong, Eleanor K. Lutz, Ting Yang, Ming Li, Kenneth Truong, Ryan S. Arvidson, Anna B. Buchman, Jeffrey A. Riffell, Omar S. Akbari · 2019 · BMC Neuroscience
  51. Mosquito Host-Seeking Regulation: Targets for Behavioral Control
    Laura B. Duvall · 2019 · Trends in Parasitology
  52. Membrane Proteins Mediating Reception and Transduction in Chemosensory Neurons in Mosquitoes
    Jackson T. Sparks, Gina Botsko, Daniel R. Swale, Linda M. Boland, Shriraj S. Patel, Joseph C. Dickens · 2018 · Frontiers in Physiology
  53. Molecular Profiling of theDrosophilaAntenna Reveals Conserved Genes Underlying Olfaction in Insects
    Pratyajit Mohapatra, Karen Menuz · 2019 · G3 Genes Genomes Genetics
  54. Novel Genetic and Molecular Tools for the Investigation and Control of Dengue Virus Transmission by Mosquitoes
    Alexander W. E. Franz, Rollie J. Clem, A. Lorena Passarelli · 2014 · Current Tropical Medicine Reports
  55. Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids
    Gwénaëlle Bontonou, Bastien Saint‐Leandre, Tane Kafle, Tess Baticle, Afrah Abood Hassan, Juan Antonio Sánchez‐Alcañiz, J. Roman Arguello · 2024 · Nature Communications
  56. The structure of Orco and its impact on our understanding of olfaction
    Frank Zufall, Ana Isabel Domingos · 2018 · The Journal of General Physiology
  57. A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans
    Emily Jane Dennis, May Dobosiewicz, Xin Jin, Laura B. Duvall, Philip S. Hartman, Cornelia I. Bargmann, Leslie B. Vosshall · 2018 · Nature
  58. Olfactory co‐receptor is involved in host recognition and oviposition in Ophraella communa (Coleoptera: Chrysomelidae)
    Chao Ma, Shaowei Cui, Qiang Bai, Zhenya Tian, Yan Zhang, Guangmei Chen, Xuyuan Gao, Zhenqi Tian, Hongsong Chen, Jianying Guo et al. · 2020 · Insect Molecular Biology
  59. Multiple channels of DEET repellency in Drosophila
    Hao Guo, Kishor Kunwar, Dean P. Smith · 2019 · Pest Management Science
  60. Ir40a neurons are not DEET detectors
    Ana F. Silbering, Rati Bell, Daniel Münch, Steeve Cruchet, Carolina Gomez‐Diaz, Thomas Laudes, C. Giovanni Galizia, Richard Benton · 2016 · Nature
  61. Volatile allosteric antagonists of mosquito odorant receptors inhibit human-host attraction
    Georgia Kythreoti, Nadia Sdralia, Panagiota Tsitoura, Dimitrios Papachristos, Αntonios Michaelakis, Vasileios Karras, David M. Ruel, Esther Yakir, Jonathan Daniel Bohbot, Stefan Schulz et al. · 2020 · Journal of Biological Chemistry
  62. Vitex negundo L. Essential Oil: Odorant Binding Protein Efficiency Using Molecular Docking Approach and Studies of the Mosquito Repellent
    Bamidele Joseph Okoli, Zakari Ladan, Fanyana M. Mtunzi, Y.C. Hosea · 2021 · Insects
  63. A spatial map of antennal-expressed ionotropic receptors in the malaria mosquito
    Joshua Ibukun Raji, Joanna K. Konopka, Christopher J. Potter · 2023 · Cell Reports
  64. Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
    Perran A. Ross, Meng‐Jia Lau, Ary A. Hoffmann · 2019 · PLoS ONE
  65. Chemoreceptor Co-Expression in Drosophila Olfactory Neurons
    Darya Task, Chun‐Chieh Lin, Alina Vulpe, Ali Afify, Sydney Ballou, Maria Brbić, Philipp Schlegel, Gregory S.X.E. Jefferis, Hongjie Li, Karen Menuz et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Disruption of the odorant coreceptor Orco impairs foraging and host finding behaviors in the New World screwworm fly
    Daniel Fernando Paulo, Ana Carolina M. Junqueira, Alex P. Arp, André Schwambach Vieira, Jorge A. Ceballos, S. Skoda, Adalberto Angel Pérez de León, Agustin Sagel, W. Owen McMillan, Maxwell J. Scott et al. · 2021 · Scientific Reports
  67. Bitter-sensitive gustatory receptor neuron responds to chemically diverse insect repellents in the common malaria mosquito Anopheles quadrimaculatus
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  68. Silencing the odorant receptor co-receptor impairs olfactory reception in a sensillum-specific manner in the cockroach
    Kosuke Tateishi, Takayuki Watanabe, Hiroshi Nishino, Makoto Mizunami, Hidehiro Watanabe · 2022 · iScience
  69. A critical review of current laboratory methods used to evaluate mosquito repellents
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  70. A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
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  93. Mutagenesis of odorant coreceptor Orco reveals the distinct role of olfaction between sexes in Spodoptera frugiperda
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  95. Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti
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  96. Green synthesis and biophysical characterization of silver and palladium nanoparticles using Laureliopsis philippiana: A potent eco-friendly larvicide with negligible impact on zebrafish (Danio rerio)
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  97. Plant based and synthetic products as mosquito repellents: effects, target sites and their mechanism of action on mosquitoes
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  98. Chemosensory Gene Families in the Oligophagous Pear Pest Cacopsylla chinensis (Hemiptera: Psyllidae)
    Ji-Wei Xu, Xiu‐Yun Zhu, Qiujie Chao, Yongjie Zhang, Yongjie Zhang, Yuxia Yang, Yu Zhang, Meng-Zhen Xie, Ya-Ting Ge, Xin-Lai Wu et al. · 2019 · Insects
  99. Bio efficacy of Cinnamaldehyde from Cinnamomum verum essential oil against Culex quinquefasciatus (Diptera: Culicidae)
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  100. Chemosensory ionotropic receptors in human host-seeking mosquitoes
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