The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell fate decisions are specified by the dynamic ERK interactome
Open accessAbstract
Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying the switch could be revealed by assessing the dynamic changes in ERK-interacting proteins that specifically occur under differentiation conditions. Using quantitative proteomics, we identified 284 ERK-interacting proteins. Upon induction of differentiation, 60 proteins changed their binding to ERK, including many proteins that were not known to participate in differentiation. We functionally characterized a subset, showing that they regulate the pathway at several levels and by different mechanisms, including signal duration, ERK localization, feedback, crosstalk with the Akt pathway and differential interaction and phosphorylation of transcription factors. Integrating these data with a mathematical model confirmed that ERK dynamics and differentiation are regulated by distributed control mechanisms rather than by a single master switch.
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Ahmadian, M. R., Hoffmann, U., Goody, R. S., & Wittinghofer, A. (1997) · Biochemistry · doi:10.1021/bi962556y · Cited by 141
Unique MAP Kinase binding sites
Akella, R., Moon, T. M., & Goldsmith, E. J. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.09.016 · Cited by 108
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The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
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Metadata
- Authors
- von Kriegsheim, A., Baiocchi, D., Birtwistle, M., Sumpton, D., Bienvenut, W., Morrice, N., Yamada, K., Lamond, A., Kalna, G., Orton, R., Gilbert, D., & Kolch, W.
- Venue
- Nature Cell Biology
- Published
- 2009-11-22
- Volume
- 11
- Issue
- 12
- Pages
- 1458-1464
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2071141381
- Cited by
- 286
- References
- 2
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- von Kriegsheim, A., Baiocchi, D., Birtwistle, M., Sumpton, D., Bienvenut, W., Morrice, N., Yamada, K., Lamond, A., Kalna, G., Orton, R., Gilbert, D., & Kolch, W. (2009). Cell fate decisions are specified by the dynamic ERK interactome. Nature Cell Biology. https://doi.org/10.1038/ncb1994
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