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Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway

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circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTOR Signaling

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Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1

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OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression

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Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation

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Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability

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mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation

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Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation

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tRNA‐Derived Fragment tRF‐5009A Regulates Autophagy and Degeneration of Cartilage in Osteoarthritis via Targeting mTOR

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EGOC inhibits TOROID polymerization by structurally activating TORC1

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Persistently Elevated mTOR Complex 1-S6 Kinase 1 Disrupts DARPP-32–Dependent D1 Dopamine Receptor Signaling and Behaviors

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Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif

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Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation

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Regulation of TORC2 Function and Localization in Yeast

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Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs

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Lysosomes as hubs of metabolic sensing and cellular homeostasis

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Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as an Important Scaffold for Anticancer Drug Discovery—In Vitro and In Silico Evaluation

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Mycobacterial SapM hampers host autophagy initiation for intracellular bacillary survival via dephosphorylating Raptor

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PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma

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Botanical Drug Puerarin Ameliorates Liposaccharide‐Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

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A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity

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Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth

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Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation

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Circadian Control of Protein Synthesis

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Translational Aspects of the Mammalian Target of Rapamycin Complexes in Diabetic Nephropathy

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Silencing RIPK1/mTORC1 signalling attenuated the inflammation and oxidative stress in diabetic cardiomyopathy

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Ras functional proximity proteomics establishes mTORC2 as new direct ras effector

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Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

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TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

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Structural Insights into the Activation of mTORC1 on the Lysosomal Surface

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Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs

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Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)

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G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation

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Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in Lymphocytes in Health and Disease

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LARP1 is a major phosphorylation substrate of mTORC1Preprint

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Structure of the human SAGA coactivator complex: The divergent architecture of human SAGA allows modular coordination of transcription activation and co-transcriptional splicingPreprint

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Convergence of signaling pathways in mediating actions of leucine and IGF-1 on mTORC1 in L6 myoblasts

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mTORC1 signaling and diabetic kidney disease

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REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes

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mTOR Variants Activation Discovers PI3K-like Cryptic Pocket, Expanding Allosteric, Mutant-Selective Inhibitor Designs

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Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS

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Multi-target renal protection in AKI: Exercise-mediated coordination of AMPK energy homeostasis, mTOR autophagy regulation, and NF-κB inflammatory control

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Quantitative Phosphoproteomics Reveals System-Wide Phosphorylation Network Altered by Spry in Mouse Mammary Stromal Fibroblasts

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Defective Cystinosin, Aberrant Autophagy−Endolysosome Pathways, and Storage Disease: Towards Assembling the Puzzle

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The skeletal muscle fiber periphery: A nexus of mTOR-related anabolism

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L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced Cell Migration through mTORC2 Activation at the Lysosome

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Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis

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Impact of initial postweaning feed intake on weanling piglet metabolism, gut health, and immunity

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The involvement of major signaling pathways in metastasis of colorectal cancer and the therapeutic application of their inhibitors

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Regulating T Cell Population Alleviates SLE by Inhibiting mTORC1/C2 in MRL/lpr Mice

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Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides

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Role of Autophagy in Myocardial Remodeling After Myocardial Infarction

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TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling

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Determination of mTORC1 Complex Structures Reveals Regulatory Mechanisms

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Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling

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Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates

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mTOR kinase structure, mechanism and regulation

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Abstract SY29-02: The TSC-mTOR pathway and control of anabolic tumor cell metabolism

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