Influence of donor age on induced pluripotent stem cells

Lo Sardo, Valentina, Ferguson, William, Erikson, Galina A, Topol, Eric J, Baldwin, Kristin K, Torkamani, Ali·2017·Nature Biotechnology

Cited by (224)

Items 101–200 of 224

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  3. Implications of Cellular Aging in Cardiac Reprogramming
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  5. Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
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  6. Role of induced pluripotent stem cells in lysosomal storage diseases
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  7. Umbilical Cord Tissue as a Source of Young Cells for the Derivation of Induced Pluripotent Stem Cells Using Non-Integrating Episomal Vectors and Feeder-Free Conditions
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  8. KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation
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  9. Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability
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  10. Current Technologies Based on the Knowledge of the Stem Cells Microenvironments
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  11. The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs
    Flavia Palombo, Camille Peron, Leonardo Caporali, Angelo Iannielli, Alessandra Maresca, Ivano Di Meo, Claudio Fiorini, Alice Segnali, Francesca L. Sciacca, Ambra Rizzo et al. · 2021 · Stem Cell Reports
  12. Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia
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  13. The 9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State
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  14. Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts
    Narisu Narisu, Rebecca Rothwell, Peter Vrtačnik, Sofía Rodríguez, John P. Didion, Sebastian K. Zöllner, Michael R. Erdos, Francis S. Collins, Maria Eriksson · 2019 · Aging Cell
  15. Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research
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  16. Discerning combining ability loci for divergent environments using chromosome segment substitution lines (CSSLs) in pearl millet
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  17. Targeting α-Synuclein in Parkinson's Disease by Induced Pluripotent Stem Cell Models
    Angeliki Spathopoulou, Frank Edenhofer, Lisa Fellner · 2022 · Frontiers in Neurology
  18. Direct Cell Reprogramming and Phenotypic Conversion: An Analysis of Experimental Attempts to Transform Astrocytes into Neurons in Adult Animals
    Rachel Dennison, Esteban Usuga, Harriet Chen, Jacob Z. Paul, Christian A. Arbelaez, Yang Dong Teng · 2023 · Cells
  19. Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts
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  20. Generation of iPSC lines with high cytogenetic stability from peripheral blood mononuclear cells (PBMCs)
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  21. MECHANISMS IN ENDOCRINOLOGY: Towards the clinical translation of stem cell therapy for type 1 diabetes.
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  22. Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases
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  23. “Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
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  24. Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease
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  25. The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients
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  26. Aberrant neuronal connectivity and network activity of neurons derived from patients with idiopathic schizophrenia
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  28. The Role of Human-Induced Pluripotent Stem Cells in Studying Cardiac Channelopathies
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  30. Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy
    Stephanie M. Matt · 2021 · Brain Behavior & Immunity - Health
  31. TET2 Haploinsufficiency Alters Reprogramming into Induced Pluripotent Stem Cells
    Lise Secardin, Cintia Elisabeth Gomez Limia, Antonio Di Stefano, Martín Bonamino, Joseph Saliba, Keisuke Kataoka, Stevens Kastrup Rehen, Hana Raslová, Caroline Marty, Seishi Ogawa et al. · 2020 · Stem Cell Research
  32. Regenerative Medicine Perspectives in Polycystic Ovary Syndrome
    Babak Arjmand, Setareh Alaei, Najmeh Foroughi Heravani, Sepideh Alavi-Moghadam, Moloud Payab, Mahbube Ebrahimpour, Hamid Reza Aghayan, Parisa Goodarzi, Bagher A. Larijani · 2021 · Advances in experimental medicine and biology
  33. Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging
    Jean Philippe Trani, Raphaël Chevalier, Leslie Caron, Claire El Yazidi, Natacha Broucqsault, Léa Toury, Morgane Thomas, Karima Annab, Bernard Binétruy, Annachiara De Sandre‐Giovannoli et al. · 2022 · Life Science Alliance
  34. Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids
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  35. Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development
    Alessandro Donada, Francesca Basso‐Valentina, Brahim Arkoun, Bárbara da Costa Reis Monte-Mór, Isabelle Plo, Hana Raslová · 2020 · Stem Cell Research
  36. Reliable multiplex generation of pooled induced pluripotent stem cells
    Molly Smullen, Meagan N. Olson, Julia M. Reichert, Pepper Dawes, Liam F. Murray, Christina E. Baer, Qi Wang, Benjamin P. Readhead, George McDonald Church, Elaine T. Lim et al. · 2023 · Cell Reports Methods
  37. SG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort
    Manuel Rueda, Ali Torkamani · 2017 · BMC Bioinformatics
  38. Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain
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  39. Retinal Ganglion Cells in a Dish: Current Strategies and Recommended Best Practices for Effective In Vitro Modeling of Development and Disease
    Kang-Chieh Huang, Cátia Gomes, Jason S. Meyer · 2023 · Handbook of experimental pharmacology
  40. From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review)
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  41. Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation
    Yu-Che Cheng, Chi-Jung Huang, Wei‐Chi Ku, Shu-Lin Guo, Lu-Tai Tien, Yih-Jing Lee, Chih-Cheng Chien · 2022 · Stem Cell Reviews and Reports
  42. Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells
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  44. A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study
    Rhea E. Sullivan, Quinn Ahrens, Sara L. Mills-Huffnagle, Irina A. Elcheva, Steven D. Hicks · 2025 · PLoS ONE
  45. Application of Induced Pluripotent Stem Cell-Derived Models for Investigating microRNA Regulation in Developmental Processes
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  46. Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny
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  47. Reprogramming of adult human dermal fibroblasts to induced dorsal forebrain precursor cells maintains aging signatures
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  48. Stem Cell–Derived Islet Transplantation in Patients With Type 2 Diabetes: Can Diabetes Subtypes Guide Implementation?
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  51. The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies
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  52. Update on Mesenchymal and Induced Pluripotent Stem Cells
    Khalid Ahmed Al‐Anazi · 2019 · IntechOpen eBooks
  53. Emerging strategies in corneal Regeneration: The role of induced pluripotent stem cell-based therapies
    Hao Zhang, Jorge L. Alió del Barrio, Maria Paz De Miguel, Jorge L. Alió · 2025 · Experimental Eye Research
  54. Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion
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  56. Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease
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  57. Heterogeneity and optimal study design between cell lines in induced pluripotent stem cell-based cardiac disease modeling
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  58. In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems
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  59. The therapeutic effects of induced pluripotent stem cell‐derived mesenchymal stem cells on Parkinson's disease
    Ren Hao, Yuwei Wang, Yingying Chen, Feilong Ma, Qing Shi, Zichen Wang, Yaoting Gui, Jianbo Liu, Huiru Tang · 2024 · IUBMB Life
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