The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genome sequence of the recombinant protein production host Pichia pastoris
Open accessAbstract
Pichia pastoris has been a workhorse of protein production for decades. De Schutter et al. present its genomic sequence, which will allow development of improved strains. The methylotrophic yeast Pichia pastoris is widely used for the production of proteins and as a model organism for studying peroxisomal biogenesis and methanol assimilation. P. pastoris strains capable of human-type N-glycosylation are now available, which increases the utility of this organism for biopharmaceutical production. Despite its biotechnological importance, relatively few genetic tools or engineered strains have been generated for P. pastoris. To facilitate progress in these areas, we present the 9.43 Mbp genomic sequence of the GS115 strain of P. pastoris. We also provide manually curated annotation for its 5,313 protein-coding genes.
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Cites
Stanke, M., Schöffmann, O., Morgenstern, B., & Waack, S. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-62 · Cited by 1,304
Assessing the gene space in draft genomes
Parra, G., Bradnam, K., Ning, Z., Keane, T., & Korf, I. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn916 · Cited by 395 · cited 1×
“According to recently proposed measures for genome completeness, we searched the genome for highly conserved single (or low) copy gene sets: core eukaryotic genes (CEGs) with 248 genes across six model organism”
Nonrandom utilization of codon pairs in Escherichia coli.
Gutman, G. A., & Hatfield, G. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3699 · Cited by 261 · cited 1×
“Some synonymous codon pairs are also more or less frequently used than expected (the codon pair bias”
Cited by
Phylogenetic reconstruction based on synteny block and gene adjacencies
Drillon, G., Champeimont, R., Oteri, F., Fischer, G., & Carbone, A. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa114 · Cited by 46
Metadata
- Authors
- De Schutter, K., Lin, Y.-C., Tiels, P., Van Hecke, A., Glinka, S., Weber-Lehmann, J., Rouzé, P., Van de Peer, Y., & Callewaert, N.
- Venue
- Nature Biotechnology
- Published
- 2009-05-24
- Volume
- 27
- Issue
- 6
- Pages
- 561-566
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2098693002
- Cited by
- 537
- References
- 3
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- De Schutter, K., Lin, Y.-C., Tiels, P., Van Hecke, A., Glinka, S., Weber-Lehmann, J., Rouzé, P., Van de Peer, Y., & Callewaert, N. (2009). Genome sequence of the recombinant protein production host Pichia pastoris. Nature Biotechnology. https://doi.org/10.1038/nbt.1544
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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