A targeted treatment with off-target risks
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Off-target effects limit the use of genome editing tools, as gene transfer between engineered bacteria and gut microbiota cannot be artificially controlled.
“Off-target effects limit the use of genome editing tools, as gene transfer between engineered bacteria and gut microbiota cannot be artificially controlled.17”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [17]
The citation lists haven’t been fetched yet
References 13 · Cited by 22
- Authors
- Fruman, D. A., & O'Brien, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Fruman, David A.
- ORCID
- O'Brien, Susan
- Venue
- Nature
- Published
- 2017-02
- Volume
- 542
- Issue
- 7642
- Pages
- 424-425
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2587923427
- Cited by
- 22
- References
- 13
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- PI3Kδ inhibitor, activation-induced cytidine deaminase, off-target effects, genomic instability, chronic lymphocytic leukemia, B-cell malignancies, DNA recombination, targeted cancer therapy
- MeSH terms
- Humans, Neoplasms, Risk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
