Clusterin inhibits apoptosis by interacting with activated Bax

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

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Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells

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Posttranscription Regulation of Prostate Cancer Growth

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The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft

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Glycosylated clusterin species facilitate Aβ toxicity in human neurons

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Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?

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B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: Implications for cell survival

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Mouse Mammary Tumor Virus Suppresses Apoptosis of Mammary Epithelial Cells through ITAM-Mediated Signaling

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Research in Castration-Resistant Rostate Cancer: What Does the Future Hold?

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Genistein Modulation of Immune-Associated Genes in LNCaP Prostate Cancer Cell Line

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19q13-ERCC1 Gene Copy Number Increase in Non–Small-Cell Lung Cancer

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Plasma levels of Clusterin are representative of the early phase of the neurodegenerative process in Parkinson’s disease

Polimeno, L., Asabella, A. N., Mazzocca, A., Fazio, G. D., Polimeno, R., Buquicchio, R., Lavelli, V., & Rubini, G. (2018) · Journal of Clinical and Molecular Medicine · doi:10.15761/jcmm.1000102 · Cited by 11

Review of proteomics approach to eye diseases affecting the anterior segment

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Role of the lncRNA–mRNA network in atherosclerosis using ox-low-density lipoprotein-induced macrophage-derived foam cells

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Cotransin induces accumulation of a cytotoxic clusterin variant that cotranslationally rerouted to the cytosol

Choi, I., Kim, J., Park, J., & Kang, S. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.01.025 · Cited by 11

Addressing Taxane Resistance in Metastatic Castration-Resistant Prostate Cancer: A Focus On Chaperone Proteins

Hotte, S. J. (2016) · Future Oncology · doi:10.2217/fon-2016-0279 · Cited by 11

Changes of Transthyretin and Clusterin after Androgen Ablation Therapy and Correlation with Prostate Cancer Malignancy

Wang, D., Liang, H., Mao, X., Liu, W., Li, M., & Qiu, S. (2012) · Translational Oncology · doi:10.1593/tlo.11259 · Cited by 11

Oligomeric amyloid beta prevents myelination in a clusterin-dependent mannerPreprint

Beiter, R. M., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Phillips, J. L., Bathe, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.06.981373 · Cited by 11

Decoding CLU (Clusterin): Conquering cancer treatment resistance and immunological barriers

Mamun, M., Zheng, Y., Wang, N., Wang, B., Zhang, Y. X., Pang, J., Shen, D., Liu, H., & Gao, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112355 · Cited by 10

Novel Targeted Therapies for Prostate Cancer

Macfarlane, R. J., & Chi, K. N. (2010) · Urologic Clinics of North America · doi:10.1016/j.ucl.2009.11.011 · Cited by 10

Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected with Trichinella spiralis, Trichinella britovi, and Trichinella pseudospiralis

Gondek, M., Herosimczyk, A., Knysz, P., Ozgo, M., Lepczyński, A., & Szkucik, K. (2020) · Pathogens · doi:10.3390/pathogens9010055 · Cited by 10

Molecular delineation, expression profiling, immune response, and anti-apoptotic function of a novel clusterin homolog from big-belly seahorse (Hippocampus abdominalis)

Wijerathna, H. M. S. M., Nadarajapillai, K., Udayantha, H. M. V., Kasthuriarachchi, T. D. W., Shanaka, K. A. S. N., Kwon, H., Wan, Q., & Lee, J. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.04.015 · Cited by 10

Secretion and Immunogenicity of the Meningioma-Associated Antigen TXNDC16

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Differential expression of genes characterizing myofibre phenotype

Nierobisz, L. S., Sporer, K. R. B., Strasburg, G. M., Reed, K. M., Velleman, S. G., Ashwell, C. M., Felts, J. V., & Mozdziak, P. E. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2011.02249.x · Cited by 10

Response of Bladder Carcinoma Cells to TRAIL and Antisense Oligonucleotide, Bcl-2 or Clusterin Treatments

Sun, B., Moibi, J. A., Mak, A., Xiao, Z. J., Roa, W., & Moore, R. B. (2009) · The Journal of Urology · doi:10.1016/j.juro.2008.10.148 · Cited by 10

NF-κB-dependent genes induced by proteinuria and identified using DNA microarrays

Takase, O., Marumo, T., Hishikawa, K., Fujita, T., Quigg, R. J., & Hayashi, M. (2008) · Clinical and Experimental Nephrology · doi:10.1007/s10157-008-0038-5 · Cited by 10

Secretory Clusterin as a Novel Molecular-targeted Therapy for Inhibiting Hepatocellular Carcinoma Growth

Yao, M., Sai, W., Zheng, W., Wang, L., Dong, Z., & Yao, D. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190624161158 · Cited by 10

Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients

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Clusterin/Apolipoprotein J immunolocalization on carotid artery is affected by TNF-alpha, cigarette smoking and anti-platelet treatment

Yanni, A. E., Agrogiannis, G. D., Gkekas, C., & Perrea, D. N. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-70 · Cited by 10

Therapeutic Potential of Clusterin Inhibition in Human Cancer

Martín‐García, D., García‐Aranda, M., & Redondo, M. (2024) · Cells · doi:10.3390/cells13080665 · Cited by 9

Glyceryl trinitrate‑induced cytotoxicity of docetaxel‑resistant prostatic cancer cells is associated with differential regulation of clusterin

Bouaouiche, S., Magadoux, L., Dondaine, L., Reveneau, S., Isambert, N., Bettaı̈eb, A., Jeannin, J., Laurens, V., & Plenchette, S. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4708 · Cited by 9

Cytoplasmic Clusterin Suppresses Lung Cancer Metastasis by Inhibiting the ROCK1-ERK Axis

Huang, S., Li, X., Gu, W., Li, X., Zhao, J., Wu, J., Cai, J., Feng, X., & Tao, T. (2022) · Cancers · doi:10.3390/cancers14102463 · Cited by 9

Se-Methylselenocysteine Inhibits Apoptosis Induced by Clusterin Knockdown in Neuroblastoma N2a and SH-SY5Y Cell Lines

Wang, C., Zeng, Z., Liu, Q., Zhang, R., & Ni, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121331 · Cited by 9

Brain and plasmatic CLUSTERIN are translational markers of Alzheimer's disease

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Proteome Profiling of Canine Epididymal Fluid: In Search of Protein Markers of Epididymal Sperm Motility

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Chapter 4 Regulation of Clusterin Activity by Calcium

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Flavored little cigar smoke induces cytotoxicity and apoptosis in airway epithelia

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Atorvastatin mediates increases in intralesional BAX and BAK expression in human end-stage abdominal aortic aneurysms

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Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells

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Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma

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[Hypomania/mania induced by cessation of antidepressant drugs].

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Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model

Wang, Y., Jia, Y., Yan, L., Fu, J., Hao, M., Chen, W. L., Yao, B., Zhao, P., & Zhou, Z. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.08.002 · Cited by 8

Octreotide induces apoptosis in the oxyntic mucosa

Erlandsen, S. E., Fykse, V., Waldum, H. L., & Sandvik, A. K. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.031 · Cited by 8

Emerging apoptosis agonists for bladder cancer

Protzel, C., & Hakenberg, O. W. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210903251708 · Cited by 7

Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma

Narahara, S., Watanabe, T., Nagaoka, K., Fujimoto, N., Furuta, Y., Tanaka, K., Tokunaga, T., Kawasaki, T., Yoshimaru, Y., Setoyama, H., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1872 · Cited by 7

Improved Drug-Response Prediction Model of APC Mutant Colon Cancer Patient-Derived Organoids for Precision Medicine

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From Humans to Experimental Models: The Cytoprotective Role of Clusterin in the Kidney

Alnasser, Q. G. H. A. (2014) · Medical & Surgical Urology · doi:10.4172/2168-9857.1000134 · Cited by 7

The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro

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CLU blocks HDACI-mediated killing of neuroblastoma

Subramanian, C., Jarzembowski, J. A., Halsey, S. M., Kuick, R. D., Opipari, A. W., Castle, V. P., & Kwok, R. P. S. (2010) · Tumor Biology · doi:10.1007/s13277-010-0120-y · Cited by 7

Tamoxifen Suppresses Clusterin Level through Akt Inactivation and Proteasome Degradation in Human Prostate Cancer Cells

Shim, J.-H., Choi, C.-S., Lee, E.-C., Kim, M.-Y., & Chun, Y. (2009) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2009.17.1.25 · Cited by 7

The Role of Genetics in Alzheimer's Disease and Parkinson's Disease

Porter, T., Gozt, A., Mastaglia, F. L., & Laws, S. M. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch15 · Cited by 6

Physiological Level of Eosinophils Is Essential for the Regeneration and Homeostasis of Murine Hematopoietic Stem Cells

Zhang, C., Yi, W., Shao, Z., Yao, B., Tian, G., Li, F., Du, X., Hu, Y., Guo, Y., Wu, T., et al. (2025) · Allergy · doi:10.1111/all.70021 · Cited by 6

In silico structural analysis of secretory clusterin to assess pathogenicity of mutations identified in the evolutionarily conserved regions

Das, L. N., Shekhar, S., Chandrani, P., & Varma, A. K. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.2007791 · Cited by 6

In vitro HIV DNA integration in STAT3 drives T cell persistence—A model of HIV-associated T cell lymphoma

Rist, M., Kaku, M., & Coffin, J. M. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013087 · Cited by 6

Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes

Hsu, W.-T., Kobuchi, S., Chien, T.-C. R., Chen, I., Hamada, S., Tsujimoto, M., Tsai, I., Wong, Y.-S., Tung, K.-H., & He, Y.-Z. (2025) · Biology Direct · doi:10.1186/s13062-025-00664-5 · Cited by 7

Clusterin and Its Isoforms in Oral Squamous Cell Carcinoma and Their Potential as Biomarkers: A Comprehensive Review

Zhang, Q., Teow, J. Y., Kerishnan, J. P., Halim, A. A. A., & Chen, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11051458 · Cited by 7

The C-terminus of interferon gamma receptor beta chain (IFNγR2) has antiapoptotic activity as a bax inhibitor

Gómez, J. A., Sun, W., Gama, V., Hájková, D., Yoshida, T., Wu, Z., Miyagi, M., Pink, J. J., Jackson, M. W., Danielpour, D., et al. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.18.9323 · Cited by 6

Clusterin (apolipoprotein J) facilitates NF-κB and Bax degradation and prevents I/R injury in heart transplantation.

Du, J., Liu, L., Yu, B., Hao, F., Liu, G., Jing, H., & Xu, H. (2018) · PubMed Central · Cited by 6

Transcriptional analysis of cleft palate in TGFβ3 mutant mice

Liu, J., Chanumolu, S. K., White, K. M., Albahrani, M., Otu, H. H., & Nawshad, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-71636-0 · Cited by 6

Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms

Rajasekaran, S., Tangavel, C., Raja, S. D. C., Raveendran, M., Nayagam, S. M., Anand, K. S. S. V., Prasad, S. A., & Mugesh, K. R. (2021) · European Spine Journal · doi:10.1007/s00586-021-06826-z · Cited by 6

Antisense therapies for cancer

MacLeod, A. R. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.04.002 · Cited by 6

Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan

Rostagno, A. A., Calero, M., Holton, J. L., Révész, T., Lashley, T., & Ghiso, J. A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105452 · Cited by 6

The NBPF Gene Family

Andries, V., Vandepoele, K., & van, F. (2012) · InTech eBooks · doi:10.5772/28470 · Cited by 6

Germ cell-specific apoptosis by extracellular clusterin in cryptorchid dog testes

Jhun, H., Park, H.-J., Lee, R., Song, H., Hur, T., Lee, S., Park, J.-K., & Lee, W.-Y. (2018) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2018.04.064 · Cited by 6

Clusterin is not essential for androgen-regulated involution and regeneration of the normal mouse prostate

Fink, D., Fazli, L., Aronow, B. J., Gleave, M. E., & Ong, C. J. (2006) · The Prostate · doi:10.1002/pros.20461 · Cited by 6

Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis

Inamdar, T. V., Krannich, F., Hesselbarth, N., Verma, A., Vauti, T., Jasaszwili, M., Kassem, G. E., Hillmer, J., Kaune, T., Boettcher, M., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335947 · Cited by 5

Novel Targeted Agents on the Horizon for Castration-Resistant Prostate Cancer

Koupparis, A. J., Casey, R. G., Robinson, M., & Gleave, M. E. (2010) · Future Oncology · doi:10.2217/fon.10.145 · Cited by 5

Clusterin is upregulated by erastin, a ferroptosis inducer and exerts cytoprotective effects in pancreatic adenocarcinoma cells

Li, Y., Wang, X., Chen, Y., Tan, Q., Liu, X.-B., & Tan, C. (2023) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001561 · Cited by 5

New targets and non-cytotoxics in ovarian cancer

Eisenhauer, E. A. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl268 · Cited by 5

Effect of Targeting Clusterin Using OGX-011 on Antitumor Activity of Temsirolimus in a Human Renal Cell Carcinoma Model

Nishikawa, M., Miyake, H., Gleave, M. E., & Fujisawa, M. (2016) · Targeted Oncology · doi:10.1007/s11523-016-0448-3 · Cited by 5

Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis

Iyer, S. V., Park, M.-J., Moons, D. S., Kwan, R., Liao, J., Liu, L., & Omary, M. B. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.039 · Cited by 5

Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects

Choi, J. H., Jeong, E., Youn, B. S., & Kim, M. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.2.245 · Cited by 5

Research on Analysis of Final Diagnosis and Prognostic Factors, and Development of New Therapeutic Drugs for Malignant Tumors (Especially Malignant Pediatric Tumors)

Suzuki, T. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00178 · Cited by 5

Molecular Chaperone Inhibitors

Moses, M. A., Zuehlke, A. D., & Neckers, L. (2018) · Springer eBooks · doi:10.1007/978-3-319-69042-1_2 · Cited by 5

Differential age‐associated regulation of clusterin expression in prostate lobes of brown norway rats

Omwancha, J., Anway, M. D., & Brown, T. R. (2008) · The Prostate · doi:10.1002/pros.20866 · Cited by 5

Molecular and Genetic Profiling of Prostate Cancer: Implications for Future Therapy

Saia, G., Zhang, M., Depalo, V., Lautenschlaeger, T., & Chakravarti, A. (2007) · Current Cancer Therapy Reviews · doi:10.2174/157339407780126647 · Cited by 5

Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

LaBarre, B. A., King, D., Ploumakis, A., Pinzon, A. M., Guttmann, C. R. G., Patsopoulos, N., & Chitnis, T. (2025) · BMC Medical Genomics · doi:10.1186/s12920-025-02294-2 · Cited by 4

Proteomic Insights into Seminal Plasma and Spermatozoa Proteins of Small-Spotted Catsharks, Scyliorhinus canicula: Implications for Reproductive Conservation in Aquariums

Muñoz-Baquero, M., Lorenzo-Rebenaque, L., García‐Domínguez, X., Valdés‐Hernández, J., García‐Párraga, D., Marín, C., García‐Vázquez, F. A., & Marco‐Jiménez, F. (2024) · Animals · doi:10.3390/ani14091281 · Cited by 4

Cellular Characterization and Interspecies Evolution of the Tree Shrew Retina across Postnatal Lifespan

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Clusterin can mediate apoptosis-induced molecular mechanisms in immune thrombocytopenia

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Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor

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Sciatic Nerve Ligation Downregulates Mitochondrial Clusterin in the Rat Prefrontal Cortex

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Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum

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Noncoding-RNA-Based Therapeutics with an Emphasis on Prostatic Carcinoma—Progress and Challenges

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Cell Biology of Prostate Cancer and Molecular Targets

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Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin

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Radicicol induces intracellular accumulation of glycan-deficient clusterin variant

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Meta-analysis of efficacy and safety of custirsen in patients with metastatic castration-resistant prostate cancer

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Clusterin levels in undernourished SH-SY5Y cells

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Transcriptomes of Clusterin- and S100B-transfected neuronal cells elucidate protective mechanisms against hypoxia and oxidative stress in the hooded seal (Cystophora cristata) brain

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In Silico Analysis Highlights Potential Predictive Indicators Associated with Secondary Progressive Multiple Sclerosis

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Analysis of the expression patterns of AVP, IGF-1, and TNF-α, APP, CD44, IFN-β IFN A β-6, α-syn, and NFL and CLU genes in generalized and focal seizures

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Genes Involved in the Cell Death Induced by Knockdown of Heat Shock Transcription Factor 1 in Human Oral Squamous Cell Carcinoma HSC-3 Cells

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The Tumor Suppressor von Hippel-Lindau Gene Product and Metastasis

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Clusterin overexpression as a potential neuroprotective response to the pathological effects of high fat dieting on the brain reward system

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Extracellular Chaperones

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Zinc-binding proteins in stallion seminal plasma as potential sperm function regulators

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Downregulation of CLU mediates CART-induced apoptosis and suppressed proliferation in bovine granulosa cells

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Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

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The anti-apoptotic protein clusterin is induced by cancer chemotherapy, stabilized by the proteasome, and degraded by intracellular proteases

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CLU blocks HDACI-mediated killing of neuroblastoma

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Resistance to cytotoxic chemotherapy-induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression

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Clusterin-Mediated Apoptosis Is Regulated by Adenomatous Polyposis Coli and Is p21 Dependent but p53 Independent

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