MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
Open accessAbstract
The BH3-only BID protein (BH3-interacting domain death agonist) has a critical function in the death-receptor pathway in the liver by triggering mitochondrial outer membrane permeabilization (MOMP). Here we show that MTCH2/MIMP (mitochondrial carrier homologue 2/Met-induced mitochondrial protein), a novel truncated BID (tBID)-interacting protein, is a surface-exposed outer mitochondrial membrane protein that facilitates the recruitment of tBID to mitochondria. Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of tBID to mitochondria, the activation of Bax/Bak, MOMP, and apoptosis. Moreover, conditional knockout of MTCH2/MIMP in the liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria both in vivo and in vitro. In contrast, MTCH2/MIMP deletion had no effect on apoptosis induced by other pro-apoptotic Bcl-2 family members and no detectable effect on the outer membrane lipid composition. These loss-of-function models indicate that MTCH2/MIMP has a critical function in liver apoptosis by regulating the recruitment of tBID to mitochondria.
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Translocation of tBID to OMM, at least upon FAS stimulation, reportedly depends on binding of MOAP1 to MTCH2.
“via a mechanism that, at least upon FAS stimulation, reportedly depends on the binding of modulator of apoptosis 1 (MOAP1) to the alleged BID receptor mitochondrial carrier 2 (MTCH2) [315, 316].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [316]
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References 40 · Cited by 218
Research works printed but not linked: 1
- [27]Hogan B Beddington R Constantini F Lacy E Manipulating the Mouse Embryo 1994 Cold Spring Harbor Laboratory Press
- Authors
- Zaltsman, Y., Shachnai, L., Yivgi-Ohana, N., Schwarz, M., Maryanovich, M., Houtkooper, R. H., Vaz, F. M., De Leonardis, F., Fiermonte, G., Palmieri, F., Gillissen, B., Daniel, P. T., Jimenez, E., Walsh, S., Koehler, C. M., Roy, S. S., Walter, L., Hajnóczky, G., & Gross, A.
- Affiliations
- Weizmann Institute of Science (IL)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Amsterdam (NL)
- University of Bari Aldo Moro (IT)
- Humboldt-Universität zu Berlin (DE)
- University of California, Los Angeles (US)
- Thomas Jefferson University (US)
- Corresponding author
- Gross, Atan
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2010-05-02
- Volume
- 12
- Issue
- 6
- Pages
- 553-562
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4070879
- OpenAlex
- W2012324453
- Cited by
- 218
- References
- 40
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 12 · 2023: 10 · 2022: 7 · 2021: 14 · 2020: 9 · 2019: 2 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 14 · 2014: 10 · 2013: 22 · 2012: 23
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM059419, R01GM061721)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- tBid, mitochondrial outer membrane permeabilization, BH3-only proteins, Fas-mediated apoptosis, hepatocyte apoptosis, death receptor signaling, mitochondrial outer membrane proteins, Bcl-2 family proteins
- MeSH terms
- Animals, Fibroblasts, Mitochondria, Mitochondria, Liver, Apoptosis, Mice, Knockout, Mitochondrial Proteins, Membrane Transport Proteins, Mitochondrial Membrane Transport Proteins, BH3 Interacting Domain Death Agonist Protein, Mitochondrial Membranes, Mice, Receptors, Death Domain
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