In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

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Modes of resistance to anti-angiogenic therapy

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CRISPR/Cas, the Immune System of Bacteria and Archaea

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Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint

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SEMMs: Somatically Engineered Mouse Models. A New Tool for In Vivo Disease Modeling for Basic and Translational Research

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Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery

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Shifts in keratin isoform expression activate motility signals during wound healing

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Therapeutic application of the CRISPR system: current issues and new prospects

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New insights on CRISPR/Cas9-based therapy for breast Cancer

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Directed genome evolution driven by structural rearrangement techniques

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CRISPR/Cas9 in cancer therapy: A review with a special focus on tumor angiogenesis

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Tips, Tricks, and Potential Pitfalls of CRISPR Genome Editing in Saccharomyces cerevisiae

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Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

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Genome Editing of Structural Variations: Modeling and Gene Correction

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Generating Genetically Modified Mice: A Decision Guide

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Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy DevelopmentPreprint

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CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish

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Ligation-assisted homologous recombination enables precise genome editing by deploying both MMEJ and HDR

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CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements

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Mouse models for core binding factor leukemia

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Applications of CRISPR systems in respiratory health: Entering a new ‘red pen’ era in genome editing

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Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9

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Polyrotaxane Nanocarriers Can Deliver CRISPR/Cas9 Plasmid to Dystrophic Muscle Cells to Successfully Edit the DMD Gene

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Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models

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GUK1 activation is a metabolic liability in lung cancer

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Ethical Issues in Genome Editing for Non-Human Organisms Using CRISPR/ Cas9 System

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Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells

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Evolutionary decay and the prospects for long-term disease intervention using engineered insect vectors: Figure 1.

Bull, J. J. (2015) · Evolution Medicine and Public Health · doi:10.1093/emph/eov013 · Cited by 20

Targeted genome engineering in Caenorhabditis elegans

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Dual-use nano-neurotechnology

Nixdorff, K., Borisova, Т., Комісаренко, С. В., & Dando, M. (2018) · Politics and the Life Sciences · doi:10.1017/pls.2018.15 · Cited by 20

Application of CRISPR/Cas Genomic Editing Tools for HIV Therapy: Toward Precise Modifications and Multilevel Protection

Maslennikova, A., & Mazurov, D. V. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.880030 · Cited by 22

Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity

Kleczko, E. K., Hinz, T. K., Nguyen, T. T., Gurule, N. J., Navarro, A., Le, A. T., Johnson, A. M., Kwak, J., Polhac, D. I., Clambey, E. T., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00355-2 · Cited by 20

CRISPR-Cas9-mediated genome editing delivered by a single AAV9 vector inhibits HSV-1 reactivation in a latent rabbit keratitis model

Amrani, N., Luk, K., Singh, P., Shipley, M. A., Isik, M., Donadoni, M., Bellizzi, A., Khalili, K., Sariyer, I. K., Neumann, D. M., et al. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101303 · Cited by 20

Modelling Epithelial Ovarian Cancer in Mice: Classical and Emerging Approaches

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Emerging Technologies to Create Inducible and Genetically Defined Porcine Cancer Models

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CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes

Huang, H., & Wu, Q. (2016) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.03.006 · Cited by 19

Application of CRISPR-mediated genome engineering in cancer research

Sayin, V. I., & Papagiannakopoulos, T. Y. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.029 · Cited by 20

Double Selection Enhances the Efficiency of Target-AID and Cas9-Based Genome Editing in Yeast

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CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets

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Induction of pancreatic neoplasia in the KRAS / TP53 Oncopig

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Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models

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Modeling Cancer in the CRISPR Era

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Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cellsPreprint

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CRISPR-Cas Systems in Precision Oncology: Current Applications and Future Challenges

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Drug Discovery Oncology in a Mouse: concepts, Models and Limitations

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Application of CRISPR screen in mechanistic studies of tumor development, tumor drug resistance, and tumor immunotherapy

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Efficient and multiplexed somatic genome editing with Cas12a mice

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The CRISPR revolution and its impact on cancer research

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CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions

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多样化CRISPR技术在动物体内基因编辑研究中的应用和进展

马迅, Ma, X., 黄芯渝, 谭晞彦, 崔雍建, 钟礼瞬, 冯波, Wong, A. S.-Y., Tam, H.-Y., Tsui, S. Y.-K., et al. (2018) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2017.012 · Cited by 17

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation

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Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

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In vivoandin vitrodisease modeling with CRISPR/Cas9

Kato, T., & Takada, S. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw031 · Cited by 16

Magnetic‐Activated Nanosystem with Liver‐Specific CRISPR Nonviral Vector to Achieve Spatiotemporal Liver Genome Editing as Hepatitis B Therapeutics

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Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools

Hasanzadeh, A., Ebadati, A., Dastanpour, L., Aref, A. R., Zangabad, P. S., Kalbasi, A., Dai, X., Mehta, G., Ghasemi, A., Fatahi, Y., et al. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00102 · Cited by 16

Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA

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CRISPR /Cas gene editing and delivery systems for cancer therapy

Li, Y., Zhou, S., Wu, Q., & Gong, C. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1938 · Cited by 16

Developmental history and application of CRISPR in human disease

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Functional Comparison between VP64-dCas9-VP64 and dCas9-VP192 CRISPR Activators in Human Embryonic Kidney Cells

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Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

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Speciation and adaptation research meets genome editing

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Adenoviral vectors transduce alveolar macrophages in lung cancer models

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Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components

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Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers

Cheong, T.-C., Jang, A., Wang, Q., Leonardi, G. C., Ricciuti, B., Alessi, J. V., Federico, A. D., Awad, M. M., Lehtinen, M. K., Harris, M. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49499-0 · Cited by 16

Genome Editing in Human Cells Using CRISPR/Cas Nucleases

Wyvekens, N., Tsai, S. Q., & Joung, J. K. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb3103s112 · Cited by 15

Applications of the CRISPR/Cas9 system in murine cancer modeling

Zuckermann, M., Kawauchi, D., & Gronych, J. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw021 · Cited by 15

Gene editing as a promising approach for respiratory diseases

Bai, Y., Liu, Y., Su, Z., Ma, Y., Ren, C., Zhao, R., & Ji, H. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2017-104960 · Cited by 15

Autochthonous murine models for the study of smoker and never-smoker associated lung cancers

Akbay, E. A., & Kim, J. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.06.04 · Cited by 16

Myostatin site‐directed mutation and simultaneous PPARγ site‐directed knockin in bovine genome

Ge, L., Kang, J., Dong, X., Luan, D., Su, G., Li, G., Zhang, Y., & Quan, F. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30017 · Cited by 15

CRISPR-Cas deployment in non-small cell lung cancer for target screening, validations, and discoveries

Sreedurgalakshmi, K., Srikar, R., & Rajkumari, R. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-00256-7 · Cited by 16

Erratic journey of CRISPR/Cas9 in oncology from bench-work to successful-clinical therapy

Sarkar, E., & Khan, A. A. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2020.100289 · Cited by 15

CRISPR-engineered genome editing for the next generation neurological disease modeling

Feng, W., Liu, H., & Kawauchi, D. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.019 · Cited by 15

Engineering stimuli-responsive nanocarriers for CRISPR/Cas9 genome editing: next-generation cancer therapeutics

Mehnath, S. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf127 · Cited by 14

The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice

Chen, M., Xu, E. S., Leisenring, N. H., Cardona, D. M., Luo, L., Ma, Y., Ventura, A., & Kirsch, D. G. (2019) · Sarcoma · doi:10.1155/2019/1340261 · Cited by 14

Toward precise CRISPR DNA fragment editing and predictable 3D genome engineering

Wu, Q., & Shou, J. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa060 · Cited by 15

Genome-editing approaches and applications: a brief review on CRISPR technology and its role in cancer

Siva, N., Gupta, S., Gupta, A., Shukla, J. N., Malik, B., & Shukla, N. (2021) · 3 Biotech · doi:10.1007/s13205-021-02680-4 · Cited by 14

Astonishing advances in mouse genetic tools for biomedical research

Jackson, W. S., & Kaczmarczyk, L. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14186 · Cited by 15

Targeting Cancer with Epi-Drugs: A Precision Medicine Perspective

Gherardini, L. M., Sharma, A., Capobianco, E., & Cinti, C. (2016) · Current Pharmaceutical Biotechnology · doi:10.2174/1381612822666160527154757 · Cited by 14

Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice

Zhu, W., Saw, D., Weiss, M., Sun, Z., Wei, M., Shaligram, S. S., Wang, S., & Su, H. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0676-1 · Cited by 14

Functional Genomics for Cancer Research: Applications In Vivo and In Vitro

O’Loughlin, T. A., & Gilbert, L. A. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055742 · Cited by 14

Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

Ragusa, D., Cicirò, Y., Federico, C., Saccone, S., Bruno, F., Saeedi, R., Sisu, C., Pina, C., Sala, A., & Tosi, S. (2022) · Oncogenesis · doi:10.1038/s41389-022-00426-2 · Cited by 15

Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome

Diaz-Jimenez, A., Ramos, M., Helm, B., Chocarro, S., Frey, D. L., Agrawal, S., Somogyi, K., Klingmüller, U., Lu, J., & Sotillo, R. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101081 · Cited by 14

Modeling cancer processes with CRISPR-Cas9

Lu, X., Qi, X., Zheng, D., & Ji, L.-J. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.03.007 · Cited by 13

The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo

Cheong, T.-C., Blasco, R. B., & Chiarle, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0593-1_4 · Cited by 13

Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

Kim, H., & Schaniel, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02243 · Cited by 14

Modeling Non-Alcoholic Fatty Liver Disease (NAFLD) Using “Good-Fit” Genome-Editing Tools

Kim, U., Kim, N., & Shin, H. Y. (2020) · Cells · doi:10.3390/cells9122572 · Cited by 13

Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes

Takadera, M., Satomi, K., Szulzewsky, F., Cimino, P. J., Holland, E. C., Yamamoto, T., Ichimura, K., & Ozawa, T. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01080-8 · Cited by 13

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

Polaski, J. T., Udy, D. B., Escobar‐Hoyos, L. F., Askan, G., Leach, S. D., Ventura, A., Kannan, R., & Bradley, R. K. (2021) · eLife · doi:10.7554/elife.62209 · Cited by 13

CRISPER/CAS System, a Novel Tool of Targeted Therapy of Drug-resistant Lung Cancer

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Parp3 promotes long-range end joining in murine cells

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