The DOI matches its Crossref record.
New therapies from old medicines
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IND submissions are often misused by opportunistic manufacturers to claim scientific credentials for already-marketed dietary supplements, exploiting laypersons' inability to distinguish between INDs and approved drugs.
“IND submissions are often misused by opportunistic manufacturers to claim scientific credentials for already-marketed dietary supplements, exploiting laypersons' inability to distinguish between INDs and approved drugs.”
From Indian Imaginaries of Chinese Success in the Global Herbal Medicine Market: A Critical Assessment (2019) · cites this paper as S. Chen et al. 2008, 1080
In “From dietary supplements to new drugs” (p. 1077), the paper distinguishes dietary supplements from drugs; its discussion of IND submissions addresses regulatory review and prior human experience. The passages on supplement claims say those claims can be confusing, but do not say manufacturers misuse IND submissions to confer scientific credibility or that consumers confuse INDs with approved drugs. Searches for IND misuse, marketing of supplements, and promotion of IND status found no passage addressing that allegation. (LLM, conf=0.77)
Experimental — accuracy not yet measuredTrials are often terminated midway because unfavorable results could jeopardize their current market.
“Trials are often terminated midway, because unfavorable results could jeopardize their current market.”
From Indian Imaginaries of Chinese Success in the Global Herbal Medicine Market: A Critical Assessment (2019) · cites this paper as S. Chen et al. 2008, 1080
The discussion of dietary supplements and clinical testing (p. 1077) says that reporting clinical testing to the FDA is not required for certain marketed products. It does not say that trials are often terminated midway to protect an existing market. Searches for premature trial termination, unfavorable results, and commercial concerns found no passage addressing that claim. (LLM, conf=0.73)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 13
- Wu, K.M. et al. Toxicol. Lett. 111, 199–202 (2000). · DOI
- Wu, K.M. et al. Am. J. Ther. 11, 213–217 (2004). · DOI
- Murayama, M., Takao, M., Bando, H. & Amiya, T. J. Ethnopharmacol. 35, 159–164 (1991). · DOI
- Lindenmuth, G.F. & Lindenmuth, E.B. J. Altern. Complement. Med. 6, 327–334 (2000). · DOI
- Turner, R.B., Bauer, R., Woelkart, K., Hulsey, T.C. & Gangemi, J.D. N. Engl. J. Med. 353, 341–348 (2005). · DOI
- Hypericum Depression Trial Study Group. J. Am. Med. Assoc. 287, 1807–1814 (2002). · DOI
- Shelton, R.C. et al. J. Am. Med. Assoc. 285, 1978–1986 (2001). · DOI
- Kasper, S., Anghelescu, I.G., Szegedi, A., Dienel, A. & Kieser, M. BMC Med. 4, 14 (2006). · DOI
- Nakachi, K., Eguchi, H. & Imai, K. Ageing Res. Rev. 2, 1–10 (2003). · DOI
- Lin, Y.S., Tsai, Y.J., Tsay, J.S. & Lin, J.K. J. Agric. Food Chem. 51, 1864–1873 (2003). · DOI
- Jiang, X. New Medical College, Encyclopedia of Chinese Materia Medica (Zhong Yao Da Ci Dian) (Shanghai People's Press, Shanghai, China, 1977).
- Stevens, T., Qadri, A. & Zein, N.N. Ann. Intern. Med. 142, 477–478 (2005). · DOI
- Gloro, R. et al. Eur. J. Gastroenterol. Hepatol. 17, 1135–1137 (2005). · DOI
Cited by
Sorted by citations
Indian Imaginaries of Chinese Success in the Global Herbal Medicine Market: A Critical Assessment
Kudlu, C., & Nichter, M. (2019) · Asian Medicine · doi:10.1163/15734218-12341437 · Cited by 7
Metadata
- Authors
- Chen, S. T., Dou, J., Temple, R., Agarwal, R., Wu, K.-M., & Walker, S.
- Affiliations
- United States Food and Drug Administration (US)
- Venue
- Nature Biotechnology
- Published
- 2008-10
- Volume
- 26
- Issue
- 10
- Pages
- 1077-1083
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2061285450
- Cited by
- 101
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 11 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 13
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- public-domain
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- plant-derived drugs, herbal medicine, drug approval, FDA regulation, new drug development, prescription drugs
- MeSH terms
- Drug Industry, Phytotherapy, Plant Extracts, United States, United States Food and Drug Administration, Drug Approval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
